Results 21 to 30 of about 598,888 (295)

Efficient conversion of astrocytes to functional midbrain dopaminergic neurons using a single polycistronic vector.

PLoS ONE, 2011
Direct cellular reprogramming is a powerful new tool for regenerative medicine. In efforts to understand and treat Parkinson's Disease (PD), which is marked by the degeneration of dopaminergic neurons in the midbrain, direct reprogramming provides a ...
Russell C Addis, Fu-Chun Hsu, Rebecca L Wright, Marc A Dichter, Douglas A Coulter, John D Gearhart   +5 more
doaj   +1 more source

Wnt/β-catenin signaling promotes neurogenesis in the diencephalospinal dopaminergic system of embryonic zebrafish

Scientific Reports, 2022
Wnt/β-catenin signaling contributes to patterning, proliferation, and differentiation throughout vertebrate neural development. Wnt/β-catenin signaling is important for mammalian midbrain dopaminergic neurogenesis, while little is known about its role in
Markus Westphal, Paolo Panza, Edda Kastenhuber, Johanna Wehrle, Wolfgang Driever   +4 more
doaj   +1 more source

Tetraspanin (TSP-17) Protects Dopaminergic Neurons against 6-OHDA-Induced Neurodegeneration in C. elegans [PDF]

, 2014
Parkinson's disease (PD), the second most prevalent neurodegenerative disease after Alzheimer's disease, is linked to the gradual loss of dopaminergic neurons in the substantia nigra.
Masoudi, Neda, Neda Masoudi (541180), Masoudi Neda, Gartner Anton, Ibanez-Cruceyra, Pablo, Alexander Holmes (669499), Sarah-Lena Offenburger, Offenburger, Sarah-Lena, Anton Gartner (208255), Neda Masoudi, Alexander Holmes, Ibanez-Cruceyra Pablo, Holmes Alexander, Pablo Ibanez-Cruceyra (669497), Offenburger Sarah-Lena, Anton Gartner, Holmes, Alexander, Pablo Ibanez-Cruceyra, Sarah-Lena Offenburger (669498), Gartner, Anton   +19 more
core   +1 more source

Similarities and differences between nigral and enteric dopaminergic neurons unravel distinctive involvement in Parkinson’s disease

npj Parkinson's Disease, 2022
In addition to the well-known degeneration of midbrain dopaminergic neurons, enteric neurons can also be affected in neurodegenerative disorders such as Parkinson’s disease (PD).
Alcmène Chalazonitis, Meenakshi Rao, David Sulzer   +2 more
doaj   +1 more source

Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nuclei [PDF]

, 2011
Background: The ventral midbrain contains a diverse array of neurons, including dopaminergic neurons of the ventral tegmental area (VTA) and substantia nigra (SN) and neurons of the red nucleus (RN).
Joyner, Alexandra L., Stephen Daniel, Chanet, S., Chanet, Soline, Blaess, S., Emilie Mugniery, Sandra Blaess, Joyner, L., Daniel Stephen, Soline Chanet, Mugniery, E., Kabanova, Anna, Bodea, G., Blaess, Sandra, Derouiche, Amin, Alexandra L Joyner, Mugniery Emilie, Gabriela O Bodea, Chanet Soline, Joyner, Alexandra, Joyner Alexandra L, Bodea, Gabriela O., Mugniery, Emilie, Derouiche, A., Blaess Sandra, Stephen, D., Kabanova, A., Derouiche Amin, Bodea Gabriela O, Bodea, Gabriela, Kabanova Anna, Anna Kabanova, Stephen, Daniel, Amin Derouiche   +33 more
core   +1 more source

Caveolin-1 downregulation promotes the dopaminergic neuron-like differentiation of human adipose-derived mesenchymal stem cells

Neural Regeneration Research, 2021
Previous studies have shown that caveolin-1 is involved in regulating the differentiation of mesenchymal stem cells. However, its role in the differentiation of human adipose mesenchymal stem cells into dopaminergic neurons remains unclear.
Chao Han, Ya-Jun Wang, Ya-Chen Wang, Xin Guan, Liang Wang, Li-Ming Shen, Wei Zou, Jing Liu   +7 more
doaj   +1 more source

Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system [PDF]

, 2007
Support of ageing neurons by endogenous neurotrophic factors such as glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) may determine whether the neurons resist or succumb to neurodegeneration.
Aron, Liviu, Edgar R Kramer, Zhuang, Xiaoxi, Klein, R., Klaus Beyer, Geert M J Ramakers, Smidt, Marten P., Kramer, E., Ramakers, Geert M. J., Klein, Rüdiger, Beyer, K., Seitz, S., Marten P Smidt, Ramakers, G., Xiaoxi Zhuang, Beyer, Klaus, Zhuang, X., Liviu Aron, Sabine Seitz, Rüdiger Klein, Smidt, M., Seitz, Sabine, Kramer, Edgar R., Aron, L., Kramer Edgar R, Ramakers, Geert M. J, Smidt Marten P, Ramakers Geert M. J, Seitz Sabine, Aron Liviu, Zhuang Xiaoxi, Beyer Klaus, Klein Rüdiger   +32 more
core   +2 more sources

miR-34b/c Regulates Wnt1 and Enhances Mesencephalic Dopaminergic Neuron Differentiation

Stem Cell Reports, 2018
Summary: The differentiation of dopaminergic neurons requires concerted action of morphogens and transcription factors acting in a precise and well-defined time window. Very little is known about the potential role of microRNA in these events.
Roberto De Gregorio, Salvatore Pulcrano, Claudia De Sanctis, Floriana Volpicelli, Ezia Guatteo, Lars von Oerthel, Emanuele Claudio Latagliata, Roberta Esposito, Rosa Maria Piscitelli, Carla Perrone-Capano, Valerio Costa, Dario Greco, Stefano Puglisi-Allegra, Marten P. Smidt, Umberto di Porzio, Massimiliano Caiazzo, Nicola Biagio Mercuri, Meng Li, Gian Carlo Bellenchi   +18 more
doaj   +1 more source

Catechol-O-methyltransferase (COMT) protein expression and activity after dopaminergic and noradrenergic lesions of the rat brain. [PDF]

PLoS ONE, 2013
The occurrence of catechol-O-methyltransferase (COMT) in presynaptic neurons remains controversial. This study utilized dopaminergic and noradrenergic toxins to assess the presence of COMT in the presynaptic neurons originating from the substantia nigra,
Nadia Schendzielorz, Juha-Pekka Oinas, Timo T Myöhänen, Ilkka Reenilä, Atso Raasmaja, Pekka T Männistö   +5 more
doaj   +1 more source

A simple Hidden Markov Model for midbrain dopaminergic neurons [PDF]

, 2009
Poster presentation: Introduction Dopaminergic neurons in the midbrain show a variety of firing patterns, ranging from very regular firing pacemaker cells to bursty and irregular neurons.
Gerhard, Felipe, Roeper, Jochen, Felipe Gerhard, Schneider, Gaby, Gaby Schneider, Schiemann, Julia, Jochen Roeper, Julia Schiemann   +7 more
core   +1 more source