Neurobiology of Disease, 2019 There are no approved drug therapies that can prevent or slow the progression of Parkinson's disease (PD). Accumulation and aggregation of α-synuclein protein is observed throughout the nervous system in PD. α-Synuclein is a core component of Lewy bodies
Lorraine Irving +2 more
exaly +3 more sources
Structural Basis for Dityrosine-Mediated Inhibition of α-Synuclein Fibrillization [PDF]
Journal of the American Chemical Society, 2022 α-Synuclein (α-Syn) is an intrinsically disordered protein which self-assembles into highly organized β-sheet structures that accumulate in plaques in brains of Parkinson's disease patients. Oxidative stress influences α-Syn structure and self-assembly; however, the basis for this remains unclear.
Cagla Sahin +19 more
openaire +6 more sources
Recruitment of Aβ into α‑Synuclein Condensates Catalyzes Primary Nucleation of α‑Synuclein Aggregation [PDF]
ACS Central ScienceOwen M. Morris +5 more
doaj +2 more sources
Resistance to MPTP-neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation. [PDF]
PLoS ONE, 2011 Genetic and biochemical abnormalities of α-synuclein are associated with the pathogenesis of Parkinson's disease. In the present study we investigated the in vivo interaction of mouse and human α-synuclein with the potent parkinsonian neurotoxin, MPTP ...
Bobby Thomas +8 more
doaj +1 more source
Cells, 2022 Aggregated alpha-synuclein (α-synuclein) is the main component of Lewy bodies (LBs), Lewy neurites (LNs), and glial cytoplasmic inclusions (GCIs), which are pathological hallmarks of idiopathic Parkinson’s disease (IPD) and multiple system atrophy (MSA).
Berkiye Sonustun +7 more
doaj +1 more source
On the ubiquity of helical α-synuclein tetramers [PDF]
Physical Chemistry Chemical Physics, 2019 The stability of oligomers linearly increases from dimers to octamers, but assembly of oligomers larger than tetramers requires high activation energies.
Liang Xu +2 more
openaire +2 more sources
Central and peripheral α‐synuclein in Parkinson disease detected by seed amplification assay
Annals of Clinical and Translational Neurology, 2023 Objectives Detection of α‐synuclein aggregates by seed amplification is a promising Parkinson disease biomarker assay. Understanding intraindividual relationships of α‐synuclein measures could inform optimal biomarker development.
Lana M. Chahine +15 more
doaj +1 more source
Effects of Excess Brain-Derived Human α-Synuclein on Synaptic Vesicle Trafficking
Frontiers in Neuroscience, 2021 α-Synuclein is a presynaptic protein that regulates synaptic vesicle trafficking under physiological conditions. However, in several neurodegenerative diseases, including Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy, α ...
Cristina Román-Vendrell +5 more
doaj +1 more source
α-Synuclein, oxidative stress and apoptosis from the perspective of a yeast model of Parkinson's disease [PDF]
FEMS Yeast Research, 2006 The neuronal protein alpha-synuclein (alpha-syn) has been suggested to be one of the factors linked to Parkinson's disease (PD). Several organisms, including the rat, mouse, worm, and fruit fly, are being used to study alpha-syn pathobiology. A new model organism was recently added to this armamentarium: the budding yeast Saccharomyces cerevisiae.
Stephan N, Witt, Todd R, Flower
openaire +2 more sources
Gut mucosal cells transfer α-synuclein to the vagus nerve
JCI Insight, 2023 Epidemiological and histopathological findings have raised the possibility that misfolded α-synuclein protein might spread from the gut to the brain and increase the risk of Parkinson’s disease.
Rashmi Chandra +7 more
doaj +1 more source