Results 111 to 120 of about 34,623 (230)

Cortical Control Of Vta Function And Influence On Nicotine Reward

, 2013
Tobacco use is a major public health problem. Nicotine acts on widely distributed nicotinic acetylcholine receptors (nAChRs) in the brain and excites dopamine (DA) neurons in the ventral tegmental area (VTA). The elicited increase of DA neuronal activity
Gutkin, Boris, Shi, Wei Xing, Gao, Ming, Wu, Jie, Shen, Jian-Xin, Shi, Wei-Xing, Oster, Andrew, Gutkin, Boris S., Shen, Jian Xin, Oster, Andrew M.   +9 more
core   +1 more source

VTA-forebrain connectivity moderates adaptive behavior

Brain Structure and Function
Abstract Neural representation of the environment is pertinent for adaptive behaviors. Such neural maps are processed in the hippocampus and contain information about spatial locations, novelties, context, and cues for context discrimination.
Sinza, Sadia Islam, Choi, Kwon, Lim, Ignitius Ezekiel, Williams, Madison Ashley, Ogundele, Olalekan Michael   +4 more
openaire   +2 more sources

Mapping VTA neural circuits: periaqueductal inputs and mesohippocampal outputs

, 2017
Understanding how the ventral tegmental area (VTA) shapes behaviour to avoid aversive stimuli and seek reward requires knowledge of its input and output connectivity within the network of brain structures collectively known as the reward system.
Ntamati Rwaka, Niels
core   +1 more source

Mesopontine cholinergic inputs to midbrain dopamine neurons drive stress-induced depressive-like behaviors

Nature Communications, 2018
Dopamine neurons in the ventral tegmental area (VTA) are implicated in depressive-like behaviors. Here, the authors show that cholinergic inputs to the VTA from the laterodorsal tegmentum regulate intrinsic plasticity of VTA DA neurons to mediate stress ...
Sebastian P. Fernandez, Loïc Broussot, Fabio Marti, Thomas Contesse, Xavier Mouska, Mariano Soiza-Reilly, Hélène Marie, Philippe Faure, Jacques Barik   +8 more
doaj   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Activation of RMTg projections to the VTA reverse cocaine-induced molecular adaptation in the reward system

Translational Psychiatry
The rostromedial tegmental nucleus (RMTg) plays a crucial role in regulating reward-related behavior by exerting inhibitory control over the ventral tegmental area (VTA).
A. Khayat, R. Yaka
doaj   +1 more source

The projection from the prelimbic cortex to the ventral tegmental area negatively regulates 5-HT-induced itch-scratching and positively regulates itch-related aversion in rats

Brain Research Bulletin
Direct and indirect evidence suggests that the prelimbic cortex (PrL) and the ventral tegmental area (VTA) are the key brain regions involved in the regulation of itch sensation and itch-related emotions.
Xing-Yu Lu, Jun-Fei Teng, Juan Yao, Xuan Li, Bing Wu, Xue-Qiang Hu, Ping Wang, Xiao-Qian Jiang, Jian-Feng Sui, Ke-Hui Hu, Yue-Ming Xu, Shu-Lei Liu   +11 more
doaj   +1 more source

Development and validation of the felt safeness in the therapeutic relationship questionnaire

Psychology and Psychotherapy: Theory, Research and Practice, EarlyView.
Abstract Objective To develop and evaluate the Felt Safeness in the Therapeutic Relationship Questionnaire (FSTRQ), a novel measure of someone's sense of social safeness within the therapeutic relationship. Method 226 participants completed online questionnaires including FSTRQ and measures of overall social safeness, therapeutic alliance, positive ...
Emily Hesselink, Jasmin Langdon‐Daly
wiley   +1 more source

Effects of 14 days of head‐down bed rest with or without exercise, and subsequent recovery on bone turnover, density and structure in older adults

Experimental Physiology, EarlyView.
Abstract Bed rest accelerates bone loss and may exacerbate skeletal fragility. This study examined the effects of 14 days of head‐down tilt bed rest (HDBR) with or without exercise, and subsequent recovery, on bone turnover, density and structure in older adults. Twenty‐two healthy older adults (55–65 years) completed the HDBR protocol.
Guy Hajj‐Boutros, Andréa Faust, Carmelo Mastrandrea, Vita Sonjak, Dounia Rouabhia, Gustavo Duque, Richard Kremer, Stéphanie Chevalier, Julie Lacombe, Mathieu Ferron, Tyler A. Churchward‐Venne, José A. Morais   +11 more
wiley   +1 more source

Adaptations of glucagon‐like peptide‐1 receptor agonist‐induced weight loss, drivers of weight regain and future directions of therapeutics

The Journal of Physiology, EarlyView.
Abstract figure legend During GLP‐1RA treatment reduced appetite and energy intake, delayed gastric emptying, decreased visceral fat mass and improved glycaemic control contribute to weight loss. After treatment cessation these benefits are partially or completely reversed, resulting in weight regain, accompanied by increased appetite and energy intake,
Camille E. M. Piguet, Rosie Nucci, Jacqueline L. Beaudry   +2 more
wiley   +1 more source