Results 31 to 40 of about 83,002 (289)

Selective co-expression of synaptic proteins, α-synuclein, cysteine string protein-α, synaptophysin, synaptotagmin-1, and synaptobrevin-2 in vesicular acetylcholine transporter-immunoreactive axons in the guinea-pig ileum [PDF]

, 2013
Author version made available in accordance with publisher's policy.Parkinson's disease is a neurodegenerative disorder characterized by Lewy bodies and neurites composed mainly of the presynaptic protein α-synuclein. Frequently, Lewy bodies and neurites
Brookes, Simon Jonathan, Gai, Wei Ping, Sharrad, DF   +2 more
core   +1 more source

α-Synuclein accumulates in huntingtin inclusions but forms independent filaments and its deficiency attenuates early phenotype in a mouse model of Huntington's disease [PDF]

Human Molecular Genetics, 2011
Huntington's disease (HD) is the most common of nine inherited neurological disorders caused by expanded polyglutamine (polyQ) sequences which confer propensity to self-aggregate and toxicity to their corresponding mutant proteins. It has been postulated that polyQ expression compromises the folding capacity of the cell which might affect other ...
Tomás Zapico, Cristina, Díez Zaera, María, Ferrer Abizanda, Isidre, Gómez Ramos, Pilar, Morán Cabré, María Asunción, Miras Portugal, María Teresa, Díaz Hernández, Miguel, Lucas Lozano, José Javier   +7 more
openaire   +4 more sources

Proteasome impairment by α-synuclein. [PDF]

PLoS ONE, 2017
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder worldwide and characterized by the loss of dopaminergic neurons in the patients' midbrains.
Lisa Zondler, Marcus Kostka, Patrick Garidel, Udo Heinzelmann, Bastian Hengerer, Benjamin Mayer, Jochen H Weishaupt, Frank Gillardon, Karin M Danzer   +8 more
doaj   +1 more source

Prostaglandin E receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated α-synuclein [PDF]

, 2007
Background The pathogenesis of idiopathic Parkinson's disease (PD) remains elusive, although evidence has suggested that neuroinflammation characterized by activation of resident microglia in the brain may contribute significantly to neurodegeneration in
Schantz Aimee M, Davis Jeanne, Wang Yan, Liu Jun, Shie Feng-Shiun, Jin Jinghua, Montine Kathleen S, Montine Thomas J, Zhang Jing   +8 more
core   +2 more sources

A Rationally Designed Six-Residue Swap Generates Comparability in the Aggregation Behavior of α-Synuclein and β-Synuclein

Biochemistry, 2012
The aggregation process of α-synuclein, a protein closely associated with Parkinson's disease, is highly sensitive to sequence variations. It is therefore of great importance to understand the factors that define the aggregation propensity of specific mutational variants as well as their toxic behavior in the cellular environment.
Roodveldt C., Andersson A., De Genst E. J., Labrador-Garrido A., Buell A. K., Dobson C. M., Tartaglia G. G., Vendruscolo M.   +7 more
openaire   +4 more sources

Hypomethylation of intron1 of α-synuclein gene does not correlate with Parkinson’s disease [PDF]

, 2017
Deregulation of α-synuclein encoding gene (SNCA) is one of the important facets of Parkinson’s disease (PD) research. DNA methylation status of SNCA-intron1 has been shown to regulate the α-synuclein expression.
Baggio A. Evangelista, Sambuddha Basu, Subhrangshu Guhathakurta, Susmita Ghosh, Yoon-Seong Kim   +4 more
core   +1 more source

Mechanisms underlying extensive Ser129-phosphorylation in α-synuclein aggregates

Acta Neuropathologica Communications, 2017
Parkinson’s disease (PD) is characterized neuropathologically by intracellular aggregates of fibrillar α-synuclein, termed Lewy bodies (LBs). Approximately 90% of α-synuclein deposited as LBs is phosphorylated at Ser129 in brains with PD.
Shigeki Arawaka, Hiroyasu Sato, Asuka Sasaki, Shingo Koyama, Takeo Kato   +4 more
doaj   +1 more source

Redistribution of DAT/α-synuclein complexes visualized by “in situ” proximity ligation assay in transgenic mice modelling early Parkinson’s disease [PDF]

, 2011
Alpha-synuclein, the major component of Lewy bodies, is thought to play a central role in the onset of synaptic dysfunctions in Parkinson's disease (PD).
Bellucci A., Bono F., Collo G., Falarti E., Missale C., Navarria L., Spano P., Spillantini MG., Zaltieri M.   +8 more
core   +1 more source

α-synuclein strains that cause distinct pathologies differentially inhibit proteasome

eLife, 2020
Abnormal α-synuclein aggregation has been implicated in several diseases and is known to spread in a prion-like manner. There is a relationship between protein aggregate structure (strain) and clinical phenotype in prion diseases, however, whether ...
Genjiro Suzuki, Sei Imura, Masato Hosokawa, Ryu Katsumata, Takashi Nonaka, Shin-Ichi Hisanaga, Yasushi Saeki, Masato Hasegawa   +7 more
doaj   +1 more source

Effects of baseline CSF α-synuclein on regional brain atrophy rates in healthy elders, mild cognitive impairment and Alzheimer's disease. [PDF]

PLoS ONE, 2013
BACKGROUND:Cerebrospinal fluid (CSF) α-synuclein is reduced in synucleinopathies, including dementia with Lewy bodies, and some studies have found increased CSF α-synuclein in Alzheimer's disease (AD).
Niklas Mattsson, Philip Insel, Duygu Tosun, Jing Zhang, Clifford R Jack, Douglas Galasko, Michael Weiner, Alzheimer’s Disease Neuroimaging Initiative   +7 more
doaj   +1 more source