Results 21 to 30 of about 122,423 (305)
Primary Culture of Mouse Dopaminergic Neurons [PDF]
Journal of Visualized Experiments, 2014 Dopaminergic neurons represent less than 1% of the total number of neurons in the brain. This low amount of neurons regulates important brain functions such as motor control, motivation, and working memory. Nigrostriatal dopaminergic neurons selectively degenerate in Parkinson's disease (PD).
Gaven, Florence +2 more
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Cell Death and Disease, 2021 Parkinson’s disease is a common neurodegenerative disease. Cell transplantation is a promising therapeutic option for improving the survival and function of dopaminergic neurons, but the mechanisms underlying the interaction between the transplanted ...
Chengxiao Ma +6 more
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Scientific Reports, 2022 Wnt/β-catenin signaling contributes to patterning, proliferation, and differentiation throughout vertebrate neural development. Wnt/β-catenin signaling is important for mammalian midbrain dopaminergic neurogenesis, while little is known about its role in
Markus Westphal +4 more
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npj Parkinson's Disease, 2022 In addition to the well-known degeneration of midbrain dopaminergic neurons, enteric neurons can also be affected in neurodegenerative disorders such as Parkinson’s disease (PD).
Alcmène Chalazonitis +2 more
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miR-34b/c Regulates Wnt1 and Enhances Mesencephalic Dopaminergic Neuron Differentiation
Stem Cell Reports, 2018 Summary: The differentiation of dopaminergic neurons requires concerted action of morphogens and transcription factors acting in a precise and well-defined time window. Very little is known about the potential role of microRNA in these events.
Roberto De Gregorio +18 more
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Catechol-O-methyltransferase (COMT) protein expression and activity after dopaminergic and noradrenergic lesions of the rat brain. [PDF]
PLoS ONE, 2013 The occurrence of catechol-O-methyltransferase (COMT) in presynaptic neurons remains controversial. This study utilized dopaminergic and noradrenergic toxins to assess the presence of COMT in the presynaptic neurons originating from the substantia nigra,
Nadia Schendzielorz +5 more
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Neural Regeneration Research, 2021 Previous studies have shown that caveolin-1 is involved in regulating the differentiation of mesenchymal stem cells. However, its role in the differentiation of human adipose mesenchymal stem cells into dopaminergic neurons remains unclear.
Chao Han +7 more
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Integrin α5β1 expression on dopaminergic neurons is involved in dopaminergic neurite outgrowth on striatal neurons [PDF]
Scientific Reports, 2017 AbstractDuring development, dopaminergic neurons born in the substantia nigra extend their axons toward the striatum. However, the mechanisms by which the dopaminergic axons extend the striatum to innervate their targets remain unclear. We previously showed that paired-cultivation of mesencephalic cells containing dopaminergic neurons with striatal ...
Izumi, Yasuhiko +5 more
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An Intrinsic Neuronal Oscillator Underlies Dopaminergic Neuron Bursting [PDF]
The Journal of Neuroscience, 2009 Dopaminergic neurons of the ventral midbrain fire high-frequency bursts when animals are presented with unexpected rewards, or stimuli that predict reward. To identify the afferents that can initiate bursting and establish therapeutic strategies for diseases affected by altered bursting, a mechanistic understanding of bursting is ...
Christopher A, Deister +3 more
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Dichlorodiphenyltrichloroethane specifically depletes dopaminergic neurons in primary cell culture [PDF]
, 2003 Toxicity of dichlorodiphenyltrichloroethane (DDT) to dopaminergic neurons in primary cell culture was investigated in the present study. Developing neurons from the substantia nigra of neonatal rats were cultured.
Leung, KW +5 more
core +1 more source