Results 91 to 100 of about 34,623 (230)

INTRA-VTA INJECTIONS OF THE MU-OPIOID ANTAGONIST CTOP ENHANCE LOCOMOTOR-ACTIVITY

, 1995
In this paper we report on the effects of microinjections of the mu-opioid antagonist CTOP (D-Pen-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2) into the ventral tegmental area (VTA) on activity and ingestive behavior in the rat. Intra-VTA CTOP (0.015, 0.15, and 1.5
LEONE P, STEWART J., BADIANI, Aldo
core   +1 more source

Lateral hypothalamic glutamatergic inputs to VTA glutamatergic neurons mediate prioritization of innate defensive behavior over feeding

Nature Communications
The lateral hypothalamus (LH) is involved in feeding behavior and defense responses by interacting with different brain structures, including the Ventral Tegmental Area (VTA). Emerging evidence indicates that LH-glutamatergic neurons infrequently synapse
M. Flavia Barbano, Shiliang Zhang, Emma Chen, Orlando Espinoza, Uzma Mohammad, Yocasta Alvarez-Bagnarol, Bing Liu, Suyun Hahn, Marisela Morales   +8 more
doaj   +1 more source

Evaluation of the Adequate Radiopacity of Cavity Lining/Base and Core Build‐Up Light Cured Composite Resins

Australian Dental Journal, EarlyView.
ABSTRACT Background This study aimed to compare the radiopacity of composite resins (CR) used as lining, base, and core‐build up materials with enamel and dentine and evaluate their compliance with ISO 4049. Methods Specimens of 1, 2, and 3 mm thicknesses; (n = 6) were fabricated from 13 low‐viscosity and 10 regular‐viscosity CRs.
Carolina Alves Andrade, Isabela de Souza Silva, Letícia Passarelli Petris, Savio José Cardoso Bezerra, Cláudio Costa, Maria Angela Pita Sobral   +5 more
wiley   +1 more source

Amylin analogues as a novel perspective in anti‐obesity therapy

British Journal of Pharmacology, EarlyView.
Abstract Public health systems face a major challenge because of the worldwide obesity epidemic. The number of obese individuals has increased dramatically and, even in Switzerland which may be considered a relatively “lean” country, the numbers are alarmingly high and have reached almost 50% of the adult population.
Thomas A. Lutz
wiley   +1 more source

Gut microbiota as a novel therapeutic target for eating disorders and obesity

British Journal of Pharmacology, EarlyView.
The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė, Victor Mathis, Emmanuel Darcq, Aurelijus Burokas, Elena Martín‐García, Rafael Maldonado   +5 more
wiley   +1 more source

Locations of recorded VTA GABA neurons.

, 2012
Sample includes neurons throughout the VTA. Schematic diagrams of ventral, middle, and dorsal horizontal slices containing the VTA. (R: rostral; C: caudal; M: medial; L: lateral).
Brian Toy (148271), Elyssa B. Margolis (148265), Patricia Himmels (148277), Howard L. Fields (148283), Marisela Morales (148280)   +4 more
core   +1 more source

Dorsal Raphe Dual Serotonin-Glutamate Neurons Drive Reward by Establishing Excitatory Synapses on VTA Mesoaccumbens Dopamine Neurons

Cell Reports, 2019
Summary: Dorsal raphe (DR) serotonin neurons provide a major input to the ventral tegmental area (VTA). Here, we show that DR serotonin transporter (SERT) neurons establish both asymmetric and symmetric synapses on VTA dopamine neurons, but most of these
Hui-Ling Wang, Shiliang Zhang, Jia Qi, Huikun Wang, Roger Cachope, Carlos A. Mejias-Aponte, Jorge A. Gomez, Gabriel E. Mateo-Semidey, Gerard M.J. Beaudoin, Carlos A. Paladini, Joseph F. Cheer, Marisela Morales   +11 more
doaj   +1 more source

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

British Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral, Nicholas Monaco, Daniel I. Brierley, Monica Imbernon   +3 more
wiley   +1 more source

Dopamine in Glutamate VTA colocalization is differentially implicated in reward and fear behaviors. [PDF]

Ventral tegmental area (VTA) dopamine (DA) and glutamate (GLU) neuronal activity have been implicated in a variety of behaviors, including positive reinforcement, aversion, motivation, and motor control. Recent advances in neuroscience have shed light on
Alas, Daniel
core   +4 more sources

The ongoing oleoylethanolamide story: Therapeutic implications in the control of obesity and its comorbidities

British Journal of Pharmacology, EarlyView.
The global burden of obesity continues to rise, demanding effective pharmacological strategies for individuals in whom prevention alone is insufficient. Recent incretin‐based and multi‐agonist therapies have delivered unprecedented weight loss, demonstrating that the simultaneous modulation of multiple metabolic pathways can optimize body weight ...
Marzia Friuli, Alessia Campagna, Barbara Eramo, Christian Sepe, Annarita Zuena, Silvana Gaetani, Adele Romano   +6 more
wiley   +1 more source