Results 11 to 20 of about 226,399 (222)

The gut microbiome contributes to somatic morphine withdrawal behavior and implicates a TLR2 mediated mechanism [PDF]

Gut Microbes, 2023
The ongoing opioid epidemic has left millions of people suffering from opioid use disorder due to the over-prescription of highly addictive substances.
Sabita Roy, Junyi Tao
exaly   +4 more sources

AKAP150 from nucleus accumbens dopamine D1 and D2 receptor-expressing medium spiny neurons regulates morphine withdrawal. [PDF]

iScience, 2023
Summary: Dopamine D1 receptor-expressing medium spiny neurons (D1R-MSNs) and dopamine D2 receptor-expressing MSNs (D2R-MSNs) in nucleus accumbens (NAc) have been demonstrated to show different effects on reward and memory of abstinence.
Bai X, Zhang K, Ou C, Mu Y, Chi D, Zhang J, Huang J, Li X, Zhang Y, Huang W, Ouyang H.   +10 more
europepmc   +2 more sources

Effect of Potassium Channel Modulators on Morphine Withdrawal in Mice

Substance Abuse: Research and Treatment, 2010
The present study was conducted to investigate the effect of potassium channel openers and blockers on morphine withdrawal syndrome. Mice were rendered dependent on morphine by subcutaneous injection of morphine; four hours later, withdrawal was induced ...
Vikas Seth, Mushtaq Ahmad, Prerna Upadhyaya, Monika Sharma, Vijay Moghe   +4 more
doaj   +3 more sources

Linagliptin, a Selective Dipeptidyl Peptidase-4 Inhibitor, Reduces Physical and Behavioral Effects of Morphine Withdrawal. [PDF]

Molecules, 2022
(1) Background: Recent data indicate that receptors for GLP-1 peptide are involved in the activity of the mesolimbic system. Thus, the purpose of the present study was to examine the effect of the selective dipeptidyl peptidase-4 (DPP-4) inhibitor ...
Listos J, Listos P, Baranowska-Bosiacka I, Karpiuk A, Filarowska J, Łupina M, Słowik T, Zawiślak S, Kotlińska J.   +8 more
europepmc   +2 more sources

Neural mechanisms underlying morphine withdrawal in addicted patients: a review [PDF]

Reviews in Clinical Medicine, 2015
Morphine is one of the most potent alkaloid in opium, which has substantial medical uses and needs and it is the first active principle purified from herbal source. Morphine has commonly been used for relief of moderate to severe pain as it acts directly
Nima Babhadiashar, Golnaz Vaseghi, Mahmoud Rafieian-Kopaei, Sasan Andalib, Azadeh Eshraghi, Nooshin Masoudian   +5 more
doaj   +4 more sources

Projection neurons from medial entorhinal cortex to basolateral amygdala are critical for the retrieval of morphine withdrawal memory. [PDF]

iScience
Summary: The medial entorhinal cortex (MEC) is crucial for contextual memory, yet its role in context-induced retrieval of morphine withdrawal memory remains unclear. This study investigated the role of the MEC and its projection neurons from MEC layer 5
Fu Y, Cao Z, Ye T, Yang H, Chu C, Lei C, Wen Y, Cai Z, Yuan Y, Guo X, Yang L, Sheng H, Cui D, Shao D, Chen M, Lai B, Zheng P.   +16 more
europepmc   +2 more sources

YTHDF1 in periaqueductal gray inhibitory neurons contributes to morphine withdrawal responses in mice. [PDF]

BMC Med
Background Physical symptoms and aversion induced by opioid withdrawal strongly affect the management of opioid addiction. YTH N6-methyladenosine (m6A) RNA binding protein 1 (YTHDF1), an m6A-binding protein, from the periaqueductal gray (PAG) reportedly ...
Ou C, Zhang K, Mu Y, Huang Z, Li X, Huang W, Wang Y, Zeng W, Ouyang H.   +8 more
europepmc   +2 more sources

Impact of Morphine withdrawal on genes related to the TLR2 pathway expressed in the Prefrontal Cortex. [PDF]

Sci Prog
Millions of people suffer from opioid use disorder, because of the ongoing opioid epidemic. The aversive symptoms of withdrawal are a leading factor for drug relapses, yet there are limited therapeutic options to minimize or prevent withdrawal symptoms ...
Truitt B, Tao J, Roy S.
europepmc   +2 more sources

Mitragynine Attenuates Morphine Withdrawal Effects in Rats-A Comparison With Methadone and Buprenorphine. [PDF]

Front Psychiatry, 2020
BackgroundOpiate addiction is a major health problem in many countries. A crucial component of the medical treatment is the management of highly aversive opiate withdrawal signs, which may otherwise lead to resumption of drug taking.
Hassan R, Pike See C, Sreenivasan S, Mansor SM, Müller CP, Hassan Z.   +5 more
europepmc   +2 more sources

Role of calcium in morphine dependence and naloxone-precipitated withdrawal in mice

Journal of Experimental Pharmacology, 2011
Vikas Seth, Prerna Upadhyaya, Vijay Moghe, Mushtaq AhmadDepartment of Pharmacology, Mahatma Gandhi Medical College, Jaipur, Rajasthan, IndiaPurpose: To explore the role of calcium in morphine withdrawal syndrome using various agents affecting calcium ...
Vikas Seth, Prerna Upadhyaya, Vijay Moghe, et al   +3 more
doaj   +1 more source