Results 1 to 10 of about 26,368 (114)

The Lateral Preoptic Area and Its Projection to the VTA Regulate VTA Activity and Drive Complex Reward Behaviors

Frontiers in Systems Neuroscience, 2020
The ventral tegmental area (VTA) underlies motivation and reinforcement of natural rewards. The lateral preoptic area (LPO) is an anterior hypothalamic brain region that sends direct projections to the VTA and to other brain structures known to regulate ...
Michela Marinelli, Adam Gordon-Fennell
exaly   +3 more sources

VTA GABA Neurons at the Interface of Stress and Reward

Frontiers in Neural Circuits, 2019
The ventral tegmental area (VTA) is best known for its robust dopaminergic projections to forebrain regions and their critical role in regulating reward, motivation, cognition, and aversion.
Abigail M Polter
exaly   +3 more sources

Pontomesencephalic Tegmental Afferents to VTA Non-Dopamine Neurons Are Necessary for Appetitive Pavlovian Learning

Cell Reports, 2016
The ventral tegmental area (VTA) receives phenotypically distinct innervations from the pedunculopontine tegmental nucleus (PPTg). While PPTg-to-VTA inputs are thought to play a critical role in stimulus-reward learning, direct evidence linking PPTg-to ...
Hau-jie Yau, Dong V Wang, Karl Deisseroth   +2 more
exaly   +3 more sources

Anatomy and Function of Ventral Tegmental Area Glutamate Neurons

Frontiers in Neural Circuits, 2022
The ventral tegmental area (VTA) is well known for regulating reward consumption, learning, memory, and addiction behaviors through mediating dopamine (DA) release in downstream regions.
Jing Cai, Jing Cai, Qingchun Tong, Qingchun Tong   +3 more
doaj   +1 more source

Reactivating a positive feedback loop VTA-BLA-NAc circuit associated with positive experience ameliorates the attenuated reward sensitivity induced by chronic stress

Neurobiology of Stress, 2021
Both genetic predisposition and life events, particularly life stress, are thought to increase the risk for depression. Reward sensitivity appears to be attenuated in major depressive disorder (MDD), suggesting deficits in reward processing in these ...
Linshan Sun, Jingjing You, Fengjiao Sun, Minghu Cui, Jiangong Wang, Wentao Wang, Dan Wang, Dunjiang Liu, Zhicheng Xu, Changyun Qiu, Bin Liu, Haijing Yan   +11 more
doaj   +1 more source

Distinct signals in medial and lateral VTA dopamine neurons modulate fear extinction at different times

eLife, 2020
Dopamine (DA) neurons are thought to encode reward prediction error (RPE), in addition to other signals, such as salience. While RPE is known to support learning, the role of salience in learning remains less clear.
Lili X Cai, Katherine Pizano, Gregory W Gundersen, Cameron L Hayes, Weston T Fleming, Sebastian Holt, Julia M Cox, Ilana B Witten   +7 more
doaj   +1 more source

Identification of rat ventral tegmental area GABAergic neurons. [PDF]

PLoS ONE, 2012
The canonical two neuron model of opioid reward posits that mu opioid receptor (MOR) activation produces reward by disinhibiting midbrain ventral tegmental area (VTA) dopamine neurons through inhibition of local GABAergic interneurons.
Elyssa B Margolis, Brian Toy, Patricia Himmels, Marisela Morales, Howard L Fields   +4 more
doaj   +1 more source

Output-Specific Adaptation of Habenula-Midbrain Excitatory Synapses During Cocaine Withdrawal

Frontiers in Synaptic Neuroscience, 2021
Projections from the lateral habenula (LHb) control ventral tegmental area (VTA) neuronal populations’ activity and both nuclei shape the pathological behaviors emerging during cocaine withdrawal.
Joseph Clerke, Patricia Preston-Ferrer, Patricia Preston-Ferrer, Ioannis S. Zouridis, Ioannis S. Zouridis, Ioannis S. Zouridis, Audrey Tissot, Laura Batti, Fabian F. Voigt, Fabian F. Voigt, Stephane Pagès, Andrea Burgalossi, Andrea Burgalossi, Manuel Mameli, Manuel Mameli   +14 more
doaj   +1 more source

Alteration in ventral tegmental area and default mode network interplay and prediction of coma recovery in patients with sTBI

Heliyon, 2023
Purpose: To investigate the role of VTA and DMN in modulating human consciousness in patient with sTBI. Methods: We mapped an atlas of VTA in the brainstem and a total of 19 region of interests in the ventral and dorsal DMN onto functional magnetic ...
Canxin Xu, RuiZhe Zheng, LaiYang Zhou, DongFu Feng   +3 more
doaj   +1 more source

Control of Behavioral Arousal and Defense by a Glutamatergic Midbrain-Amygdala Pathway in Mice

Frontiers in Neuroscience, 2022
In response to external threatening signals, animals evolve a series of defensive behaviors that depend on heightened arousal. It is believed that arousal and defensive behaviors are coordinately regulated by specific neurocircuits in the central nervous
Shang-Yi Chen, Jing Yao, Yu-Duan Hu, Hui-Yun Chen, Pei-Chang Liu, Wen-Feng Wang, Yu-Hang Zeng, Cong-Wen Zhuang, Shun-Xing Zeng, Yue-Ping Li, Liu-Yun Yang, Zi-Xuan Huang, Kai-Qi Huang, Zhen-Ting Lai, Yong-Huai Hu, Ping Cai, Li Chen, Siying Wu   +17 more
doaj   +1 more source