Results 1 to 10 of about 65,347 (261)

Phenotypic Reprogramming of Striatal Neurons Into Dopaminergic Neuron-Like Cells in the Adult Mouse Brain

Stem Cell Reports, 2018
Summary: Neuronal subtype is largely fixed in the adult mammalian brain. Here, however, we unexpectedly reveal that adult mouse striatal neurons can be reprogrammed into dopaminergic neuron-like cells (iDALs). This in vivo phenotypic reprogramming can be
Chun-Li Zhang, Tong Zang, Lei-Lei Wang
exaly   +3 more sources

MIRO1 mutation leads to metabolic maladaptation resulting in Parkinson’s disease-associated dopaminergic neuron loss [PDF]

npj Systems Biology and Applications
MIRO1 is a mitochondrial outer membrane protein important for mitochondrial distribution, dynamics and bioenergetics. Over the last decade, evidence has pointed to a link between MIRO1 and Parkinson’s disease (PD) pathogenesis.
Alise Zagare, Thomas Sauter, Kyriaki Barmpa, Maria Pacheco, Rejko Krüger, Jens Christian Schwamborn, Claudia Saraiva   +6 more
doaj   +2 more sources

Induced Dopaminergic Neurons: A New Promise for Parkinson’s Disease

Redox Biology, 2017
Motor symptoms that define Parkinson’s disease (PD) are caused by the selective loss of nigral dopaminergic (DA) neurons. Cell replacement therapy for PD has been focused on midbrain DA neurons derived from human fetal mesencephalic tissue, human ...
Jian Feng, Houbo Jiang
exaly   +3 more sources

Disulfidptosis contributes to rotenone-induced dopaminergic neuron damage [PDF]

Neural Regeneration Research
Parkinson’s disease is a neurodegenerative disorder whose pathogenesis remains incompletely understood. Rotenone exposure is reportedly associated with Parkinson’s disease.
Wenqi Ye, Qifu Zhang, Wei Ge, Haoyin Liu, Yaohui Shan, Feng Ye, Xiaogang Wang, Yuanpeng Zhao, Guorong Dan, Mingliang Chen, Yan Sai   +10 more
doaj   +2 more sources

The Parkinson’s disease-associated LRRK2-G2019S variant restricts serine metabolism, leading to microglial inflammation and dopaminergic neuron degeneration [PDF]

Journal of Neuroinflammation
A growing body of evidence implicates inflammation as a key hallmark in the pathophysiology of Parkinson’s disease (PD), with microglia playing a central role in mediating neuroinflammatory signaling in the brain.
Henry Kurniawan, Sarah L. Nickels, Alise Zagare, Elisa Zuccoli, Isabel Rosety, Gemma Gomez-Giro, Enrico Glaab, Jens C. Schwamborn   +7 more
doaj   +2 more sources

Sustained chemogenetic activation of locus coeruleus norepinephrine neurons promotes dopaminergic neuron survival in synucleinopathy

PLoS ONE, 2022
Dopaminergic neuron degeneration in the midbrain plays a pivotal role in motor symptoms associated with Parkinson’s disease. However, non-motor symptoms of Parkinson’s disease and post-mortem histopathology confirm dysfunction in other brain areas ...
Predrag Jovanovic, Yidan Wang, Jean-Philippe Vit, Edward Novinbakht, Nancy Morones, Elliot Hogg, Michele Tagliati, Celine E. Riera   +7 more
doaj   +2 more sources

Identification of signaling pathways modifying human dopaminergic neuron development using a pluripotent stem cell-based high-throughput screening automated system: purinergic pathways as a proof-of-principle

Frontiers in Pharmacology, 2023
Introduction: Alteration in the development, maturation, and projection of dopaminergic neurons has been proposed to be associated with several neurological and psychiatric disorders.
Claire Boissart, Marie Lasbareilles, Marie Lasbareilles, Marie Lasbareilles, Johana Tournois, Laure Chatrousse, Thifaine Poullion, Alexandra Benchoua, Alexandra Benchoua   +8 more
doaj   +1 more source

Alpha-synuclein disrupted dopamine homeostasis leads to dopaminergic neuron degeneration in Caenorhabditis elegans. [PDF]

PLoS ONE, 2010
Disruption of dopamine homeostasis may lead to dopaminergic neuron degeneration, a proposed explanation for the specific vulnerability of dopaminergic neurons in Parkinson's disease. While expression of human alpha-synuclein in C.
Pengxiu Cao, Yiyuan Yuan, Elizabeth A Pehek, Alex R Moise, Ying Huang, Krzysztof Palczewski, Zhaoyang Feng   +6 more
doaj   +1 more source

Opposing effects of β-2 and β-1 adrenergic receptor signaling on neuroinflammation and dopaminergic neuron survival in α-synuclein-mediated neurotoxicity

Journal of Neuroinflammation, 2023
Background Noradrenergic neurons in the locus coeruleus (LC) are the primary source of norepinephrine (NE) in the brain and degeneration of these neurons is reported in the early stages of Parkinson’s disease (PD), even prior to dopaminergic neuron ...
Daniel Torrente, Enming J. Su, Gerald P. Schielke, Mark Warnock, Kris Mann, Daniel A. Lawrence   +5 more
doaj   +1 more source

Inhibition of β-catenin dependent WNT signalling upregulates the transcriptional repressor NR0B1 and downregulates markers of an A9 phenotype in human embryonic stem cell-derived dopaminergic neurons: Implications for Parkinson's disease.

PLoS ONE, 2021
In this study we investigate how β-catenin-dependent WNT signalling impacts midbrain dopaminergic neuron (mDA) specification. mDA cultures at day 65 of differentiation responded to 25 days of the tankyrase inhibitor XAV969 (XAV, 100nM) with reduced ...
John M Haynes, Shanti M Sibuea, Alita A Aguiar, Fangwei Li, Joan K Ho, Colin W Pouton   +5 more
doaj   +1 more source