Results 1 to 10 of about 116,678 (153)

MIRO1 mutation leads to metabolic maladaptation resulting in Parkinson’s disease-associated dopaminergic neuron loss [PDF]

npj Systems Biology and Applications
MIRO1 is a mitochondrial outer membrane protein important for mitochondrial distribution, dynamics and bioenergetics. Over the last decade, evidence has pointed to a link between MIRO1 and Parkinson’s disease (PD) pathogenesis.
Alise Zagare, Thomas Sauter, Kyriaki Barmpa, Maria Pacheco, Rejko Krüger, Jens Christian Schwamborn, Claudia Saraiva   +6 more
doaj   +2 more sources

LncRNA-T199678 Mitigates α-Synuclein-Induced Dopaminergic Neuron Injury via miR-101-3p

Frontiers in Aging Neuroscience, 2020
Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by dopaminergic neuron death and the abnormal accumulation and aggregation of α-synuclein (α-Syn) in the substantia nigra (SN). Although the abnormal accumulation
Lu-Lu Bu, Lu-Lu Bu, Ying-Yu Xie, Ying-Yu Xie, Dan-Yu Lin, Ying Chen, Ying Chen, Xiu-Na Jing, Xiu-Na Jing, Yan-Ran Liang, Yan-Ran Liang, Su-Dan Peng, Su-Dan Peng, Kai-Xun Huang, En-Xiang Tao, En-Xiang Tao   +15 more
exaly   +3 more sources

Neurogenic differentiation of dental pulp stem cells to neuron-like cells in dopaminergic and motor neuronal inductive media

Journal of the Formosan Medical Association, 2014
Dental pulp stem cells (DPSCs) have been proposed as a promising source of stem cells in nerve regeneration due to their close embryonic origin and ease of harvest.
Hao-Hueng Chang, Chun-Pin Lin
exaly   +3 more sources

The Parkinson’s disease-associated LRRK2-G2019S variant restricts serine metabolism, leading to microglial inflammation and dopaminergic neuron degeneration [PDF]

Journal of Neuroinflammation
A growing body of evidence implicates inflammation as a key hallmark in the pathophysiology of Parkinson’s disease (PD), with microglia playing a central role in mediating neuroinflammatory signaling in the brain.
Henry Kurniawan, Sarah L. Nickels, Alise Zagare, Elisa Zuccoli, Isabel Rosety, Gemma Gomez-Giro, Enrico Glaab, Jens C. Schwamborn   +7 more
doaj   +2 more sources

Sustained chemogenetic activation of locus coeruleus norepinephrine neurons promotes dopaminergic neuron survival in synucleinopathy

PLoS ONE, 2022
Dopaminergic neuron degeneration in the midbrain plays a pivotal role in motor symptoms associated with Parkinson’s disease. However, non-motor symptoms of Parkinson’s disease and post-mortem histopathology confirm dysfunction in other brain areas ...
Predrag Jovanovic, Yidan Wang, Jean-Philippe Vit, Edward Novinbakht, Nancy Morones, Elliot Hogg, Michele Tagliati, Celine E. Riera   +7 more
doaj   +2 more sources

The inflammatory injury in the striatal microglia-dopaminergic-neuron crosstalk involved in Tourette syndrome development [PDF]

Frontiers in Immunology, 2023
Xiumei Liu
exaly   +2 more sources

The Crucial Roles of Pitx3 in Midbrain Dopaminergic Neuron Development and Parkinson’s Disease-Associated Neurodegeneration [PDF]

International Journal of Molecular Sciences, 2023
Guangdong Liu, Huaibin Cai, Weidong Le   +2 more
exaly   +2 more sources

Identification of signaling pathways modifying human dopaminergic neuron development using a pluripotent stem cell-based high-throughput screening automated system: purinergic pathways as a proof-of-principle

Frontiers in Pharmacology, 2023
Introduction: Alteration in the development, maturation, and projection of dopaminergic neurons has been proposed to be associated with several neurological and psychiatric disorders.
Claire Boissart, Marie Lasbareilles, Marie Lasbareilles, Marie Lasbareilles, Johana Tournois, Laure Chatrousse, Thifaine Poullion, Alexandra Benchoua, Alexandra Benchoua   +8 more
doaj   +1 more source

Alpha-synuclein disrupted dopamine homeostasis leads to dopaminergic neuron degeneration in Caenorhabditis elegans. [PDF]

PLoS ONE, 2010
Disruption of dopamine homeostasis may lead to dopaminergic neuron degeneration, a proposed explanation for the specific vulnerability of dopaminergic neurons in Parkinson's disease. While expression of human alpha-synuclein in C.
Pengxiu Cao, Yiyuan Yuan, Elizabeth A Pehek, Alex R Moise, Ying Huang, Krzysztof Palczewski, Zhaoyang Feng   +6 more
doaj   +1 more source

Opposing effects of β-2 and β-1 adrenergic receptor signaling on neuroinflammation and dopaminergic neuron survival in α-synuclein-mediated neurotoxicity

Journal of Neuroinflammation, 2023
Background Noradrenergic neurons in the locus coeruleus (LC) are the primary source of norepinephrine (NE) in the brain and degeneration of these neurons is reported in the early stages of Parkinson’s disease (PD), even prior to dopaminergic neuron ...
Daniel Torrente, Enming J. Su, Gerald P. Schielke, Mark Warnock, Kris Mann, Daniel A. Lawrence   +5 more
doaj   +1 more source