Results 71 to 80 of about 226,399 (222)

Transfer of paracetamol across the placenta and fetal blood–brain barriers and its safety for use in pregnancy

The Journal of Physiology, EarlyView.
Abstract figure legend Paracetamol (acetaminophen) is commonly taken during pregnancy for pain and fever. To gain a more comprehensive understanding of paracetamol's effects during pregnancy, several elements need to be examined including the transfer of paracetamol across the placenta and into the developing brain, the short‐ and long‐term effects of ...
Yifan Huang, Liam Koehn
wiley   +1 more source

Comparing the Effect of Microinjection of Angiotensin II and Captopril to the Locus Coeruleus on Morphine Withdrawal Signs in Rat

مجله دانشکده پزشکی اصفهان, 2009
Background: Locus coeruleus is one of important involved sites in morphine withdrawal signs, contains high densities of Angiotensin II receptor binding sites.
Zohreh Azizolahi, Hojatollah Alaei, Mahmoud Hosseini, Ali Asghar Pilehvarian   +3 more
doaj  

Integrated Phytochemical Characterisation, Pharmacological Evaluation and Computational Investigation of Acampe papillosa Stem Extract

Analytical Science Advances, Volume 7, Issue 2, December 2026.
The pharmacological potential of the methanolic stem extract of Acampe papillosa is evaluated using in vivo and in silico approaches. The extract demonstrates significant anxiolytic, sedative, anti‐inflammatory, and antipyretic activities in experimental models, while molecular docking supports the observed biological effects through favorable ...
Qurratul Ain Sadia, Sadia Tamanna Tamim, Faruq Mohammed Tashriq, Nasir Uddin, Fatematus Zhohara Alam Hima, Ulfat Sobha Surat, Mily Khastagir, Muhammad Abdul Jalil, Md. Hossain Rasel, Arman Ullah Rafi, S. M. Moazzem Hossen   +10 more
wiley   +1 more source

Suspected hyperthyroidism‐associated myoclonus in a cat

Veterinary Record Case Reports, Volume 14, Issue 4, November 2026.
Abstract A 10‐year‐old, male, neutered domestic shorthair cat presented with a 2‐week history of progressively worsening myoclonic jerks predominantly involving the head. Jerks were continuous and marked at rest, but became less intense during activity.
Magdalena Maria Dyrka, Ian Ramsey, Fiona May Keir James, Grace Kadler, Jessica Zilli, Rodrigo Gutierrez Quintana   +5 more
wiley   +1 more source

Differences of intensities regarding withdrawal signs in experimental methods For inducing morphine dependency

Journal of Mazandaran University of Medical Sciences, 2009
(Received 25 May, 2009 ; Accepted 10 August, 2009)AbstractBackground and purpose: In the present study, we compared the intensity of physical dependency, mortality rate and weight changes in some common methods for inducing morphine dependency.Materials ...
Ali Shamsizadeh1, Vahid Sheibani, Gholamreza Sepehri, Afrooz Azarang, Azar Namjoo   +4 more
doaj  

A human iPSC-derived midbrain neural stem cell model of prenatal opioid exposure and withdrawal: A proof of concept study.

PLoS ONE
A growing body of clinical literature has described neurodevelopmental delays in infants with chronic prenatal opioid exposure and withdrawal. Despite this, the mechanism of how opioids impact the developing brain remains unknown.
Rhea Sullivan, Quinn Ahrens, Sara L Mills-Huffnagle, Irina A Elcheva, Steven D Hicks   +4 more
doaj   +1 more source

Acute Pain During Intensive Care: Prevalence, Predisposing Factors and Pain Trajectories. A Prospective Multicenter Observational Study

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 9, October 2026.
ABSTRACT Background A considerable proportion of patients in the intensive care unit (ICU) experience pain. The objective of this prospective observational cohort study was to investigate the prevalence of pain, factors associated with pain and pain trajectories in ICU patients.
Aleksandra E. Wlodarczyk‐Abou Elseoud, Maija‐Liisa Kalliomäki, Otto Mäkinen, Annika Laukkanen, Minna Bäcklund, Mitja Lääperi, Katri Hamunen, Anna‐Maria Kuivalainen   +7 more
wiley   +1 more source

Immediate early gene expression during morphine withdrawal

, 1995
The expression of immediate early genes (IEG)s c-fos, c-jun and zif/268 was studied during naloxone-precipitated morphine withdrawal in various organs of the rat.
A.M. Beckmann, Beckmann A.M., P.A. Wilce, Matsumoto I., I. Matsumoto, Wilce P.A.   +5 more
core   +1 more source

Obestatin prevents analgesic tolerance to morphine and reverses the effects of mild morphine withdrawal in mice [PDF]

, 2013
Obestatin is a 23-amino acid gut-derived neuropeptide, encoded by the same gene with ghrelin. The goal of this study was to examine the effects of obestatin on the acute and chronic analgesic actions of morphine and on mild morphine withdrawal.
Szakács Júlia, Lipták Nándor, Dochnal Roberta, Csabafi Krisztina, Szabó Gyula   +4 more
core   +1 more source

Memory retrieval in addiction: a role for miR-105-mediated regulation of D1 receptors in mPFC neurons projecting to the basolateral amygdala

BMC Biology, 2017
Background Drug addiction is a chronic brain disorder characterized by the compulsive use of drugs. The study of chronic morphine-induced adaptation in the brain and its functional significance is of importance to understand the mechanism of morphine ...
Yanfang Zhao, Junfang Zhang, Hualan Yang, Dongyang Cui, Jiaojiao Song, Qianqian Ma, Wenjie Luan, Bin Lai, Lan Ma, Ming Chen, Ping Zheng   +10 more
doaj   +1 more source