Results 21 to 30 of about 27,540 (239)
Mesolimbic dopamine release conveys causal associations [PDF]
, 2022 Learning to predict rewards based on environmental cues is essential for survival. It is believed that animals learn to predict rewards by updating predictions whenever the outcome deviates from expectations, and that such reward prediction errors (RPEs)
Burke, Dennis A +8 more
core +1 more source
Mesolimbic dopamine signals the value of work [PDF]
Nature Neuroscience, 2015 Dopamine cell firing can encode errors in reward prediction, providing a learning signal to guide future behavior. Yet dopamine is also a key modulator of motivation, invigorating current behavior. Existing theories propose that fast (phasic) dopamine fluctuations support learning, whereas much slower (tonic) dopamine changes are involved in motivation.
Arif A Hamid +8 more
openaire +3 more sources
The Mysterious Motivational Functions of Mesolimbic Dopamine [PDF]
Neuron, 2012 Nucleus accumbens dopamine is known to play a role in motivational processes, and dysfunctions of mesolimbic dopamine may contribute to motivational symptoms of depression and other disorders, as well as features of substance abuse. Although it has become traditional to label dopamine neurons as "reward" neurons, this is an overgeneralization, and it ...
Salamone, John, Correa, Merce
openaire +3 more sources
The involvement of mesolimbic dopamine system in cotinine self-administration in rats [PDF]
, 2022 Cotinine is the major metabolite of nicotine and has recently been shown to be self-administered intravenously by rats. However, mechanisms underlying cotinine self-administration remained unknown.
McBride, William J. +7 more
core +1 more source
Expression of Dopamine-Related Genes in Four Human Brain Regions
Brain Sciences, 2020 A better understanding of dopaminergic gene expression will inform future treatment options for many different neurologic and psychiatric conditions. Here, we utilized the National Institutes of Health’s Genotype-Tissue Expression project (GTEx) dataset ...
Ansley Grimes Stanfill, Xueyuan Cao
doaj +1 more source
Neurobiology of Disease, 2021 Background: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established therapeutic principle in Parkinson's disease, but the underlying mechanisms, particularly mediating non-motor actions, remain largely enigmatic.
Mareike Fauser +8 more
doaj +1 more source
Early Life Stress, Nicotinic Acetylcholine Receptors and Alcohol Use Disorders
Brain Sciences, 2015 Stress is a major driving force in alcohol use disorders (AUDs). It influences how much one consumes, craving intensity and whether an abstinent individual will return to harmful alcohol consumption. We are most vulnerable to the effects of stress during
Joan Y. Holgate, Selena E. Bartlett
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Multi‐band FMRI compromises detection of mesolimbic reward responses
NeuroImage, 2021 Recent innovations in Functional Magnetic Resonance Imaging (FMRI) have sped data collection by enabling simultaneous scans of neural activity in multiple brain locations, but have these innovations come at a cost?
Tara Srirangarajan +4 more
doaj +1 more source
Frontiers in Behavioral Neuroscience, 2016 Dopamine receptor activation in the nucleus accumbens (NAc) promotes vigorous environmentally-cued food-seeking in hungry rats. Rats fed ad libitum, however, respond to fewer food-predictive cues, particularly when the value of food reward is low.
Saleem M. Nicola +3 more
doaj +1 more source
The habenula governs the attribution of incentive salience to reward predictive cues.
Frontiers in Human Neuroscience, 2013 The attribution of incentive salience to reward associated cues is critical for motivation and the pursuit of rewards. Disruptions in the integrity of the neural systems controlling these processes can lead to avolition and anhedonia, symptoms that cross
Carey L. Danna +2 more
doaj +1 more source