Results 21 to 30 of about 6,470,327 (195)
Cocaine-Induced Endocannabinoid Mobilization in the Ventral Tegmental Area
Cell Reports, 2015 Cocaine is a highly addictive drug that acts upon the brain’s reward circuitry via the inhibition of monoamine uptake. Endogenous cannabinoids (eCB) are lipid molecules released from midbrain dopamine (DA) neurons that modulate cocaine’s effects through ...
Huikun Wang +4 more
doaj +1 more source
Heterogeneous somatostatin-expressing neuron population in mouse ventral tegmental area
eLife, 2020 The cellular architecture of the ventral tegmental area (VTA), the main hub of the brain reward system, remains only partially characterized. To extend the characterization to inhibitory neurons, we have identified three distinct subtypes of somatostatin
Elina Nagaeva +10 more
doaj +1 more source
The vulnerable ventral tegmental area in Parkinson’s disease [PDF]
Basal Ganglia, 2015 The involvement of dopaminergic neurons in the ventral tegmental area (VTA) in Parkinson's disease (PD) has not been universally recognized by neuroscientists and neurologists. Here, we conduct a review of previous research documenting dopaminergic neuronal loss in both the substantia nigra pars compacta (SNpc) and VTA and add three new post-mortem PD ...
Stephanie L, Alberico +2 more
openaire +2 more sources
Projection-Target-Defined Effects of Orexin and Dynorphin on VTA Dopamine Neurons
Cell Reports, 2017 Circuit-specific signaling of ventral tegmental area (VTA) dopamine neurons drives different aspects of motivated behavior, but the neuromodulatory control of these circuits is unclear. We tested the actions of co-expressed lateral hypothalamic peptides,
Corey Baimel +3 more
doaj +1 more source
Nicotine addiction : a review [PDF]
, 2013 Nicotine, the major psychoactive compound in tobacco, acts as a potent addictive drug in humans. The addictive nature of nicotine leads to more than 6 million deaths a year.
Di Giovanni, Giuseppe, Vella, Jacob
core +1 more source
Cell Reports, 2019 Summary: We examine synaptic connectivity and cocaine-evoked plasticity at specific networks within the nucleus accumbens (NAc). We identify distinct subpopulations of D1+ medium spiny neurons (MSNs) that project to either the ventral pallidum (D1+VP) or
Corey Baimel +2 more
doaj +1 more source
A discrete serotonergic circuit regulates vulnerability to social stress
Nature Communications, 2020 Serotonin is important in depression-like behavior. Here the authors show that dorsal raphe neurons that project to the ventral tegmental area are involved in regulating stress responses in mice.
Wen-Jun Zou +14 more
doaj +1 more source
GABAergic and glutamatergic efferents of the mouse ventral tegmental area [PDF]
Journal of Comparative Neurology, 2014 ABSTRACTThe role of dopaminergic (DA) projections from the ventral tegmental area (VTA) in appetitive and rewarding behavior has been widely studied, but the VTA also has documented DA‐independent functions. Several drugs of abuse, act on VTA GABAergic neurons, and most studies have focused on local inhibitory connections.
Taylor, Seth R +5 more
openaire +2 more sources
Neural Plasticity, 2016 We sought to determine the long-term changes produced by neonatal sex hormone administration on the functioning of midbrain dopaminergic neurons in adult male rats.
Pedro Espinosa +9 more
doaj +1 more source
Iron accumulation in the ventral tegmental area in Parkinson's disease
Frontiers in Aging Neuroscience, 2023 IntroductionThe ventral tegmental area (VTA) is less affected compared to substantia nigra pars compacta (SNc) in Parkinson's disease (PD). This study aimed to quantitatively evaluate iron content in the VTA across different stages of PD in order to help
Dongling Zhang +17 more
doaj +1 more source