Extracellular α-synuclein levels are regulated by neuronal activity
Molecular Neurodegeneration, 2018 Background α-Synuclein is a presynaptic protein abundant in the cytoplasmic compartment of neurons, whereas its presence in the extracellular space has also been observed under physiological conditions.
Kaoru Yamada, Takeshi Iwatsubo
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In-Cell NMR Characterization of the Secondary Structure Populations of a Disordered Conformation of α-Synuclein within E. coli Cells. [PDF]
, 2013 α-Synuclein is a small protein strongly implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders. We report here the use of in-cell NMR spectroscopy to observe directly the structure and dynamics of this protein ...
Christopher A. Waudby (238969) +46 more
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TOM40 Mediates Mitochondrial Dysfunction Induced by α-Synuclein Accumulation in Parkinson's Disease. [PDF]
, 2013 Alpha-synuclein (α-Syn) accumulation/aggregation and mitochondrial dysfunction play prominent roles in the pathology of Parkinson's disease. We have previously shown that postmortem human dopaminergic neurons from PD brains accumulate high levels of ...
Adame, Anthony +38 more
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Acta Neuropathologica Communications, 2021 Pathologic inclusions composed of α-synuclein called Lewy pathology are hallmarks of Parkinson’s Disease (PD). Dominant inherited mutations in leucine rich repeat kinase 2 (LRRK2) are the most common genetic cause of PD.
Charlotte F. Brzozowski +8 more
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Acetylated α-Tubulin and α-Synuclein: Physiological Interplay and Contribution to α-Synuclein Oligomerization [PDF]
, 2023 Emerging evidence supports that altered α-tubulin acetylation occurs in Parkinson’s disease (PD), a neurodegenerative disorder characterized by the deposition of α-synuclein fibrillary aggregates within Lewy bodies and nigrostriatal neuron degeneration ...
Rolando C. +8 more
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Identification of Proteins Involved in Microglial Endocytosis of α-Synuclein
, 2007 Aggregated α-synuclein, a protein playing pivotal roles in the pathogenesis of Parkinson disease (PD) and related synucleinopathy, has been shown to activate microglia, the key cells in neuroinflammation.
Yong Zhou (23772) +5 more
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Biomolecules, 2015 Misfolding and aggregation of α-synuclein into toxic soluble oligomeric α-synuclein aggregates has been strongly correlated with the pathogenesis of Parkinson’s disease (PD).
Wei Xin +8 more
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Mechanisms underlying extensive Ser129-phosphorylation in α-synuclein aggregates
Acta Neuropathologica Communications, 2017 Parkinson’s disease (PD) is characterized neuropathologically by intracellular aggregates of fibrillar α-synuclein, termed Lewy bodies (LBs). Approximately 90% of α-synuclein deposited as LBs is phosphorylated at Ser129 in brains with PD.
Shigeki Arawaka +4 more
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α-synuclein strains that cause distinct pathologies differentially inhibit proteasome
eLife, 2020 Abnormal α-synuclein aggregation has been implicated in several diseases and is known to spread in a prion-like manner. There is a relationship between protein aggregate structure (strain) and clinical phenotype in prion diseases, however, whether ...
Genjiro Suzuki +7 more
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The role of the endolysosomal pathway in α-synuclein pathogenesis in Parkinson’s disease
, 2023 Parkinson’s disease (PD) is a chronic neurodegenerative disease that is characterized by a loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain (SNpc).
Sykes, Alex M. +5 more
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