Results 31 to 40 of about 122,423 (305)

Punishment Prediction by Dopaminergic Neurons in Drosophila [PDF]

Current Biology, 2005
The temporal pairing of a neutral stimulus with a reinforcer (reward or punishment) can lead to classical conditioning, a simple form of learning in which the animal assigns a value (positive or negative) to the formerly neutral stimulus. Olfactory classical conditioning in Drosophila is a prime model for the analysis of the molecular and neuronal ...
Riemensperger, Thomas, Völler, Thomas, Stock, Patrick, Buchner, Erich, Fiala, André   +4 more
openaire   +2 more sources

SEX-DEPENDENT DIVERSITY IN VENTRAL TEGMENTAL DOPAMINERGIC NEURONS AND DEVELOPMENTAL PROGRAMING: A MOLECULAR, CELLULAR AND BEHAVIORAL ANALYSIS [PDF]

, 2014
The knowledge that diverse populations of dopaminergic neurons within the ventral tegmental area (VTA) can be distinguished in terms of their molecular, electrophysiological and functional properties, as well as their differential projections to cortical
Gillies, G.E., Virdee, K, Mcarthur, S, Virdee, K., Dalley, JW, Dalley, J.W., McArthur, S., Gillies, GE   +7 more
core   +1 more source

Treg Cells Protect Dopaminergic Neurons against MPP+ Neurotoxicity via CD47-SIRPA Interaction

Cellular Physiology and Biochemistry, 2017
Background/Aims: Regulatory T (Treg) cells have been associated with neuroprotection by inhibiting microglial activation in animal models of Parkinson's disease (PD), a progressive neurodegenerative disease characterized by dopaminergic neuronal loss in ...
Yan Huang, Zhan Liu, Bei-Bei Cao, Yi-Hua Qiu, Yu-Ping Peng   +4 more
doaj   +1 more source

Reduced ER-mitochondrial contact sites and mitochondrial Ca2+ flux in PRKN-mutant patient tyrosine hydroxylase reporter iPSC lines

Frontiers in Cell and Developmental Biology, 2023
Endoplasmic reticulum-mitochondrial contact sites (ERMCS) play an important role in mitochondrial dynamics, calcium signaling, and autophagy. Disruption of the ERMCS has been linked to several neurodegenerative diseases, including Alzheimer’s disease (AD)
Mutsumi Yokota, Yutaro Yoshino, Mitsuko Hosoi, Ryota Hashimoto, Soichiro Kakuta, Takahiro Shiga, Kei-Ichi Ishikawa, Kei-Ichi Ishikawa, Hideyuki Okano, Nobutaka Hattori, Nobutaka Hattori, Wado Akamatsu, Masato Koike   +12 more
doaj   +1 more source

Discovery of nigral dopaminergic neurogenesis in adult mice

Neural Regeneration Research, 2016
Parkinson′s disease is characterized by the loss of dopaminergic neurons in the substantia nigra. As a result, intensive efforts have focused upon mechanisms that facilitate the death of mature dopaminergic neurons. Unfortunately, these efforts have been
Brad E Morrison
doaj   +1 more source

Dopaminergic Neurons Intrinsic to the Primate Striatum [PDF]

The Journal of Neuroscience, 1997
Intrinsic, striatal tyrosine hydroxylase-immunoreactive (TH-i) cells have received little consideration. In this study we have characterized these neurons and their regulatory response to nigrostriatal dopaminergic deafferentation. TH-i cells were observed in the striatum of both control and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated ...
R, Betarbet, R, Turner, V, Chockkan, M R, DeLong, K A, Allers, J, Walters, A I, Levey, J T, Greenamyre   +7 more
openaire   +2 more sources

Acquisition of the Midbrain Dopaminergic Neuronal Identity [PDF]

International Journal of Molecular Sciences, 2020
The mesodiencephalic dopaminergic (mdDA) group of neurons comprises molecularly distinct subgroups, of which the substantia nigra (SN) and ventral tegmental area (VTA) are the best known, due to the selective degeneration of the SN during Parkinson’s disease.
Simone Mesman, Marten P. Smidt
openaire   +3 more sources

A functional characterisation of retrorubral field dopaminergic neurons

, 2021
Characterising the function of the brain in health is critical if the changes that occur during disease states are to be fully understood. This is particularly true of the midbrain dopaminergic system, which is compromised in disorders such as Parkinson ...
Bryden, Luke Alexander
core   +2 more sources

Dopaminergic neurodegeneration in the substantia nigra is associated with olfactory dysfunction in mice models of Parkinson’s disease

Cell Death Discovery, 2023
Olfactory dysfunction represents a prodromal stage in Parkinson’s disease (PD). However, the mechanisms underlying hyposmia are not specified yet.
Yu Yuan, Xizhen Ma, Xiaoqing Mi, Le Qu, Meiyu Liang, Mengyu Li, Youcui Wang, Ning Song, Junxia Xie   +8 more
doaj   +1 more source

How to make a midbrain dopaminergic neuron [PDF]

Development, 2015
ABSTRACT Midbrain dopaminergic (mDA) neuron development has been an intense area of research during recent years. This is due in part to a growing interest in regenerative medicine and the hope that treatment for diseases affecting mDA neurons, such as Parkinson's disease (PD), might be facilitated by a better understanding of how ...
E. Arenas, M. Denham, J. C. Villaescusa
openaire   +3 more sources