Results 21 to 30 of about 194,049 (307)

Similarities and differences between nigral and enteric dopaminergic neurons unravel distinctive involvement in Parkinson’s disease

npj Parkinson's Disease, 2022
In addition to the well-known degeneration of midbrain dopaminergic neurons, enteric neurons can also be affected in neurodegenerative disorders such as Parkinson’s disease (PD).
Alcmène Chalazonitis, Meenakshi Rao, David Sulzer   +2 more
doaj   +1 more source

Caveolin-1 downregulation promotes the dopaminergic neuron-like differentiation of human adipose-derived mesenchymal stem cells

Neural Regeneration Research, 2021
Previous studies have shown that caveolin-1 is involved in regulating the differentiation of mesenchymal stem cells. However, its role in the differentiation of human adipose mesenchymal stem cells into dopaminergic neurons remains unclear.
Chao Han, Ya-Jun Wang, Ya-Chen Wang, Xin Guan, Liang Wang, Li-Ming Shen, Wei Zou, Jing Liu   +7 more
doaj   +1 more source

Effect of hyperthyroidism on circulating prolactin and hypothalamic expression of tyrosine hydroxylase, prolactin signaling cascade members and estrogen and progesterone receptors during late pregnancy and lactation in the rat [PDF]

, 2017
Hyperthyroidism (HyperT) compromises pregnancy and lactation, hindering suckling-induced PRL release. We studied the effect of HyperT on hypothalamic mRNA (RT-qPCR) and protein (Western blot) expression of tyrosine hydroxylase (TH), PRL receptor (PRLR ...
Jahn, Graciela Alma, Neira, Flavia Judith, Pennacchio, Gisela Erika, Soaje, Marta, Valdez, Susana Ruth   +4 more
core   +1 more source

miR-34b/c Regulates Wnt1 and Enhances Mesencephalic Dopaminergic Neuron Differentiation

Stem Cell Reports, 2018
Summary: The differentiation of dopaminergic neurons requires concerted action of morphogens and transcription factors acting in a precise and well-defined time window. Very little is known about the potential role of microRNA in these events.
Roberto De Gregorio, Salvatore Pulcrano, Claudia De Sanctis, Floriana Volpicelli, Ezia Guatteo, Lars von Oerthel, Emanuele Claudio Latagliata, Roberta Esposito, Rosa Maria Piscitelli, Carla Perrone-Capano, Valerio Costa, Dario Greco, Stefano Puglisi-Allegra, Marten P. Smidt, Umberto di Porzio, Massimiliano Caiazzo, Nicola Biagio Mercuri, Meng Li, Gian Carlo Bellenchi   +18 more
doaj   +1 more source

Catechol-O-methyltransferase (COMT) protein expression and activity after dopaminergic and noradrenergic lesions of the rat brain. [PDF]

PLoS ONE, 2013
The occurrence of catechol-O-methyltransferase (COMT) in presynaptic neurons remains controversial. This study utilized dopaminergic and noradrenergic toxins to assess the presence of COMT in the presynaptic neurons originating from the substantia nigra,
Nadia Schendzielorz, Juha-Pekka Oinas, Timo T Myöhänen, Ilkka Reenilä, Atso Raasmaja, Pekka T Männistö   +5 more
doaj   +1 more source

Integrin α5β1 expression on dopaminergic neurons is involved in dopaminergic neurite outgrowth on striatal neurons [PDF]

Scientific Reports, 2017
AbstractDuring development, dopaminergic neurons born in the substantia nigra extend their axons toward the striatum. However, the mechanisms by which the dopaminergic axons extend the striatum to innervate their targets remain unclear. We previously showed that paired-cultivation of mesencephalic cells containing dopaminergic neurons with striatal ...
Izumi, Yasuhiko, Wakita, Seiko, Kanbara, Chisato, Nakai, Toshie, Akaike, Akinori, Kume, Toshiaki   +5 more
openaire   +2 more sources

Proteomic insights into the biology of dopaminergic neurons. [PDF]

Front Mol Neurosci
Dopaminergic neurons, primarily located in the substantia nigra, hypothalamus, and ventral tegmental area of the brain, play crucial roles in motor control, reward, motivation, and cognition. Alterations in their function are associated with numerous neurological and psychiatric disorders, such as Parkinson’s disease, but also Schizophrenia, substance ...
Cavarischia-Rega C, Sharma K, Fitzgerald JC, Macek B.   +3 more
europepmc   +4 more sources

Orexinergic Input to Dopaminergic Neurons of the Human Ventral Tegmental Area [PDF]

, 2013
The mesolimbic reward pathway arising from dopaminergic (DA) neurons of the ventral tegmental area (VTA) has been strongly implicated in reward processing and drug abuse.
A Bisetti, AJ Lawrence, Alice Y. W. Chang, AR Di Sebastiano, B Boutrel, B Boutrel, B Wang, BA Baldo, Beáta Á. Borsay, C Baimel, C Peyron, CM Kotz, CS Molnar, Csilla S. Molnár, CV Dayas, D Georgescu, D Sulzer, E Hirsch, E Hrabovszky, E Hrabovszky, Erik Hrabovszky, G Aston-Jones, G Martin, GC Harris, GC Harris, J Fadel, J Xia, JA Hollander, JJ Balcita-Pedicino, K Mukai, L de Lecea, László Herczeg, M Barrot, M Narita, NM Vittoz, NM Vittoz, Péter Gergely, R Fronczek, R Sharf, R Sharf, RM Chemelli, S Deurveilher, S Srinivasan, SL Borgland, SV Mahler, T Bullmann, T Nakamura, T Sakurai, TM Korotkova, TM Korotkova, XY Lu, Y Date, Z Liposits, Zsolt Liposits   +53 more
core   +2 more sources

An Intrinsic Neuronal Oscillator Underlies Dopaminergic Neuron Bursting [PDF]

The Journal of Neuroscience, 2009
Dopaminergic neurons of the ventral midbrain fire high-frequency bursts when animals are presented with unexpected rewards, or stimuli that predict reward. To identify the afferents that can initiate bursting and establish therapeutic strategies for diseases affected by altered bursting, a mechanistic understanding of bursting is ...
Christopher A, Deister, Mark A, Teagarden, Charles J, Wilson, Carlos A, Paladini   +3 more
openaire   +2 more sources

Deficient reinforcement learning in medial frontal cortex as a model of dopamine-related motivational deficits in ADHD [PDF]

, 2013
A
Barke, Edmund, Silvetti, Massimo, Verguts, Tom, Wiersema, Roeljan   +3 more
core   +2 more sources