Results 1 to 10 of about 928,578 (204)

Modelling α-synuclein processing in primary patient cells for pharmacological intervention

Exploration of Medicine, 2023
Aim: Parkinson’s disease (PD) is a complex, chronic neurodegenerative disorder with predominately sporadic etiology. Intricate genetic-environmental interactions lead to the hallmarks of the disease: degeneration of dopaminergic neurons and the ...
Jessica K. Smith, George D. Mellick, Alex M. Sykes   +2 more
doaj   +2 more sources

Proteasome impairment by α-synuclein. [PDF]

PLoS ONE, 2017
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder worldwide and characterized by the loss of dopaminergic neurons in the patients' midbrains.
Lisa Zondler, Marcus Kostka, Patrick Garidel, Udo Heinzelmann, Bastian Hengerer, Benjamin Mayer, Jochen H Weishaupt, Frank Gillardon, Karin M Danzer   +8 more
doaj   +2 more sources

Preclinical development of a high affinity α-synuclein antibody, MEDI1341, that can enter the brain, sequester extracellular α-synuclein and attenuate α-synuclein spreading in vivo

Neurobiology of Disease, 2019
There are no approved drug therapies that can prevent or slow the progression of Parkinson's disease (PD). Accumulation and aggregation of α-synuclein protein is observed throughout the nervous system in PD. α-Synuclein is a core component of Lewy bodies
Lorraine Irving, Eliezer Masliah, Brian Spencer   +2 more
exaly   +3 more sources

Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies

, 2017
α-Synuclein misfolding and aggregation is a hallmark in Parkinson’s disease and in several other neurodegenerative diseases known as synucleinopathies. The toxic properties of α-synuclein are conserved from yeast to man, but the precise underpinnings of ...
Luisa V. Lopes (4181968), E´ va M. Szego (7743980), Francesca Munar (7744001), Ma´rcia Oliveira (7743998), Ivo C. Martins (1651531), Deborah Penque (2365399), Jochen Klucken (335764), Luı´s M. A. Oliveira (7743983), Markus Zweckstetter (133481), Carlo Breda (5076125), Eva F. Rodrigues (7744007), Tania Simoes (7744004), Hilal A. Lashuel (261037), Diana G. Ferreira (4006694), Nuno C. Santos (354057), Francisco J. Enguita (261452), Ruth Rott (7743995), Irina Zamolo (7744010), Simone Engelender (7744016), Hugo Vicente Miranda (3812248), Tiago F. Outeiro (191379), Flaviano Giorgini (58325), Olaf Riess (110686), Thomas M. Jovin (9674), Carlos Cordeiro (279493), Alexandre Quintas (232621), Michael Heinrich (1375335), Ekrem Darendelioglu (7743986), Ana Ponces-Freire (7744013), Marcos A. Gomes (7743992), Wei Xiang (46368), Rita M. de Oliveira (7743989)   +31 more
core   +6 more sources

Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation. [PDF]

PLoS ONE, 2011
Genetic and biochemical abnormalities of α-synuclein are associated with the pathogenesis of Parkinson's disease. In the present study we investigated the in vivo interaction of mouse and human α-synuclein with the potent parkinsonian neurotoxin, MPTP ...
Bobby Thomas, Allen S Mandir, Neva West, Ying Liu, Shaida A Andrabi, Wanda Stirling, Valina L Dawson, Ted M Dawson, Michael K Lee   +8 more
doaj   +1 more source

Pathological Relevance of Post-Translationally Modified Alpha-Synuclein (pSer87, pSer129, nTyr39) in Idiopathic Parkinson’s Disease and Multiple System Atrophy

Cells, 2022
Aggregated alpha-synuclein (α-synuclein) is the main component of Lewy bodies (LBs), Lewy neurites (LNs), and glial cytoplasmic inclusions (GCIs), which are pathological hallmarks of idiopathic Parkinson’s disease (IPD) and multiple system atrophy (MSA).
Berkiye Sonustun, Melek Firat Altay, Catherine Strand, Kirsten Ebanks, Geshanthi Hondhamuni, Thomas T. Warner, Hilal A. Lashuel, Rina Bandopadhyay   +7 more
doaj   +1 more source

Central and peripheral α‐synuclein in Parkinson disease detected by seed amplification assay

Annals of Clinical and Translational Neurology, 2023
Objectives Detection of α‐synuclein aggregates by seed amplification is a promising Parkinson disease biomarker assay. Understanding intraindividual relationships of α‐synuclein measures could inform optimal biomarker development.
Lana M. Chahine, Thomas G. Beach, Charles H. Adler, Monica Hepker, Anumantha Kanthasamy, Scott Appel, Sandra Pritzkow, Michelle Pinho, Sherri Mosovsky, Geidy E. Serrano, Christopher Coffey, Michael C. Brumm, Luis M. A. Oliveira, Jamie Eberling, Brit Mollenhauer, For the Systemic Synuclein Sampling Study   +15 more
doaj   +1 more source

Effects of Excess Brain-Derived Human α-Synuclein on Synaptic Vesicle Trafficking

Frontiers in Neuroscience, 2021
α-Synuclein is a presynaptic protein that regulates synaptic vesicle trafficking under physiological conditions. However, in several neurodegenerative diseases, including Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy, α ...
Cristina Román-Vendrell, Audrey T. Medeiros, John B. Sanderson, Haiyang Jiang, Tim Bartels, Jennifer R. Morgan   +5 more
doaj   +1 more source

Gut mucosal cells transfer α-synuclein to the vagus nerve

JCI Insight, 2023
Epidemiological and histopathological findings have raised the possibility that misfolded α-synuclein protein might spread from the gut to the brain and increase the risk of Parkinson’s disease.
Rashmi Chandra, Arpine Sokratian, Katherine R. Chavez, Stephanie King, Sandip M. Swain, Joshua C. Snyder, Andrew B. West, Rodger A. Liddle   +7 more
doaj   +1 more source

A β-Wrapin Targeting the N-Terminus of α-Synuclein Monomers Reduces Fibril-Induced Aggregation in Neurons

Frontiers in Neuroscience, 2021
Reducing α-synuclein pathology constitutes a plausible strategy against Parkinson’s disease. As we recently demonstrated, the β-wrapin protein AS69 binds an N-terminal region in monomeric α-synuclein, interferes with fibril nucleation, and reduces α ...
Éva M. Szegő, Fabian Boß, Daniel Komnig, Charlott Gärtner, Lennart Höfs, Hamed Shaykhalishahi, Hamed Shaykhalishahi, Michael M. Wördehoff, Theodora Saridaki, Jörg B. Schulz, Jörg B. Schulz, Wolfgang Hoyer, Wolfgang Hoyer, Björn H. Falkenburger, Björn H. Falkenburger, Björn H. Falkenburger, Björn H. Falkenburger   +16 more
doaj   +1 more source