Results 41 to 50 of about 50,263 (243)

Modelling α-synuclein processing in primary patient cells for pharmacological intervention

Exploration of Medicine, 2023
Aim: Parkinson’s disease (PD) is a complex, chronic neurodegenerative disorder with predominately sporadic etiology. Intricate genetic-environmental interactions lead to the hallmarks of the disease: degeneration of dopaminergic neurons and the ...
Jessica K. Smith, George D. Mellick, Alex M. Sykes   +2 more
doaj   +1 more source

MOESM5 of α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb

, 2019
Additional file 5. Negative binomial mixed-effects model analysis of pser129 quantifications.
Rey, Nolwen, Bousset, Luc, George, Sonia, Madaj, Zachary, Meyerdirk, Lindsay, Schulz, Emily, Steiner, Jennifer, Melki, Ronald, Brundin, Patrik   +8 more
openaire   +1 more source

CD4 T cells react to local increase of α-synuclein in a pathology-associated variant-dependent manner and modify brain microglia in absence of brain pathology

Heliyon, 2018
We have previously shown that immunological processes in the brain during α-synuclein-induced neurodegeneration vary depending on the presence or absence of cell death.
Mads N. Olesen, Josefine R. Christiansen, Steen Vang Petersen, Poul Henning Jensen, Wojciech Paslawski, Marina Romero-Ramos, Vanesa Sanchez-Guajardo   +6 more
doaj   +1 more source

Design, Synthesis and Biological Evaluation of α-Synuclein Proteolysis-Targeting Chimeras

Molecules, 2023
α-Synuclein aggregation under pathological conditions is one of the causes of related neurodegenerative diseases. PROTACs (proteolysis targeting chimeras) are bifunctional small molecules that induce a post-translational erasure of proteins via the ...
Tianzhi Wen, Jian Chen, Wenqian Zhang, Jiyan Pang   +3 more
doaj   +1 more source

MOESM4 of α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb

, 2019
Additional file 4. List of the abbreviations of brain regions used in the figures.
Rey, Nolwen, Bousset, Luc, George, Sonia, Madaj, Zachary, Meyerdirk, Lindsay, Schulz, Emily, Steiner, Jennifer, Melki, Ronald, Brundin, Patrik   +8 more
openaire   +1 more source

Single-Channel Electrophysiology Reveals a Distinct and Uniform Pore Complex Formed by α-Synuclein Oligomers in Lipid Membranes

PLoS ONE, 2012
Synucleinopathies such as Parkinson's disease, multiple system atrophy and dementia with Lewy bodies are characterized by deposition of aggregated α-synuclein. Recent findings indicate that pathological oligomers rather than fibrillar aggregates may represent the main toxic protein species.
Schmidt, Felix, Levin, Johannes, Kamp, Frits, Kretzschmar, Hans, Giese, Armin, Botzel, Kai   +5 more
openaire   +7 more sources

MOESM3 of α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb

, 2019
Additional file 3. Examples of pser129-positive inclusions at high and low magnifications.
Rey, Nolwen, Bousset, Luc, George, Sonia, Madaj, Zachary, Meyerdirk, Lindsay, Schulz, Emily, Steiner, Jennifer, Melki, Ronald, Brundin, Patrik   +8 more
openaire   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Differential microglial responses to structurally distinct alpha-synuclein polymorphs

Molecular Brain
Synucleinopathies are age-related neurological disorders which include dementia with Lewy bodies (DLB), Parkinson’s disease (PD), and multiple system atrophy (MSA).
Katherine Chang, Jina Kim, Michiyo Iba, Jae-Hyeon Park, Alexandria Beilina, Zulfeqhar A. Syed, Valentina Baena, Liam Horan-Portelance, Mark R. Cookson, Sungyong You, Changyoun Kim   +10 more
doaj   +1 more source