Results 11 to 20 of about 83,002 (289)
Structural Basis for Dityrosine-Mediated Inhibition of α-Synuclein Fibrillization [PDF]
Journal of the American Chemical Society, 2022 α-Synuclein (α-Syn) is an intrinsically disordered protein which self-assembles into highly organized β-sheet structures that accumulate in plaques in brains of Parkinson's disease patients. Oxidative stress influences α-Syn structure and self-assembly; however, the basis for this remains unclear.
Cagla Sahin +19 more
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On the ubiquity of helical α-synuclein tetramers [PDF]
Physical Chemistry Chemical Physics, 2019 The stability of oligomers linearly increases from dimers to octamers, but assembly of oligomers larger than tetramers requires high activation energies.
Liang Xu +2 more
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α-Synuclein, oxidative stress and apoptosis from the perspective of a yeast model of Parkinson's disease [PDF]
FEMS Yeast Research, 2006 The neuronal protein alpha-synuclein (alpha-syn) has been suggested to be one of the factors linked to Parkinson's disease (PD). Several organisms, including the rat, mouse, worm, and fruit fly, are being used to study alpha-syn pathobiology. A new model organism was recently added to this armamentarium: the budding yeast Saccharomyces cerevisiae.
Stephan N, Witt, Todd R, Flower
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Novel subcellular localization for α-synuclein: possible functional consequences [PDF]
Frontiers in Neuroanatomy, 2015 α-synuclein (α-syn) is one of the genes that when mutated or overexpressed causes Parkinson's Disease (PD). Initially, it was described as a synaptic terminal protein and later was found to be localized at mitochondria. Mitochondria-associated membranes (MAM) have emerged as a central endoplasmic reticulum (ER) subcellular compartments where key ...
Cristina eGuardia-Laguarta +4 more
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Detection of disease-associated α-synuclein in the cerebrospinal fluid: a feasibility study [PDF]
Clinical Neuropathology, 2014 With the aim to evaluate the significance and reliability of detecting disease-specific α-synuclein in the cerebrospinal fluid (CSF) we developed an ELISA and bead-assay. We used a commercial antibody (5G4) that does not bind to the physiological monomeric form of α-synuclein, but is highly specific for the disease-associated forms, including high ...
Unterberger, Ursula +9 more
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Lysosomes and α-synuclein form a dangerous duet leading to neuronal cell death [PDF]
Frontiers in Neuroanatomy, 2014 Neurodegenerative diseases are (i) characterized by a selective neuronal vulnerability to degeneration in specific brain regions; and (ii) likely to be caused by disease-specific protein misfolding. Parkinson's disease (PD) is characterized by the presence of intraneuronal proteinacious cytoplasmic inclusions, called Lewy Bodies (LB).
Mathieu eBourdenx +5 more
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O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease. [PDF]
, 2015 Several aggregation-prone proteins associated with neurodegenerative diseases can be modified by O-linked N-acetyl-glucosamine (O-GlcNAc) in vivo. One of these proteins, α-synuclein, is a toxic aggregating protein associated with synucleinopathies ...
Ambroso, Mark R +8 more
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Nutrient deprivation induces α-synuclein aggregation through endoplasmic reticulum stress response and SREBP2 pathway [PDF]
Frontiers in Aging Neuroscience, 2014 Abnormal accumulation of filamentous α-synuclein (α-syn) in neurons, regarded as Lewy bodies (LBs), are a hallmark of Parkinson disease (PD). Although the exact mechanism(s) underlying LBs formation remains unknown, autophagy and ER stress response have emerged as two important pathways affecting α-syn aggregation.
Jiang, Peizhou +3 more
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Frontiers in Neuroscience, 2018 Synucleinopathies represent a group of neurodegenerative disorders which are characterized by intracellular accumulation of aggregated α-synuclein. α-synuclein misfolding and oligomer formation is considered a major pathogenic trigger in these disorders.
Martin Kallab +8 more
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Chicago sky blue 6B inhibits α-synuclein aggregation and propagation
Molecular Brain, 2022 Abnormal deposition of α-synuclein aggregates in Lewy bodies and Lewy neurites is the hallmark lesion in Parkinson’s disease (PD). These aggregates, thought to be the culprit of disease pathogenesis, spread throughout the brain as the disease progresses.
Joo-Ok Min +4 more
doaj +1 more source