Results 31 to 40 of about 72,699 (283)

Public Transcriptomic Data Meta-Analysis Demonstrates TAAR6 Expression in the Mental Disorder-Related Brain Areas in Human and Mouse Brain

Biomolecules, 2022
G protein-coupled trace amine-associated receptors (TAAR) recognize different classes of amine compounds, including trace amines or other exogenous and endogenous molecules.
Anastasia N. Vaganova, Nataliia V. Katolikova, Ramilya Z. Murtazina, Savelii R. Kuvarzin, Raul R. Gainetdinov   +4 more
doaj   +1 more source

The pedunculopontine tegmental nucleus and the nucleus basalis magnocellularis : do both have a role in sustained attention? [PDF]

, 2008
It is well established that nucleus basalis magnocellularis (NbM) lesions impair performance on tests of sustained attention. Previous work from this laboratory has also demonstrated that pedunculopontine tegmental nucleus (PPTg) lesioned rats make more ...
Mary P Latimer, Winn, Philip, Latimer, Mary P, Winn Philip, Philip Winn, Rostron, Claire L, Farquhar, Morag J, Rostron Claire L, Claire L Rostron, Latimer, Mary P., Morag J Farquhar, Latimer Mary P, Rostron, Claire L., Farquhar Morag J, Farquhar, Morag J.   +14 more
core   +1 more source

Accumbal-thalamic connectivity and associated glutamate alterations in human cocaine craving: A state-dependent rs-fMRI and 1H-MRS study

NeuroImage: Clinical, 2023
Craving is a core symptom of cocaine use disorder and a major factor for relapse risk. To date, there is no pharmacological therapy to treat this disease or at least to alleviate cocaine craving as a core symptom.
Etna J.E. Engeli, Andrea G. Russo, Sara Ponticorvo, Niklaus Zoelch, Andreas Hock, Lea M. Hulka, Matthias Kirschner, Katrin H. Preller, Erich Seifritz, Boris B. Quednow, Fabrizio Esposito, Marcus Herdener   +11 more
doaj   +1 more source

Counteracting incentive sensitization in severe alcohol dependence using deep brain stimulation of the nucleus accumbens: clinical and basic science aspects

Frontiers in Human Neuroscience, 2009
The ventral striatum / nucleus accumbens has been implicated in the craving for drugs and alcohol which is a major reason for relapse of addicted people. Craving might be induced by drug-related cues.
Hans-Jochen Heinze, Hans-Jochen Heinze, Marcus Heldmann, Marcus Heldmann, Jürgen Voges, Jürgen Voges, Hermann Hinrichs, Josep Marco-Pallares, Jens-Max Hopf, Jens-Max Hopf, Ulf Müller, Imke Galazky, Volker Sturm, Bernhard Bogerts, Thomas F Münte   +14 more
doaj   +1 more source

Sex differences in pre- and post-synaptic glutamate signaling in the nucleus accumbens core

Biology of Sex Differences, 2023
Background Glutamate signaling within the nucleus accumbens underlies motivated behavior and is involved in psychiatric disease. Although behavioral sex differences in these processes are well-established, the neural mechanisms driving these differences ...
Melissa C. Knouse, Andre U. Deutschmann, Miroslav N. Nenov, Mathieu E. Wimmer, Lisa A. Briand   +4 more
doaj   +1 more source

FDG‐PET Associations With Disease Severity and Outcomes in NMDA‐Receptor IgG Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Patients with N‐methyl‐D‐aspartate (NMDA) receptor‐immunoglobulin G (IgG) autoimmune encephalitis (NMDAR‐IgG AE) demonstrate occipital lobe hypometabolism on baseline brain fluorodeoxyglucose‐positron emission tomography (bFDG‐PET).
Jonathan K. Lee, Jeffrey Lambe, Scott Johnson, Akua Abrah, Jennifer Bullen, Jeffrey A. Cohen, Tatchaporn Ongphichetmetha, Amy Kunchok   +7 more
wiley   +1 more source

Obesity is associated with a distinct brain-gut microbiome signature that connects Prevotella and Bacteroides to the brain’s reward center

Gut Microbes, 2022
The prevalence of obesity has risen to its highest values over the last two decades. While many studies have either shown brain or microbiome connections to obesity, few have attempted to analyze the brain-gut-microbiome relationship in a large cohort ...
Tien S. Dong, Michelle Guan, Emeran A. Mayer, Jean Stains, Cathy Liu, Priten Vora, Jonathan P. Jacobs, Venu Lagishetty, Lin Chang, Robert L. Barry, Arpana Gupta   +10 more
doaj   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Repeated methamphetamine treatment increases spine density in the nucleus accumbens of serotonin transporter knockout mice

Neuropsychopharmacology Reports, 2019
Aim Repeated psychostimulant drug treatment, including methamphetamine, in rodents readily produces behavioral sensitization, which reflects altered brain function caused by repeated drug exposure.
Yoshiyuki Kasahara, Yasufumi Sakakibara, Takashi Hiratsuka, Yuki Moriya, Klaus‐Peter Lesch, F. Scott Hall, George R. Uhl, Ichiro Sora   +7 more
doaj   +1 more source

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source