Results 21 to 30 of about 66,463 (247)

Involvement of mesolimbic dopaminergic network in neuropathic pain relief by treadmill exercise

Molecular Pain, 2016
Background Exercise alleviates pain and it is a central component of treatment strategy for chronic pain in clinical setting. However, little is known about mechanism of this exercise-induced hypoalgesia.
Kenta Wakaizumi MD, Takashige Kondo BS, Yusuke Hamada BS, Michiko Narita BS, Rui Kawabe BS, Hiroki Narita, Moe Watanabe MS, Shigeki Kato PhD, Emiko Senba MD, PhD, Kazuto Kobayashi PhD, Naoko Kuzumaki PhD, Akihiro Yamanaka PhD, Hiroshi Morisaki MD, PhD, Minoru Narita PhD   +13 more
doaj   +1 more source

Superior Colliculus to VTA pathway controls orienting response and influences social interaction in mice

Nature Communications, 2022
Solié, Contestabile et al. show that the superior colliculus to ventral tegmental area (VTA) pathway encodes orienting behavior toward conspecifics, and modulates VTA dopamine neurons projecting onto dorsolateral striatum perturbing social interaction.
Clément Solié, Alessandro Contestabile, Pedro Espinosa, Stefano Musardo, Sebastiano Bariselli, Chieko Huber, Alan Carleton, Camilla Bellone   +7 more
doaj   +1 more source

N,N-Dimethyltryptamine (DMT) Acutely Exposed to Mouse Ventral Tegmental Area I_h-Negative Neurons Alters the Firing Rate and Conductance in a Sex-Dependent Manner. [PDF]

J Neurochem
Depression and substance use disorder are difficult to treat, prompting interest in psychedelics like DMT, though its neural mechanisms remain unclear. This ex vivo study examined acute DMT effects on electrophysiology in male and female Ih‐negative neurons of the mouse ventral tegmental area (VTA). Low‐dose DMT (500 nM) had no effect, whereas a higher
Eliasen JN, Rezagholizadeh A, Jacobsen HP, Kohlmeier KA.   +3 more
europepmc   +2 more sources

A Midbrain Circuit that Mediates Headache Aversiveness in Rats

Cell Reports, 2019
Summary: Migraines are a major health burden, but treatment is limited because of inadequate understanding of neural mechanisms underlying headache. Imaging studies of migraine patients demonstrate changes in both pain-modulatory circuits and reward ...
Maggie W. Waung, Elyssa B. Margolis, Annabelle R. Charbit, Howard L. Fields   +3 more
doaj   +1 more source

Possible multiple evolution of indirect telencephalo-cerebellar pathways in teleosts: studies in Carassius auratus and Pantodon buchholzi [PDF]

, 1993
Among vertebrates, telencephalo-pontine systems exist only in birds and mammals. However, three nuclei in the diencephalon and mesencephalon of teleost fishes have been indicated — analogous to the pons — to represent relay stations between telencephalon
Meyer, Dietrich L., Wullimann, Mario F.
core   +1 more source

The vulnerable ventral tegmental area in Parkinson’s disease [PDF]

Basal Ganglia, 2015
The involvement of dopaminergic neurons in the ventral tegmental area (VTA) in Parkinson's disease (PD) has not been universally recognized by neuroscientists and neurologists. Here, we conduct a review of previous research documenting dopaminergic neuronal loss in both the substantia nigra pars compacta (SNpc) and VTA and add three new post-mortem PD ...
Stephanie L, Alberico, Martin D, Cassell, Nandakumar S, Narayanan   +2 more
openaire   +2 more sources

Cocaine-Induced Endocannabinoid Mobilization in the Ventral Tegmental Area

Cell Reports, 2015
Cocaine is a highly addictive drug that acts upon the brain’s reward circuitry via the inhibition of monoamine uptake. Endogenous cannabinoids (eCB) are lipid molecules released from midbrain dopamine (DA) neurons that modulate cocaine’s effects through ...
Huikun Wang, Tyler Treadway, Daniel P. Covey, Joseph F. Cheer, Carl R. Lupica   +4 more
doaj   +1 more source

Heterogeneous somatostatin-expressing neuron population in mouse ventral tegmental area

eLife, 2020
The cellular architecture of the ventral tegmental area (VTA), the main hub of the brain reward system, remains only partially characterized. To extend the characterization to inhibitory neurons, we have identified three distinct subtypes of somatostatin
Elina Nagaeva, Ivan Zubarev, Carolina Bengtsson Gonzales, Mikko Forss, Kasra Nikouei, Elena de Miguel, Lauri Elsilä, Anni-Maija Linden, Jens Hjerling-Leffler, George J Augustine, Esa R Korpi   +10 more
doaj   +1 more source

Neurobiological Mechanisms That Contribute to Stress-related Cocaine Use [PDF]

, 2014
The ability of stressful life events to trigger drug use is particularly problematic for the management of cocaine addiction due to the unpredictable and often uncontrollable nature of stress.
Ahmed, Ahmed, Ambroggi, Amphoux, Asanuma, Back, Badrinarayan, Barik, Beckerman, Beckstead, Behan, Berridge, Blacktop, Brady, Briand, Brischoux, Broadbear, Brown, Brown, Bruijnzeel, Buffalari, Butts, Campioni, Capriles, Chen, Cintra, Coffey, Conrad, Cottler, Day, de Jong, de Kloet, De La Garza, De Vries, Deroche-Gamonet, Dobi, Dong, Duan, Dumont, Duncan, Egli, Engel, Erb, Erb, Erb, Erb, Erb, Erb, Feltenstein, Forray, Fox, Fox, Galici, Gasser, Gasser, Geisler, Georges, Ghitza, Goeders, Gonzalez-Islas, Gorboulev, Graf, Graf, Gründemann, Hahn, Harfstrand, Iversen, Jayme R. McReynolds, Jennings, Jobes, John R. Mantsch, Jordan M. Blacktop, Kalivas, Kash, Kippin, Koob, Koob, Korotkova, Kreibich, Kudo, Lee, Leri, Lewis, Lodge, Lê, Mantsch, Mantsch, Mantsch, Mantsch, Mantsch, Mantsch, McEwen, McFarland, Nobis, Oleson, Oliver Vranjkovic, Orio, Ostrander, Paul J. Gasser, Preston, Rainbow, Redila, Refojo, Ribeiro Do Couto, Riegel, Robert C. Twining, Rodaros, Roitman, Rounsaville, Saal, Sanchez, Sartor, Schulkin, Seamans, Shaham, Shaham, Shaham, Shalev, Shelton, Shields, Shin, Silberman, Sinha, Sinha, Sinha, Smith, Specio, Steffensen, Tagliaferro, Tasker, Ungless, Ungless, Ungless, Van Pett, Vialou, Vranjkovic, Wanat, Wang, Wang, Wang, Wang, Ward, Wee, Wee, Wei, Wellman, Wise, Yamaguchi, Zahm, Zoli   +149 more
core   +2 more sources

Nicotine addiction : a review [PDF]

, 2013
Nicotine, the major psychoactive compound in tobacco, acts as a potent addictive drug in humans. The addictive nature of nicotine leads to more than 6 million deaths a year.
Di Giovanni, Giuseppe, Vella, Jacob
core   +1 more source