Results 31 to 40 of about 194,049 (307)

CIB1 protects against MPTP-induced neurotoxicity through inhibiting ASK1. [PDF]

, 2017
Calcium and integrin binding protein 1 (CIB1) is a calcium-binding protein that was initially identified as a binding partner of platelet integrin αIIb. Although CIB1 has been shown to interact with multiple proteins, its biological function in the brain
Choi, Eui-Ju, Kang, Seongman, Kim, Yeonsil, Kim, Young Mok, Naik, Ulhas P., Parise, Leslie V., Sun, Woong, Yang, Hyun-Suk, Yoon, Kyoung Wan   +8 more
core   +4 more sources

Circadian Rhythm Abnormalities in Parkinson's Disease from Humans to Flies and Back [PDF]

, 2018
Clinical and research studies have suggested a link between Parkinson\u2019s disease (PD) and alterations in the circadian clock. Drosophila melanogaster may represent a useful model to study the relationship between the circadian clock and PD.
Bisaglia, Marco, De Lazzari, Federica, Sandrelli, Federica, Zordan, Mauro Agostino   +3 more
core   +1 more source

Treg Cells Protect Dopaminergic Neurons against MPP+ Neurotoxicity via CD47-SIRPA Interaction

Cellular Physiology and Biochemistry, 2017
Background/Aims: Regulatory T (Treg) cells have been associated with neuroprotection by inhibiting microglial activation in animal models of Parkinson's disease (PD), a progressive neurodegenerative disease characterized by dopaminergic neuronal loss in ...
Yan Huang, Zhan Liu, Bei-Bei Cao, Yi-Hua Qiu, Yu-Ping Peng   +4 more
doaj   +1 more source

Reduced ER-mitochondrial contact sites and mitochondrial Ca2+ flux in PRKN-mutant patient tyrosine hydroxylase reporter iPSC lines

Frontiers in Cell and Developmental Biology, 2023
Endoplasmic reticulum-mitochondrial contact sites (ERMCS) play an important role in mitochondrial dynamics, calcium signaling, and autophagy. Disruption of the ERMCS has been linked to several neurodegenerative diseases, including Alzheimer’s disease (AD)
Mutsumi Yokota, Yutaro Yoshino, Mitsuko Hosoi, Ryota Hashimoto, Soichiro Kakuta, Takahiro Shiga, Kei-Ichi Ishikawa, Kei-Ichi Ishikawa, Hideyuki Okano, Nobutaka Hattori, Nobutaka Hattori, Wado Akamatsu, Masato Koike   +12 more
doaj   +1 more source

Locomotor hyperactivity in 14-3-3Zeta KO mice is associated with dopamine transporter dysfunction [PDF]

, 2013
Dopamine (DA) neurotransmission requires a complex series of enzymatic reactions that are tightly linked to catecholamine exocytosis and receptor interactions on pre- and postsynaptic neurons.
A Abi-Dargham, A Aitken, A Breier, A Vina-Vilaseca, AA Williams, AH Wong, B Giros, B Giros, BL Summers, BT Baune, C Itagaki, CA Tamminga, D Berg, D Sulzer, DL Levy, FA Middleton, H Fu, H Jaaro-Peled, H Khoshbouei, H Koike, HC Baxter, J Sun, J Wang, JA English, JA English, JA Lieberman, JA Lieberman, JH Son, JM van Rossum, K Toska, K Toyo-oka, K Toyo-Oka, KL Holton, M Laruelle, M Laruelle, M Miranda, M Rosner, M van den Buuse, M van den Buuse, MS Samuel, O Halskau Jr., P Coyle, PC Hart, PS Cheah, S Leucht, S Sivagnanasundaram, S Sivagnanasundaram, SG Amara, SR Jones, T Ichimura, T Ichimura, WC Drevets, WT Carpenter, Y Jia   +53 more
core   +2 more sources

Punishment Prediction by Dopaminergic Neurons in Drosophila [PDF]

Current Biology, 2005
The temporal pairing of a neutral stimulus with a reinforcer (reward or punishment) can lead to classical conditioning, a simple form of learning in which the animal assigns a value (positive or negative) to the formerly neutral stimulus. Olfactory classical conditioning in Drosophila is a prime model for the analysis of the molecular and neuronal ...
Riemensperger, Thomas, Völler, Thomas, Stock, Patrick, Buchner, Erich, Fiala, André   +4 more
openaire   +2 more sources

Discovery of nigral dopaminergic neurogenesis in adult mice

Neural Regeneration Research, 2016
Parkinson′s disease is characterized by the loss of dopaminergic neurons in the substantia nigra. As a result, intensive efforts have focused upon mechanisms that facilitate the death of mature dopaminergic neurons. Unfortunately, these efforts have been
Brad E Morrison
doaj   +1 more source

Generation and characterization of a mouse line for monitoring translation in dopaminergic neurons [PDF]

, 2017
We developed a mouse line targeting midbrain dopamine neurons for Translating Ribosome Affinity Purification(TRAP). Here, we briefly report on the basic characterization of this mouse line including confirmation of expression of the transgene in midbrain
Dougherty, Joseph D
core   +2 more sources

Dopaminergic Neurons Intrinsic to the Primate Striatum [PDF]

The Journal of Neuroscience, 1997
Intrinsic, striatal tyrosine hydroxylase-immunoreactive (TH-i) cells have received little consideration. In this study we have characterized these neurons and their regulatory response to nigrostriatal dopaminergic deafferentation. TH-i cells were observed in the striatum of both control and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated ...
R, Betarbet, R, Turner, V, Chockkan, M R, DeLong, K A, Allers, J, Walters, A I, Levey, J T, Greenamyre   +7 more
openaire   +2 more sources

Acquisition of the Midbrain Dopaminergic Neuronal Identity [PDF]

International Journal of Molecular Sciences, 2020
The mesodiencephalic dopaminergic (mdDA) group of neurons comprises molecularly distinct subgroups, of which the substantia nigra (SN) and ventral tegmental area (VTA) are the best known, due to the selective degeneration of the SN during Parkinson’s disease.
Simone Mesman, Marten P. Smidt
openaire   +3 more sources