Results 11 to 20 of about 34,623 (230)

Periaqueductal efferents to dopamine and GABA neurons of the VTA. [PDF]

PLoS ONE, 2018
Neurons in the periaqueductal gray (PAG) modulate threat responses and nociception. Activity in the ventral tegmental area (VTA) on the other hand can cause reinforcement and aversion.
Niels R Ntamati, Meaghan Creed, Ridouane Achargui, Christian Lüscher   +3 more
doaj   +7 more sources

The Role of Dopaminergic VTA Neurons in General Anesthesia. [PDF]

PLoS ONE, 2015
Recent studies have demonstrated that the central dopaminergic system is implicated in the mechanism underlying general anesthesia. Here, we investigated whether dopaminergic ventral tegmental area (VTA) neurons participate in general anesthesia ...
Xuelong Zhou, Yin Wang, Chenjing Zhang, Min Wang, Mei Zhang, LiNa Yu, Min Yan   +6 more
doaj   +5 more sources

Nicotinic Cholinergic Receptors in VTA Glutamate Neurons Modulate Excitatory Transmission

Cell Reports, 2018
Summary: Ventral tegmental area (VTA) glutamate neurons are important components of reward circuitry, but whether they are subject to cholinergic modulation is unknown.
Yijin Yan, Can Peng, Matthew C. Arvin, Xiao-Tao Jin, Veronica J. Kim, Matthew D. Ramsey, Yong Wang, Sambashiva Banala, David L. Wokosin, J. Michael McIntosh, Luke D. Lavis, Ryan M. Drenan   +11 more
doaj   +3 more sources

Noradrenergic signaling in the VTA modulates cocaine craving

Addiction Biology, 2017
Exposure to drug-associated cues evokes drug-seeking behavior and is regarded as a major cause of relapse. Conditional stimulus upregulates noradrenaline (NA) system activity, but the drug-seeking behavior depends particularly on phasic dopamine ...
Wojciech Barnaba Solecki, Przewłocki, Ryszard, Szklarczyk-Smolana, Klaudia, Kamil Pradel, Kwiatkowska, Krystyna, Pradel, Kamil, Krystyna Kwiatkowska, Solecki, Wojciech, Klaudia Szklarczyk, Grzegorz Dobrzański, Dobrzański, Grzegorz, Ryszard Przewłocki   +11 more
core   +4 more sources

Untangling the multifaceted VTA responses to stress

Trends in Neurosciences
Stress has profound impacts on the ventral tegmental area (VTA). However, the complex and opposing effects of stress on the VTA have limited our ability to reach a clear understanding of how adaptation of the VTA can drive behavior following stress.
Polter, Abigail M, Harris, Alexander Z, Skupio, Urszula   +2 more
core   +3 more sources

Peripheral nerve injury-induced alterations in VTA neuron firing properties

Molecular Brain, 2019
The ventral tegmental area (VTA) is one of the main brain regions harboring dopaminergic (DA) neurons, and plays important roles in reinforcement and motivation.
Shuo Huang, Stephanie L. Borgland, Gerald W. Zamponi   +2 more
doaj   +2 more sources

Hederagenin Attenuates Morphine Addiction via GABAA1-Mediated Modulation of Ca² ⁺-CaMK-CREB Signaling in Ventral Tegmental Dopaminergic Neurons. [PDF]

Adv Sci (Weinh)
Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Jiang H, Zhou Z, Xue N, Deng J, Zhou Y, Lv X, Wang Y, Zhang Y, Pan H, Xu G, Tao Y, Li M, Cui X, Ma H, Wang Q, Lu Z.   +15 more
europepmc   +2 more sources

A Critical Time Window of Neocortex Modulation for Remote Fear Memory in Rats and Humans. [PDF]

Adv Sci (Weinh)
This study identifies a delayed consolidation window around 18 h after fear learning in the mPFC essential for remote fear memory. VTA dopaminergic input during this window sustains remote memory in rats, while non‐invasive stimulation of homologous human mPFC at the corresponding time selectively weakens remote but not recent fear memory, revealing a ...
Cao L, Zhang YX, Liu XX, Li ZH, Lu TS, Deng JH, Zhang W, Li P, Lin X, Feng SF, Li TT, Meng SQ, Tang XD, Jia TY, Robbins TW, Shi J, Han Y, Xue YX, Lu L, Yuan K.   +19 more
europepmc   +2 more sources

Nucleus Accumbens and Ventral Tegmental Area Functional Connectivity as a Marker of Reward Sensitivity in Infancy. [PDF]

Dev Sci
ABSTRACT Early functional connectivity within the brain's reward circuitry may provide insight into the developmental origins of individual differences in pleasure and motivation. This study examined resting‐state functional connectivity between two key reward‐related regions, the nucleus accumbens (NAc) and ventral tegmental area (VTA), in 94 one ...
Hare MM, Niu Y, Zeanah CH, Humphreys KL.
europepmc   +2 more sources

Manipulating the CeA-VTA-ACC/OFC projections.

, 2023
(A) Quantification of CeA projections to VTA neurons activated by social interaction (n = 3). (B) The timeline of the experiments. (C) Chemogenetic inhibition schematic. (D) Schematic of the experiment.
Michał Kiełbiński (17483601), Alicja Puścian (575624), Karolina Ziegart-Sadowska (17483595), Kinga Nazaruk (17483598), Ksenia Meyza (17483592), Adam Hamed (647863), Ewelina Knapska (605627), Wojciech Solecki (48211), Karolina Rojek-Sito (13197192)   +8 more
core   +1 more source