Results 21 to 30 of about 50,263 (243)

Structure activity relationship of phenolic acid inhibitors of α-synuclein fibril formation and toxicity [PDF]

Frontiers in Aging Neuroscience, 2014
The aggregation of α-synuclein (α-syn) is considered the key pathogenic event in many neurological disorders such as Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy, giving rise to a whole category of neurodegenerative diseases known as synucleinopathies.
Mustafa eArdah, Katerina ePaleologou, Guohua eLv, Salema eAbul Khair, Abdullah eAl Kendi, Saeed eMinhas, Taleb eAl-Tel, Abdulmonem eAl-Hayani, Mohammed eHaque, David eEliezer, Omar eEl-Agnaf, Omar eEl-Agnaf   +11 more
openaire   +3 more sources

Nigral proteasome inhibition in mice leads to motor and non-motor deficits and increased expression of Ser129 phosphorylated α-synuclein [PDF]

Frontiers in Behavioral Neuroscience, 2015
Parkinson's disease is a neurodegenerative disorder characterized by motor and non-motor disturbances. Various pathogenic pathways drive disease progression including oxidative stress, mitochondrial dysfunction, α-synuclein aggregation and impairment of protein degradation systems.
Bentea, Eduard, Van der Perren, Anke, Van Liefferinge, Joeri, El Arfani, Anissa, Albertini, Giulia, Demuyser, Thomas, Merckx, Ellen, Michotte, Yvette, Smolders, Ilse, Baekelandt, Veerle, Massie, Ann   +10 more
openaire   +4 more sources

Phosphatases of α-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of Parkinsonism [PDF]

Frontiers in Genetics, 2014
An important challenge in the field of Parkinson's disease (PD) is to develop disease modifying therapies capable of stalling or even halting disease progression. Coupled to this challenge is the need to identify disease biomarkers, in order to identify pre-symptomatic hallmarks of disease and monitor disease progression. The answer to these challenges
Taymans, Jean-Marc, Baekelandt, Veerle
openaire   +3 more sources

Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein

Acta Neuropathologica Communications, 2021
Pathologic inclusions composed of α-synuclein called Lewy pathology are hallmarks of Parkinson’s Disease (PD). Dominant inherited mutations in leucine rich repeat kinase 2 (LRRK2) are the most common genetic cause of PD.
Charlotte F. Brzozowski, Baraa A. Hijaz, Vijay Singh, Nolwazi Z. Gcwensa, Kaela Kelly, Edward S. Boyden, Andrew B. West, Deblina Sarkar, Laura A. Volpicelli-Daley   +8 more
doaj   +1 more source

Elevated levels of cerebrospinal fluid α-synuclein oligomers in healthy asymptomatic LRRK2 mutation carriers [PDF]

Frontiers in Aging Neuroscience, 2014
Mutations in the leucine-rich repeat kinase 2 gene are the most common cause of autosomal dominant Parkinson's disease (PD). To assess the cerebrospinal fluid (CSF) levels of α-synuclein oligomers in symptomatic and asymptomatic leucine-rich repeat kinase 2 mutation carriers, we used enzyme-linked immunosorbent assays (ELISA) to investigate total and ...
Aasly, Jan, Johansen, Krisztina, Brønstad, Gunnar, Warø, Bjørg Johanne, Majbour, NK, Varghese, S, Alzahmi, F, Paleologou, KE, Amer, DAM, Al-Hayani, A, El-Agnaf, OMA   +10 more
openaire   +4 more sources

α-Synuclein accumulates in huntingtin inclusions but forms independent filaments and its deficiency attenuates early phenotype in a mouse model of Huntington's disease [PDF]

Human Molecular Genetics, 2011
Huntington's disease (HD) is the most common of nine inherited neurological disorders caused by expanded polyglutamine (polyQ) sequences which confer propensity to self-aggregate and toxicity to their corresponding mutant proteins. It has been postulated that polyQ expression compromises the folding capacity of the cell which might affect other ...
Tomás Zapico, Cristina, Díez Zaera, María, Ferrer Abizanda, Isidre, Gómez Ramos, Pilar, Morán Cabré, María Asunción, Miras Portugal, María Teresa, Díaz Hernández, Miguel, Lucas Lozano, José Javier   +7 more
openaire   +4 more sources

Toxic Oligomeric Alpha-Synuclein Variants Present in Human Parkinson’s Disease Brains Are Differentially Generated in Mammalian Cell Models

Biomolecules, 2015
Misfolding and aggregation of α-synuclein into toxic soluble oligomeric α-synuclein aggregates has been strongly correlated with the pathogenesis of Parkinson’s disease (PD).
Wei Xin, Sharareh Emadi, Stephanie Williams, Qiang Liu, Philip Schulz, Ping He, Now Bahar Alam, Jie Wu, Michael R. Sierks   +8 more
doaj   +1 more source

A Rationally Designed Six-Residue Swap Generates Comparability in the Aggregation Behavior of α-Synuclein and β-Synuclein

Biochemistry, 2012
The aggregation process of α-synuclein, a protein closely associated with Parkinson's disease, is highly sensitive to sequence variations. It is therefore of great importance to understand the factors that define the aggregation propensity of specific mutational variants as well as their toxic behavior in the cellular environment.
Roodveldt C., Andersson A., De Genst E. J., Labrador-Garrido A., Buell A. K., Dobson C. M., Tartaglia G. G., Vendruscolo M.   +7 more
openaire   +4 more sources

Midbrain catecholaminergic neurons co-express α-synuclein and tau in progressive supranuclear palsy [PDF]

Frontiers in Neuroanatomy, 2015
To analyze the frequency and distribution of α-synuclein deposits in progressive supranuclear palsy (PSP).The brains of 25 cases of pathologically confirmed PSP were evaluated with immunohistochemistry for α-synuclein and tau. Multiple immunofluorescent stains were applied to analyze the expression of tau and α-synuclein aggregates in catecholaminergic
María Elena eErro Aguirre, María Victoria eZelaya, Javier eSánchez Ruiz de Gordoa, María Teresa eTuñón, José Luis eLanciego, José Luis eLanciego   +5 more
openaire   +4 more sources

Proteasome impairment by α-synuclein. [PDF]

PLoS ONE, 2017
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder worldwide and characterized by the loss of dopaminergic neurons in the patients' midbrains.
Lisa Zondler, Marcus Kostka, Patrick Garidel, Udo Heinzelmann, Bastian Hengerer, Benjamin Mayer, Jochen H Weishaupt, Frank Gillardon, Karin M Danzer   +8 more
doaj   +1 more source