Results 61 to 70 of about 34,623 (230)

VTA CB1R mediates cannabinoid-facilitated LTD induction in the VTA.

, 2013
(A) Systemic pretreatment with the selective CB1R antagonist AM281 prior to daily HU210 injection blocked LFS-induced LTD in the VTA. (B) Localization of bilaterally microfusioned adenoviral vectors containing GFP into the VTA. Scale bar: 150 µm.
Zul Merali (126741), Robert Monette (358667), Guang Bai (358665), Wandong Zhang (133483), Zhengping Jia (267394), Jing Han (43038), Zhou Zhu (46647), Xia Zhang (41398), Zhiqiang Liu (182265), Qiaohua Zheng (358666), Lin Xu (94491), Lintao Jia (358663), Wei Ren (267391), Wei Wang (17594), Jean-Christian Maillet (358664)   +14 more
core   +1 more source

Neurotensin Receptor-1 Identifies a Subset of Ventral Tegmental Dopamine Neurons that Coordinates Energy Balance

Cell Reports, 2017
Dopamine (DA) neurons in the ventral tegmental area (VTA) are heterogeneous and differentially regulate ingestive and locomotor behaviors that affect energy balance. Identification of which VTA DA neurons mediate behaviors that limit weight gain has been
Hillary L. Woodworth, Hannah M. Batchelor, Bethany G. Beekly, Raluca Bugescu, Juliette A. Brown, Gizem Kurt, Patrick M. Fuller, Gina M. Leinninger   +7 more
doaj   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Design and characteristics of the prophylactic intra‐operative ventricular arrhythmia ablation in high‐risk LVAD candidates (PIVATAL) trial

Annals of Noninvasive Electrocardiology, 2023
Background The use of a Left Ventricular Assist Device (LVAD) in patients with advanced heart failure refractory to optimal medical management has progressed steadily over the past two decades. Data have demonstrated reduced LVAD efficacy, worse clinical
David T. Huang, Igor Gosev, Katherine L. Wood, Hima Vidula, William Stevenson, Frank Marchlinski, Gregory Supple, Sandip K. Zalawadiya, J. Peter Weiss, Roderick Tung, Wendy S. Tzou, Joshua D. Moss, Krishna Kancharla, Sunit‐Preet Chaudhry, Parin J. Patel, Arfaat M. Khan, Claudio Schuger, Guy Rozen, Michael S. Kiernan, Gregory S. Couper, Marzia Leacche, Ezequiel J. Molina, Anand D. Shah, Michael Lloyd, Jakub Sroubek, Edward Soltesz, Kalyanam Shivkumar, Casey White, Sinan Tankut, Brent A. Johnson, Scott McNitt, Valentina Kutyifa, Wojciech Zareba, Ilan Goldenberg   +33 more
doaj   +1 more source

Regulation of cocaine seeking behavior by locus coeruleus noradrenergic activity in the ventral tegmental area is time- and contingency-dependent

Frontiers in Neuroscience, 2022
Substance use disorder is linked to impairments in the ventral tegmental area (VTA) dopamine (DA) reward system. Noradrenergic (NA) inputs from locus coeruleus (LC) into VTA have been shown to modulate VTA neuronal activity, and are implicated in ...
Wojciech B. Solecki, Michał Kielbinski, Michał Wilczkowski, Michał Wilczkowski, Katarzyna Zajda, Karolina Karwowska, Bernacka Joanna, Zenon Rajfur, Ryszard Przewłocki   +8 more
doaj   +1 more source

Periaqueductal efferents to dopamine and GABA neurons of the VTA

, 2017
Neurons in the periaqueductal gray (PAG) modulate threat responses and nociception. Activity in the ventral tegmental area (VTA) on the other hand can cause reinforcement and aversion.
Christian Lüscher, Niels R. Ntamati, Meaghan Creed   +2 more
core   +1 more source

Context-Dependent Multiplexing by Individual VTA Dopamine Neurons [PDF]

The Journal of Neuroscience, 2018
Abstract Dopamine (DA) neurons of the ventral tegmental area (VTA) track external cues and rewards to generate a reward prediction error (RPE) signal during Pavlovian conditioning. Here we explored how RPE is implemented for a self-paced, operant task in freely moving mice. The animal could trigger a reward-predicting
Yves Kremer, Jérôme Flakowski, Clément Rohner, Christian Lüscher   +3 more
openaire   +4 more sources

The Response of Ventral Tegmental Area Dopaminergic Neurons to Bupropion: Excitation or Inhibition?

Basic and Clinical Neuroscience, 2019
Introduction: Antidepressants can modulate brain monoamines by acting on pre-synaptic and postsynaptic receptors. Autoreceptors can reduce the monoamines effect on the somatodendritic or pre-synaptic regions despite its postsynaptic counter effects.
Shirin Sadighparvar, Fereshteh Tale, Parviz Shahabi, Somayyeh Naderi, Firouz Ghaderi Pakdel   +4 more
doaj  

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

Motor skill learning and reward consumption differentially affect VTA activation [PDF]

, 2018
Dopamine release from the ventral tegmental area (VTA) terminals in the primary motor cortex (M1) enables motor skill acquisition. Here, we test the hypothesis that dopaminergic VTA neurons projecting to M1 are activated when rewards are obtained during ...
Luft, Andreas, Canonica, Tara, Susan Leemburg, Andreas Luft, Tara Canonica, Leemburg, Susan, Leemburg S, Luft A, Canonica T   +8 more
core   +1 more source