Results 31 to 40 of about 50,263 (243)

Mechanisms underlying extensive Ser129-phosphorylation in α-synuclein aggregates

Acta Neuropathologica Communications, 2017
Parkinson’s disease (PD) is characterized neuropathologically by intracellular aggregates of fibrillar α-synuclein, termed Lewy bodies (LBs). Approximately 90% of α-synuclein deposited as LBs is phosphorylated at Ser129 in brains with PD.
Shigeki Arawaka, Hiroyasu Sato, Asuka Sasaki, Shingo Koyama, Takeo Kato   +4 more
doaj   +1 more source

α-synuclein strains that cause distinct pathologies differentially inhibit proteasome

eLife, 2020
Abnormal α-synuclein aggregation has been implicated in several diseases and is known to spread in a prion-like manner. There is a relationship between protein aggregate structure (strain) and clinical phenotype in prion diseases, however, whether ...
Genjiro Suzuki, Sei Imura, Masato Hosokawa, Ryu Katsumata, Takashi Nonaka, Shin-Ichi Hisanaga, Yasushi Saeki, Masato Hasegawa   +7 more
doaj   +1 more source

Effects of baseline CSF α-synuclein on regional brain atrophy rates in healthy elders, mild cognitive impairment and Alzheimer's disease. [PDF]

PLoS ONE, 2013
BACKGROUND:Cerebrospinal fluid (CSF) α-synuclein is reduced in synucleinopathies, including dementia with Lewy bodies, and some studies have found increased CSF α-synuclein in Alzheimer's disease (AD).
Niklas Mattsson, Philip Insel, Duygu Tosun, Jing Zhang, Clifford R Jack, Douglas Galasko, Michael Weiner, Alzheimer’s Disease Neuroimaging Initiative   +7 more
doaj   +1 more source

MOESM6 of α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb

, 2019
Additional file 6. Microglial morphology analysis reveals no differences in microglial activation between groups.
Rey, Nolwen, Bousset, Luc, George, Sonia, Madaj, Zachary, Meyerdirk, Lindsay, Schulz, Emily, Steiner, Jennifer, Melki, Ronald, Brundin, Patrik   +8 more
openaire   +1 more source

Clinical Neuropathology image 5-2014: α-synuclein pathology in the ependyma in Parkinson’s disease [PDF]

Clinical Neuropathology, 2014
Not available.
openaire   +2 more sources

Ser129D mutant alpha-synuclein induces earlier motor dysfunction while S129A results in distinctive pathology in a rat model of Parkinson's disease

Neurobiology of Disease, 2013
Alpha-synuclein phosphorylated at serine 129 (S129) is highly elevated in Parkinson's disease patients where it mainly accumulates in the Lewy bodies. Several groups have studied the role of phosphorylation at the S129 in α-synuclein in a rat model for ...
Fabia Febbraro, Gurdal Sahin, Aina Farran, Sofia Soares, Poul H. Jensen, Deniz Kirik, Marina Romero-Ramos   +6 more
doaj   +1 more source

Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds

Acta Neuropathologica Communications, 2021
Peripheral administration (oral, intranasal, intraperitoneal, intravenous) of assembled A53T α-synuclein induced synucleinopathy in heterozygous mice transgenic for human mutant A53T α-synuclein (line M83).
Jennifer A. Macdonald, John L. Chen, Masami Masuda-Suzukake, Manuel Schweighauser, Zane Jaunmuktane, Thomas Warner, Janice L. Holton, Annabelle Grossman, Richard Berks, Isabelle Lavenir, Michel Goedert   +10 more
doaj   +1 more source

MOESM2 of α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb

, 2019
Additional file 2. List of antibodies, references and working concentrations.
Rey, Nolwen, Bousset, Luc, George, Sonia, Madaj, Zachary, Meyerdirk, Lindsay, Schulz, Emily, Steiner, Jennifer, Melki, Ronald, Brundin, Patrik   +8 more
openaire   +1 more source

Integrin CD11b mediates α-synuclein-induced activation of NADPH oxidase through a Rho-dependent pathway

Redox Biology, 2018
The activation of microglial NADPH oxidase (NOX2) induced by α-synuclein has been implicated in Parkinson's disease (PD) and other synucleinopathies. However, how α-synuclein activates NOX2 remains unclear. Previous study revealed that both toll-like receptor 2 (TLR2) and integrin play important roles in α-synuclein-induced microglial activation.
Liyan Hou, Xiuqi Bao, Caixia Zang, Hanyu Yang, Fuqiang Sun, Yuning Che, Xuefei Wu, Shao Li, Dan Zhang, Qingshan Wang   +9 more
openaire   +3 more sources

Alpha-synuclein increases in rodent and human spinal cord injury and promotes inflammation and tissue loss

Scientific Reports, 2021
Synucleinopathies are neurodegenerative diseases in which α-synuclein protein accumulates in neurons and glia. In these diseases, α-synuclein forms dense intracellular aggregates that are disease hallmarks and actively contribute to tissue pathology ...
Andrew D. Sauerbeck, Evan Z. Goldstein, Anthony N. Alfredo, Michael Norenberg, Alexander Marcillo, Dana M. McTigue   +5 more
doaj   +1 more source