Flavonoids Reduce Morphine Withdrawal In-vitro
Journal of Pharmacy and Pharmacology, 1998 AbstractThe effects of quercetin, flavone, catechin and chrysin on the naloxone-precipitated withdrawal contracture of the acute morphine-dependent guinea-pig ileum have been investigated in-vitro.After 4 min in-vitro exposure to morphine a strong contracture of guinea-pig isolated ileum was observed after the addition of naloxone.
CAPASSO, Anna +3 more
openaire +4 more sources
, 2004 The status of the blood-CNS barriers during morphine dependence or withdrawal is still unknown. Morphine-withdrawal is associated with profound stress response, immediate early gene expression in the CNS and alterations in neurochemical metabolism. Thus,
Sharma, Hari Shanker,
core +9 more sources
Effect of Morphine Withdrawal Syndrome on Cerebral Ischemia [PDF]
Iranian Journal of Basic Medical Sciences, 2011 Objective(s)Opioid abuse is still remained a major mental health problem, a criminal legal issue and may cause ischemic brain changes including stroke and brain edema.
Mohammad Allahtavakoli +3 more
doaj +2 more sources
Xylopic acid from Xylopia aethiopica (Annonaceae) inhibits morphine tolerance in rats [PDF]
Pharmaceutical Sciences Asia, 2022 Traditionally, Xylopia aethiopica is used to manage pain disorders such as neuralgia, colic pain, rheumatism and headache. Using animal models, this study aimed to investigate the ability of Xylopic Acid (XA), a kaurene diterpene obtained from Xylopia ...
Priscilla Kolibea Mante +7 more
doaj +1 more source
The effect of 5-HT2A receptor stimulation on morphine withdrawal symptoms in mice [PDF]
مجله علمی دانشگاه علوم پزشکی کردستان, 2023 Background and Aim: Serotonergic system has a role in morphine dependence and withdrawal symptoms via its receptors. On the other hand, the effect of 5-HT2A receptor on withdrawal symptoms has not been evaluated completely.
Nasrin Hashemi-Firouzi +4 more
doaj
Hypothalamic orexin--a neurons are involved in the response of the brain stress system to morphine withdrawal. [PDF]
PLoS ONE, 2012 Both the hypothalamus-pituitary-adrenal (HPA) axis and the extrahypothalamic brain stress system are key elements of the neural circuitry that regulates the negative states during abstinence from chronic drug exposure.
M Luisa Laorden +7 more
doaj +1 more source
Cell Reports, 2021 Summary: Previous work has shown that the paraventricular nucleus of the thalamus (PVT) is an important region that is involved in the conditioned context-induced retrieval of morphine withdrawal memory.
Lanfang Yu +9 more
doaj +1 more source
Involvement of noradrenergic transmission in the PVN on CREB activation, TORC1 levels, and pituitary-adrenal axis activity during morphine withdrawal. [PDF]
PLoS ONE, 2012 Experimental and clinical findings have shown that administration of adrenoceptor antagonists alleviated different aspects of drug withdrawal and dependence. The present study tested the hypothesis that changes in CREB activation and phosphorylated TORC1
Fátima Martín +5 more
doaj +1 more source
Pathological regional blood flow in opiate-dependent patients during withdrawal: A HMPAO-SPECT study [PDF]
, 1998 The aims of the present study were to investigate regional cerebral blood flow (rCBF) in heroin-dependent patients during withdrawal and to assess the relation between these changes and duration of heroin consumption and withdrawal data.
Krappel, C. +9 more
core +1 more source
Role of corticotropin-releasing factor (CRF) receptor-1 on the catecholaminergic response to morphine withdrawal in the nucleus accumbens (NAc). [PDF]
PLoS ONE, 2012 Stress induces the release of the peptide corticotropin-releasing factor (CRF) into the ventral tegmental area (VTA), and also increases dopamine (DA) levels in brain regions receiving dense VTA input.
Pilar Almela +6 more
doaj +1 more source