Results 41 to 50 of about 34,623 (230)

Dose- and time-dependent effects of the dual GIP/GLP-1 receptor agonist tirzepatide on emotional overeating in a rat model of intracranial self-stimulation

Acta Biomedica Scientifica
Background. Despite the increasing prevalence of emotional overeating and obesity, the specific neurohormonal mechanisms involved in the pathogenesis of these pathological processes remain poorly understood.
N. S. Dedanishvili, S. S. Pyurveev, T. V. Brus, A. G. Vasiliev   +3 more
doaj   +1 more source

Vesicular glutamate transporter 2 expression in the ventral tegmental area of outbred male rats following exposure to nicotine and alcohol

Drug and Alcohol Dependence Reports, 2023
Background: Initiation of use/co-use of nicotine and alcohol, commonly occurring in an episodic manner during adolescence, can imprint vulnerability to the developing brain and lead to addiction.
Maria Vrettou, Stefan Bernhard Thalhammer, Anne-Lie Svensson, Sylvie Dumas, Kent W Nilsson, Åsa Wallén-Mackenzie, Robert Fredriksson, Ingrid Nylander, Erika Comasco   +8 more
doaj   +1 more source

Ventral tegmental area afferents and drug-dependent behaviors

Frontiers in Psychiatry, 2016
Drug-related behaviors in both humans and rodents are commonly thought to arise from aberrant learning processes. Preclinical studies demonstrate that the acquisition and expression of many drug-dependent behaviors involves the ventral tegmental area ...
Idaira eOliva, Matthew eWanat
doaj   +1 more source

An atlas of transcriptionally defined cell populations in the rat ventral tegmental area

Cell Reports, 2022
Summary: The ventral tegmental area (VTA) is a complex brain region that is essential for reward function and frequently implicated in neuropsychiatric disease.
Robert A. Phillips, III, Jennifer J. Tuscher, Samantha L. Black, Emma Andraka, N. Dalton Fitzgerald, Lara Ianov, Jeremy J. Day   +6 more
doaj   +1 more source

Sensory cues potentiate VTA dopamine mediated reinforcement

eneuro, 2023
Sensory cues are critical for shaping decisions and invigorating actions during reward seeking. Dopamine neurons in the ventral tegmental area (VTA) are critical in this process, supporting associative learning in Pavlovian and instrumental settings.
Amy R. Wolff, Benjamin T. Saunders
openaire   +3 more sources

Polyethylene Glycol Cross-Linked Hydrogel for Drug Absorption Properties

Journal of Pharmacy and Bioallied Sciences
Three-dimensional polymeric networks called hydrogels have drawn a lot of interest in a variety of biomedical applications because of their distinctive qualities, like high water content and biocompatibility.
Durairaj VTA, Kalpana R
doaj   +1 more source

Ventral tegmental area interneurons revisited: GABA and glutamate projection neurons make local synapses

eLife
The ventral tegmental area (VTA) contains projection neurons that release the neurotransmitters dopamine, GABA, and/or glutamate from distal synapses. VTA also contains GABA neurons that synapse locally on to dopamine neurons, synapses widely credited to
Lucie Oriol, Melody Chao, Grace J Kollman, Dina S Dowlat, Sarthak M Singhal, Thomas Steinkellner, Thomas S Hnasko   +6 more
doaj   +1 more source

Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation

eLife, 2015
One reported mechanism for morphine activation of dopamine (DA) neurons of the ventral tegmental area (VTA) is the disinhibition model of VTA-DA neurons.
Ming Chen, Yanfang Zhao, Hualan Yang, Wenjie Luan, Jiaojiao Song, Dongyang Cui, Yi Dong, Bin Lai, Lan Ma, Ping Zheng   +9 more
doaj   +1 more source

Opioid Modulation of Major Neurotransmitter Systems: Acute, Chronic, and Withdrawal Effects. [PDF]

Eur J Neurosci
Opioids are widely used but also frequently misused drugs that affect multiple neurotransmitter systems, including dopaminergic, glutamatergic, GABAergic, serotonergic, and cholinergic pathways. Opioid‐induced neuroadaptations depend on the duration of drug exposure, with distinct changes also emerging following drug discontinuation.
Novakova D, Pritulova E, Novotny J.
europepmc   +2 more sources

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source