Differential Changes in Expression of Stress- and Metabolic-Related Neuropeptides in the Rat Hypothalamus during Morphine Dependence and Withdrawal. [PDF]
PLoS ONE, 2013 Chronic morphine treatment and naloxone precipitated morphine withdrawal activates stress-related brain circuit and results in significant changes in food intake, body weight gain and energy metabolism.
Bernadett Pintér-Kübler +6 more
doaj +10 more sources
Projection neurons from medial entorhinal cortex to basolateral amygdala are critical for the retrieval of morphine withdrawal memory [PDF]
iScienceSummary: The medial entorhinal cortex (MEC) is crucial for contextual memory, yet its role in context-induced retrieval of morphine withdrawal memory remains unclear. This study investigated the role of the MEC and its projection neurons from MEC layer 5
Yali Fu +16 more
doaj +2 more sources
YTHDF1 in periaqueductal gray inhibitory neurons contributes to morphine withdrawal responses in mice [PDF]
BMC MedicineBackground Physical symptoms and aversion induced by opioid withdrawal strongly affect the management of opioid addiction. YTH N6-methyladenosine (m6A) RNA binding protein 1 (YTHDF1), an m6A-binding protein, from the periaqueductal gray (PAG) reportedly ...
Chaopeng Ou +8 more
doaj +2 more sources
Impact of Morphine withdrawal on genes related to the TLR2 pathway expressed in the Prefrontal Cortex [PDF]
Science ProgressMillions of people suffer from opioid use disorder, because of the ongoing opioid epidemic. The aversive symptoms of withdrawal are a leading factor for drug relapses, yet there are limited therapeutic options to minimize or prevent withdrawal symptoms ...
Bridget Truitt, Junyi Tao, Sabita Roy
doaj +2 more sources
Effect of Morphine Withdrawal Syndrome on Cerebral Ischemia [PDF]
Iranian Journal of Basic Medical Sciences, 2011 Objective(s)Opioid abuse is still remained a major mental health problem, a criminal legal issue and may cause ischemic brain changes including stroke and brain edema.
Mohammad Allahtavakoli +3 more
doaj +2 more sources
Mitragynine Attenuates Morphine Withdrawal Effects in Rats—A Comparison With Methadone and Buprenorphine [PDF]
Frontiers in Psychiatry, 2020 BackgroundOpiate addiction is a major health problem in many countries. A crucial component of the medical treatment is the management of highly aversive opiate withdrawal signs, which may otherwise lead to resumption of drug taking.
Rahimah Hassan +6 more
doaj +2 more sources
Morphine Withdrawal Enhances HIV Infection of Macrophages. [PDF]
Front Immunol, 2019 Opioid withdrawal recurs at high rates in opioid use disorder and compromises the immune system. In general, there are two types of opioid withdrawal: abrupt withdrawal (AW) and precipitated withdrawal (PW). In this study, we examined the effect of morphine AW or morphine PW on HIV infection of human blood monocyte-derived macrophages. We observed that
Wang X, Liu J, Zhou L, Ho WZ.
europepmc +5 more sources
Opioid Receptors in Immune and Glial Cells-Implications for Pain Control [PDF]
, 2020 Opioid receptors comprise μ (MOP), δ (DOP), κ (KOP), and nociceptin/orphanin FQ (NOP) receptors. Opioids are agonists of MOP, DOP, and KOP receptors, whereas nociceptin/orphanin FQ (N/OFQ) is an agonist of NOP receptors.
Celik, Melih Ö., Machelska, Halina
core +1 more source
Effects of hydroalcoholic extract of Borago officinalis on naloxone-precipitated withdrawal syndrome in morphine-dependent mice [PDF]
, 2016 The aim of the present study was to investigate the effect of hydroalcoholic extract of Borago officinalis on morphine withdrawal syndrome in mice. Morphine-dependent group received morphine for nine days and then received naloxone via intraperitoneal ...
Lorigooini, Zahra. +2 more
core +3 more sources