Results 101 to 110 of about 34,623 (230)

Bioengineered microbiotic levodopa therapy improves cognition and reduces pathology in a rat model of Alzheimer's disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Degeneration of the pontine noradrenergic and midbrain dopaminergic systems contributes to cognitive‐behavioural disturbances during the prodromal stages of Alzheimer's disease (AD). We developed a genetically engineered, programmable probiotic Escherichia coli Nissle 1917 strain (EcNrhaL‐DOPA) capable of producing L‐3,4 ...
Mona Abdelhamid, Piyush Padhi, Mahsa Gifani, John S. Beck, Jacob P. Thomas, Gargi Khadse, Catherine Kudela, Gregory J. Phillips, Anumantha G. Kanthasamy, Scott E. Counts   +9 more
wiley   +1 more source

The dual incretin agonist tirzepatide blunts nicotine‐induced behaviours and neurochemistry in male mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Nicotine dependence remains one of the leading causes of morbidity and mortality worldwide, with high relapse rates and post‐cessation weight gain representing persistent barriers to sustained abstinence. The incretin hormones glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1) have ...
Christian E. Edvardsson, Thaynnam A. Emous, Sarah Witley, Mia Ericson, Louise Adermark, Elisabet Jerlhag   +5 more
wiley   +1 more source

Amylin Receptor Signalling in the Laterodorsal Tegmental Nucleus Controls Food Intake Through Projections to the Ventral Tegmental Area

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background The role of amylin signalling in energy balance control has been understudied in calcitonin receptor (CTR) expressing nuclei such as the mesopontine laterodorsal tegmental nucleus (LDTg). Our lab has shown that LDTg amylin signalling reduces feeding and body weight, but the neuronal phenotype and downstream targets of LDTgCTR cells ...
Marcos J. Sanchez Navarro, Carlie Zhang, Samantha M. Fortin, Matthew R. Hayes   +3 more
wiley   +1 more source

Fluoride‐Free Mouthwashes Available Over‐The‐Counter in the US‐An Overview

International Journal of Dental Hygiene, EarlyView.
ABSTRACT Purpose Fluoride‐free mouthwashes (FFM) are commonly used by patients for a variety of cosmetic and/or therapeutic reasons. The purpose of this study was to investigate the composition and purposes of FFM available over‐the‐counter in the US.
Astrid C. Valdivia‐Tapia, Jaime A. Cury, Antonio P. Ricomini‐Filho, Frank Lippert   +3 more
wiley   +1 more source

Ventral Tegmental Area GABA Neurons Are Resistant to GABA(A) Receptor-Mediated Inhibition During Ethanol Withdrawal

Frontiers in Neuroscience, 2018
The neural mechanisms underlying alcohol dependence are not well-understood. GABAergic neurons in the ventral tegmental area (VTA) are a relevant target for ethanol.
Ashley C. Nelson, Stephanie B. Williams, Stephanie S. Pistorius, Hyun J. Park, Taylor J. Woodward, Andrew J. Payne, J. Daniel Obray, Samuel I. Shin, Jennifer K. Mabey, Scott C. Steffensen   +9 more
doaj   +1 more source

Antagonism of GABA-B but not GABA-A receptors in the VTA prevents stress- and intra-VTA CRF-induced reinstatement of extinguished cocaine seeking in rats [PDF]

, 2016
Stress-induced reinstatement of cocaine seeking requires corticotropin releasing factor (CRF) actions in the ventral tegmental area (VTA). However the mechanisms through which CRF regulates VTA function to promote cocaine use are not fully understood ...
Hoof, Matthew Van, Baker, David A., Mantsch, John R., Blacktop, Jordan M., Mayer, Matthieu, Vranjkovic, Oliver   +5 more
core  

The PFC-LH-VTA pathway contributes to social deficits in IRSp53-mutant mice

, 2023
Dopamine (DA) neurons in the ventral tegmental area (VTA) promote social brain functions by releasing DA onto nucleus accumbens neurons, but it remains unclear how VTA neurons communicate with cortical neurons.
Jae Jin Shin, Kim, Yangsik, Noh, Young Woo, Eunjoon Kim, Kim, Il Hwan, Kang, Hyojin, Lee, Soowon, Kim, Yeonghyeon   +7 more
core   +1 more source

Activation of VTA GABA Neurons Disrupts Reward Consumption [PDF]

, 2012
SummaryThe activity of ventral tegmental area (VTA) dopamine (DA) neurons promotes behavioral responses to rewards and environmental stimuli that predict them.
Phillips, Jana L., Stuber, Garret D., Van Zessen, Ruud, Budygin, Evgeny A.   +3 more
core   +1 more source

Stress resilience is associated with transcriptional remodeling in the VTA

Cell Reports
Summary Individual responses to chronic stress vary, with some individuals remaining resilient while others exhibit susceptibility. The ventral tegmental area (VTA), a region involved in reward learning, and the lateral habenula (LHb), a region involved in aversive learning, have been implicated in the pathophysiology of stress-related ...
Adelaide R. Minerva, Brenna McMannon, Rixing Lin, Anna Zhukovskaya, Ilana B. Witten, Catherine Jensen Peña   +5 more
openaire   +4 more sources

Associations between mesolimbic connectivity, and alcohol use from adolescence to adulthood

Developmental Cognitive Neuroscience
Dopaminergic projections from the ventral tegmental area (VTA) to limbic regions play a key role in the initiation and maintenance of substance use; however, the relationship between mesolimbic resting-state functional connectivity (RSFC) and alcohol use
Angelica M. Morales, Scott A. Jones, Birgitta Carlson, Dakota Kliamovich, Joseph Dehoney, Brooke L. Simpson, Kalene A. Dominguez-Savage, Kristina O. Hernandez, Daniel A. Lopez, Fiona C. Baker, Duncan B. Clark, David B. Goldston, Beatriz Luna, Kate B. Nooner, Eva M. Muller-Oehring, Susan F. Tapert, Wesley K. Thompson, Bonnie J. Nagel   +17 more
doaj   +1 more source