Results 1 to 10 of about 27,540 (239)
Association between Chronic Pain and Alterations in the Mesolimbic Dopaminergic System
Brain Sciences, 2020 Chronic pain (pain lasting for >3 months) decreases patient quality of life and even occupational abilities. It can be controlled by treatment, but often persists even after management.
Yoo Jin Choo +2 more
exaly +3 more sources
Frontiers in Human Neuroscience, 2021 Neuro-ethological studies conducted by Panksepp and his colleagues have provided an understanding of how the activity of the mesolimbic dopaminergic (ML DA) system leads to the emotional disposition to SEEK/Explore, which is involved in all appetitive ...
Antonio Alcaro +2 more
doaj +1 more source
Insulin sensitivity in mesolimbic pathways predicts and improves with weight loss in older dieters
eLife, 2022 Central insulin is critically involved in the regulation of hedonic feeding. Insulin resistance in overweight has recently been shown to reduce the inhibitory function of insulin in the human brain.
Lena J Tiedemann +5 more
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The VTA dopaminergic system as diagnostic and therapeutical target for Alzheimer's disease
Frontiers in Psychiatry, 2022 Neuropsychiatric symptoms (NPS) occur in nearly all patients with Alzheimer's Disease (AD). Most frequently they appear since the mild cognitive impairment (MCI) stage preceding clinical AD, and have a prognostic importance. Unfortunately, these symptoms
Paraskevi Krashia +4 more
doaj +1 more source
Frontiers in Psychiatry, 2022 Diminished motivation to pursue and obtain primary and secondary rewards has been demonstrated in anorexia nervosa (AN). However, the neurobehavioral mechanisms underlying the behavioral activation component of aberrant reward motivation remains ...
Reza Tadayonnejad +17 more
doaj +1 more source
Cell Reports, 2017 Dopamine (DA) neurons in the ventral tegmental area (VTA) are heterogeneous and differentially regulate ingestive and locomotor behaviors that affect energy balance. Identification of which VTA DA neurons mediate behaviors that limit weight gain has been
Hillary L. Woodworth +7 more
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Dopamine downregulation in novel rodent models useful for the study of postpartum depression
Frontiers in Behavioral Neuroscience, 2022 Postpartum depression (PPD) is the most common psychiatric disorder following childbirth and is characterized by maternal mood disturbances, impaired maternal responses, and disrupted caregiving- all of which negatively impact offspring development ...
Millie Rincón-Cortés, Anthony A. Grace
doaj +1 more source
Metabolism of Dopamine in Nucleus Accumbens Astrocytes Is Preserved in Aged Mice Exposed to MPTP
Frontiers in Aging Neuroscience, 2017 Parkinson disease (PD) is prevalent in elderly individuals and is characterized by selective degeneration of nigrostriatal dopamine (NSDA) neurons. Interestingly, not all dopamine (DA) neurons are affected equally by PD and aging, particularly mesolimbic
Brittany M. Winner +11 more
doaj +1 more source
Hippocampal Hyperactivity as a Druggable Circuit-Level Origin of Aberrant Salience in Schizophrenia
Frontiers in Pharmacology, 2020 The development of current neuroleptics was largely aiming to decrease excessive dopaminergic signaling in the striatum. However, the notion that abnormal dopamine creates psychotic symptoms by causing an aberrant assignment of salience that drives ...
Dennis Kätzel +3 more
doaj +1 more source
Reviewing the mechanism of propofol addiction
All Life, 2023 Propofol is widely used as a short-acting intravenous anaesthetic for the induction and maintenance of anaesthetic sedation. The application of propofol is expanding due to its advantages and the increasing demand for painless diagnosis and treatment ...
Tianhao Zhong +5 more
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