Results 31 to 40 of about 598,888 (295)

Sex-specific disruption of murine midbrain astrocytic and dopaminergic developmental trajectories following antenatal GC treatment [PDF]

, 2015
The mammalian midbrain dopaminergic systems arising in the substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) are critical for coping behaviours and are implicated in neuropsychiatric disorders where early life challenges comprise ...
Pienaar, Ilse, Gillies, Glenda, McArthur, S, Gillies, G.E., Siddiqi, Sindhu, Siddiqi, SM, Sindhu M. Siddiqi, Siddiqi, S, McArthur, Simon, Glenda E. Gillies, Mazhar-Siddiqi, S., McArthur, S., Simon McArthur, Ilse S. Pienaar, Siddiqi, S.M., Pienaar, IS, Gillies, GE, Pienaar, I.S., Pienaar, I   +18 more
core   +2 more sources

Hederagenin Attenuates Morphine Addiction via GABAA1-Mediated Modulation of Ca² ⁺-CaMK-CREB Signaling in Ventral Tegmental Dopaminergic Neurons. [PDF]

Adv Sci (Weinh)
Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Jiang H, Zhou Z, Xue N, Deng J, Zhou Y, Lv X, Wang Y, Zhang Y, Pan H, Xu G, Tao Y, Li M, Cui X, Ma H, Wang Q, Lu Z.   +15 more
europepmc   +2 more sources

An Intrinsic Neuronal Oscillator Underlies Dopaminergic Neuron Bursting [PDF]

The Journal of Neuroscience, 2009
Dopaminergic neurons of the ventral midbrain fire high-frequency bursts when animals are presented with unexpected rewards, or stimuli that predict reward. To identify the afferents that can initiate bursting and establish therapeutic strategies for diseases affected by altered bursting, a mechanistic understanding of bursting is ...
Christopher A, Deister, Mark A, Teagarden, Charles J, Wilson, Carlos A, Paladini   +3 more
openaire   +2 more sources

Reduced ER-mitochondrial contact sites and mitochondrial Ca2+ flux in PRKN-mutant patient tyrosine hydroxylase reporter iPSC lines

Frontiers in Cell and Developmental Biology, 2023
Endoplasmic reticulum-mitochondrial contact sites (ERMCS) play an important role in mitochondrial dynamics, calcium signaling, and autophagy. Disruption of the ERMCS has been linked to several neurodegenerative diseases, including Alzheimer’s disease (AD)
Mutsumi Yokota, Yutaro Yoshino, Mitsuko Hosoi, Ryota Hashimoto, Soichiro Kakuta, Takahiro Shiga, Kei-Ichi Ishikawa, Kei-Ichi Ishikawa, Hideyuki Okano, Nobutaka Hattori, Nobutaka Hattori, Wado Akamatsu, Masato Koike   +12 more
doaj   +1 more source

Treg Cells Protect Dopaminergic Neurons against MPP+ Neurotoxicity via CD47-SIRPA Interaction

Cellular Physiology and Biochemistry, 2017
Background/Aims: Regulatory T (Treg) cells have been associated with neuroprotection by inhibiting microglial activation in animal models of Parkinson's disease (PD), a progressive neurodegenerative disease characterized by dopaminergic neuronal loss in ...
Yan Huang, Zhan Liu, Bei-Bei Cao, Yi-Hua Qiu, Yu-Ping Peng   +4 more
doaj   +1 more source

Dopaminergic Neurons Intrinsic to the Primate Striatum [PDF]

The Journal of Neuroscience, 1997
Intrinsic, striatal tyrosine hydroxylase-immunoreactive (TH-i) cells have received little consideration. In this study we have characterized these neurons and their regulatory response to nigrostriatal dopaminergic deafferentation. TH-i cells were observed in the striatum of both control and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated ...
R, Betarbet, R, Turner, V, Chockkan, M R, DeLong, K A, Allers, J, Walters, A I, Levey, J T, Greenamyre   +7 more
openaire   +2 more sources

Pharmacogenetic stimulation of cholinergic pedunculopontine neurons reverses motor deficits in a rat model of Parkinson's disease [PDF]

, 2015
Background Patients with advanced Parkinson's disease (PD) often present with axial symptoms, including postural- and gait difficulties that respond poorly to dopaminergic agents.
Pienaar, Ilse, De Paola, V, Gretenkord, Sabine, David Dexter (3572210), Sabine Gretenkord, Withers, Dominic, Ilse Pienaar (4504357), Dominic Withers (3572216), Gartside, Sarah, De Paola, Vincenzo, Puneet Sharma, Ilse S. Pienaar, Puneet Sharma (3572222), Sharma, Puneet, Dominic Withers, Sabine Gretenkord (3572213), David T. Dexter, Vincenzo De Paola, Joanna L. Elson, Ilse Pienaar (3572219), Joanna L Elson (16036517), Sarah Gartside (3572225), Dexter, David, Elson, Joanna, Sarah E. Gartside, Joanna Elson (271089), Vincenzo De Paola (275215), Sarah E Gartside (16264538), David T Dexter (9237410)   +28 more
core   +1 more source

Discovery of nigral dopaminergic neurogenesis in adult mice

Neural Regeneration Research, 2016
Parkinson′s disease is characterized by the loss of dopaminergic neurons in the substantia nigra. As a result, intensive efforts have focused upon mechanisms that facilitate the death of mature dopaminergic neurons. Unfortunately, these efforts have been
Brad E Morrison
doaj   +1 more source

Immediate early gene expression in the mesopontine tegmentum and midbrain after acute or chronic nicotine administration [PDF]

, 2008
The reinforcing properties of nicotine depend partly on cholinergic projections from the pedunculopontine tegmental (PPTg) and laterodorsal tegmental (LDTg) nuclei to midbrain dopamine neurons in the ventral tegmental area (VTA) and substantia nigra pars
Porter, Ailsa
core   +2 more sources

Dopaminergic neurodegeneration in the substantia nigra is associated with olfactory dysfunction in mice models of Parkinson’s disease

Cell Death Discovery, 2023
Olfactory dysfunction represents a prodromal stage in Parkinson’s disease (PD). However, the mechanisms underlying hyposmia are not specified yet.
Yu Yuan, Xizhen Ma, Xiaoqing Mi, Le Qu, Meiyu Liang, Mengyu Li, Youcui Wang, Ning Song, Junxia Xie   +8 more
doaj   +1 more source