Results 11 to 20 of about 6,470,327 (195)
Ventral tegmental area GABA neurons mediate stress-induced blunted reward-seeking in mice
Nature Communications, 2021 Acute stress transiently disrupts reward-seeking behaviour and repeated stress exposure produces lasting anhedonia-like behaviour in rodents. Here, the authors show that stress triggers GABAergic activity in the ventral tegmental area which blunts reward-
Daniel C. Lowes +11 more
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Opiates and Plasticity in the Ventral Tegmental Area [PDF]
ACS Chemical Neuroscience, 2017 Opioids are among the most effective pain relievers; however, their abuse has been on the rise worldwide evident from an alarming increase in accidental opioid overdoses. This demands for an urgent increase in scientific endeavors for better understanding of main cellular mechanisms and circuits involved in opiate addiction.
Ludovic D. Langlois, Fereshteh S. Nugent
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Multiple Personalities in the Ventral Tegmental Area [PDF]
Neuron, 2011 A small number of ventral tegmental area dopamine neurons engage in numerous and apparently contradictory functions--how can this be? A clue is provided by Lammel and colleagues in this issue of Neuron: some VTA dopamine neurons display synaptic plasticity in response to cocaine, and others in response to pain, and these populations are distinguished ...
Borgkvist, Anders +2 more
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Effects of hippocampal damage on reward threshold and response rate during self-stimulation of the ventral tegmental area in the rat [PDF]
, 1999 The main purpose of this study was to explore the role of the hippocampus in motivated behavior. Rats with bilateral excitotoxic lesions of the hippocampus and controls were trained to lever press for electrical stimulation of the ventral tegmental area.
Kelley, Stephen P., Mittleman, Guy
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Mechanisms Underlying Biphasic Effects of Dopamine on Dopaminergic Ventral Tegmental Area Neurons.
, 2011 Mechanisms Underlying Biphasic Effects of Dopamine on Dopaminergic Ventral Tegmental Area ...
Sudarat. Nimitvilai (7978205)
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Immediate early gene expression in the mesopontine tegmentum and midbrain after acute or chronic nicotine administration [PDF]
, 2008 The reinforcing properties of nicotine depend partly on cholinergic projections from the pedunculopontine tegmental (PPTg) and laterodorsal tegmental (LDTg) nuclei to midbrain dopamine neurons in the ventral tegmental area (VTA) and substantia nigra pars
Porter, Ailsa
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Functional neuroanatomical review of the ventral tegmental area [PDF]
NeuroImage, 2019 The ventral tegmental area (VTA) and substantia nigra pars compacta (SNc) are assumed to play a key role in dopamine-related functions such as reward-related behaviour, motivation, addiction and motor functioning. Although dopamine-producing midbrain structures are bordering, they show significant differences in structure and function that argue for a ...
Anne C. Trutti +3 more
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Molecular heterogeneity and development of the ventral tegmental area. [PDF]
Curr Opin Behav SciThe dopaminergic midbrain coordinates vital behaviors required across the lifespan including voluntary movement, learning, and response to rewards. Recent advances in single-cell sequencing technology have enabled detailed transcriptional characterization of the dopaminergic midbrain, including ventral tegmental area and substantia nigra, across ...
Peña CJ, DeBerardine M, Sullivan KE.
europepmc +3 more sources
Glutamatergic Afferents of the Ventral Tegmental Area in the Rat [PDF]
The Journal of Neuroscience, 2007 Glutamatergic inputs to the ventral tegmental area (VTA), thought crucial to the capacity of the VTA to detect and signal stimulus salience, have been reported to arise in but a few structures. However, the afferent system of the VTA comprises very abundant neurons within a large formation extending from the prefrontal cortex to ...
Stefanie, Geisler +3 more
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A Midbrain Circuit that Mediates Headache Aversiveness in Rats
Cell Reports, 2019 Summary: Migraines are a major health burden, but treatment is limited because of inadequate understanding of neural mechanisms underlying headache. Imaging studies of migraine patients demonstrate changes in both pain-modulatory circuits and reward ...
Maggie W. Waung +3 more
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