Sex differences in pre- and post-synaptic glutamate signaling in the nucleus accumbens core
Biology of Sex Differences, 2023 Background Glutamate signaling within the nucleus accumbens underlies motivated behavior and is involved in psychiatric disease. Although behavioral sex differences in these processes are well-established, the neural mechanisms driving these differences ...
Melissa C. Knouse +4 more
doaj +1 more source
Overlapping Prediction Errors in Dorsal Striatum During Instrumental Learning With Juice and Money Reward in the Human Brain [PDF]
, 2009 Prediction error signals have been reported in human imaging studies in target areas of dopamine neurons such as ventral and dorsal striatum during learning with many different types of reinforcers. However, a key question that has yet to be addressed is
O'Doherty, John P., Valentin, Vivian V.
core +2 more sources
Gut Microbes, 2022 The prevalence of obesity has risen to its highest values over the last two decades. While many studies have either shown brain or microbiome connections to obesity, few have attempted to analyze the brain-gut-microbiome relationship in a large cohort ...
Tien S. Dong +10 more
doaj +1 more source
Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain. [PDF]
, 2015 © 2015 The Authors.Objective: Although Glucagon-like peptide 1 is a key regulator of energy metabolism and food intake, the precise location of GLP-1 receptors and the physiological relevance of certain populations is debatable.
Cork, SC +5 more
core +2 more sources
The Nucleus Accumbens: A Comprehensive Review [PDF]
Stereotactic and Functional Neurosurgery, 2015 There is increasing interest among functional neurosurgeons in the potential for novel therapies to impact upon diseases beyond movement disorders and pain. A target of increasing interest is the nucleus accumbens (NAc), which has long been studied as a key brain region mediating a variety of behaviors, including reward and satisfaction. As such, focal
Sanjay, Salgado, Michael G, Kaplitt
openaire +2 more sources
Blunted Cystine–Glutamate Antiporter Function in the Nucleus Accumbens Promotes Cocaine-induced Drug Seeking [PDF]
, 2008 Repeated cocaine alters glutamate neurotransmission, in part, by reducing cystine–glutamate exchange via system xc−, which maintains glutamate levels and receptor stimulation in the extrasynaptic compartment.
Abdulhameed, Omer +5 more
core +1 more source
Increased colonic propionate reduces anticipatory reward responses in the human striatum to high-energy foods [PDF]
, 2016 Background: Short-chain fatty acids (SCFAs), metabolites produced through the microbial fermentation of nondigestible dietary components, have key roles in energy homeostasis.
Alhabeeb, Habeeb +14 more
core +1 more source
Neuropsychopharmacology Reports, 2019 Aim Repeated psychostimulant drug treatment, including methamphetamine, in rodents readily produces behavioral sensitization, which reflects altered brain function caused by repeated drug exposure.
Yoshiyuki Kasahara +7 more
doaj +1 more source
History of early life adversity is associated with increased food addiction and sex-specific alterations in reward network connectivity in obesity. [PDF]
, 2019 Background:Neuroimaging studies have identified obesity-related differences in the brain's resting state activity. An imbalance between homeostatic and reward aspects of ingestive behaviour may contribute to obesity and food addiction.
Bhatt, R +10 more
core +1 more source
Endogenous Dopamine and Endocannabinoid Signaling Mediate Cocaine-Induced Reversal of AMPAR Synaptic Potentiation in the Nucleus Accumbens Shell [PDF]
, 2018 Repeated exposure to drugs of abuse alters the structure and function of neural circuits mediating reward, generating maladaptive plasticity in circuits critical for motivated behavior.
Hearing, Matthew +3 more
core +2 more sources