Results 81 to 90 of about 34,623 (230)

Remote Versus In‐Person Follow‐up Programming After Subthalamic Deep Brain Stimulation for Parkinson's Disease: A Multicenter Randomized Noninferiority Trial

Movement Disorders, EarlyView.
Abstract Background Remote programming of deep brain stimulation may improve access to specialized postoperative care for people with Parkinson's disease, but prospective randomized evidence remains limited. Objective We aimed to determine whether remote follow‐up programming after standardized inpatient initiation is noninferior to conventional in ...
Juhi Shaik, Weidong Zhang, Verena Zentsch, Carsten Buhmann, Ute Hidding, Thomas M. Kinfe, Martin Regensburger, Jost‐Julian Rumpf, Alfons Schnitzler, Jing Dong, Maximilian Scherer, Elisabeth Kaufmann, Johannes Levin, Alexander Crispin, Günter Höglinger, Jan H. Mehrkens, Thomas Koeglsperger   +16 more
wiley   +1 more source

VTA-insula Connectivity and Avolition in Subjects with Schizophrenia

European Psychiatry, 2017
IntroductionAvolition represents an important domain of negative symptoms in schizophrenia with a strong impact on functional outcome. Primary and persistent avolition is refractory to available pharmacological and psychological treatments. A better understanding of its pathophysiological mechanisms is fundamental to promote development of new ...
Mucci, A., Giordano, G. M., Stanziano, M., Papa, M., Galderisi, S.   +4 more
openaire   +1 more source

Stress andVTAsynapses: implications for addiction and depression [PDF]

European Journal of Neuroscience, 2014
AbstractWhile stressful experiences are a part of everyone's life, they can also exact a major toll on health. Stressful life experiences are associated with increased substance abuse, and there exists significant co‐morbidity between mental illness and substance use disorders [N.D. Volkow & T.K. Li (2004)Nat. Rev. Neurosci.,5, 963–970; G.
Abigail M, Polter, Julie A, Kauer
openaire   +2 more sources

Distinct ventral tegmental area neuronal ensembles are indispensable for reward-driven approach and stress-driven avoidance behaviors

Nature Communications
Assigning valence to stimuli for adaptive behavior is an essential function, involving the ventral tegmental area (VTA). VTA cell types are often defined through neurotransmitters (NT).
Ioannis Koutlas, Lefkothea Patrikiou, Stef E. van der Starre, Diaz Danko, Inge G. Wolterink-Donselaar, Mieneke C. M. Luijendijk, Roger A. H. Adan, Frank J. Meye   +7 more
doaj   +1 more source

The cation channel mechanisms of subthreshold inward depolarizing currents in the mice VTA dopaminergic neurons and their roles in the chronic-stress-induced depression-like behavior

eLife
The slow-intrinsic-pacemaker dopaminergic (DA) neurons originating in the ventral tegmental area (VTA) are implicated in various mood- and emotion-related disorders, such as anxiety, fear, stress and depression.
Jing Wang, Min Su, Dongmei Zhang, Ludi Zhang, Chenxu Niu, Chaoyi Li, Shuangzhu You, Yuqi Sang, Yongxue Zhang, Xiaona Du, Hailin Zhang   +10 more
doaj   +1 more source

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

5-HT(2C) receptors localize to dopamine and GABA neurons in the rat mesoaccumbens pathway. [PDF]

PLoS ONE, 2011
The serotonin 5-HT(2C) receptor (5-HT(2C)R) is localized to the limbic-corticostriatal circuit, which plays an integral role in mediating attention, motivation, cognition, and reward processes.
Marcy J Bubar, Sonja J Stutz, Kathryn A Cunningham   +2 more
doaj   +1 more source

Systematic analysis of expression signatures of neuronal subpopulations in the VTA [PDF]

Molecular Brain, 2019
AbstractGene expression profiling across various brain areas at the single-cell resolution enables the identification of molecular markers of neuronal subpopulations and comprehensive characterization of their functional roles. Despite the scientific importance and experimental versatility, systematic methods to analyze such data have not been ...
Hyun Jin Kim, Minhyung Kim, Byeongsoo Kang, Soyeon Yun, Shin Eun Ryeo, Daehee Hwang, Joung-Hun Kim   +6 more
openaire   +3 more sources

SIRT1 Mediates Neuropathic Pain Induced by Sciatic Nerve Chronic Constrictive Injury in the VTA-NAc Pathway

Pain Research and Management, 2020
Background. Mounting evidence has shown that sirtuin 1 (SIRT1), a class III histone deacetylase, alleviated several types of neuropathic pain in the spinal cord and dorsal root ganglion and regulated some aberrant behaviors in the ventral tegmental area (
Yangyang Li, Lei Wang, Guotao Zhang, Xueli Qiao, Mingxing Zhang   +4 more
doaj   +1 more source

Dopamine: The Essential Bridge Mediating Obstructive Sleep Apnea and Hippocampus‐Dependent Learning and Memory Impairments

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Obstructive sleep apnea is a clinical syndrome that triggers a series of pathophysiologic changes, including disturbed sleep architecture, chronic intermittent hypoxia and hypercapnia, and ultimately severe cognitive dysfunction. The hippocampus plays a key role in various cognitive processes such as learning and memory.
Rui Fan, Tao Li, Yan Yan
wiley   +1 more source