Results 41 to 50 of about 83,002 (289)

Feasibility and Safety of Multicenter Tissue and Biofluid Sampling for α-Synuclein in Parkinson's Disease: The Systemic Synuclein Sampling Study (S4) [PDF]

, 2018
BACKGROUND: α-synuclein is a lead Parkinson's disease (PD) biomarker. There are conflicting reports regarding accuracy of α-synuclein in different tissues and biofluids as a PD biomarker, and the within-subject anatomical distribution of α-synuclein ...
Adler, Charles H., Arnedo, Vanessa, Beach, Thomas G., Brumm, Michael, Caspell-Garcia, Chelsea, Chahine, Lana M., Coffey, Christopher S., Dave, K.D., Ecklund, Dixie, Foroud, Tatiana, Jennings, Danna, Linder, Carly, Mollenhauer, Brit, Mosovsky, Sherri, Riley, Lindsey, Riss, Holly, Seedorff, Nicholas, Seibyl, John, Serrano, Geidy E., SystemicSynuclein Sampling study   +19 more
core   +1 more source

Quantitative Characterization of α-Synuclein Aggregation in Living Cells through Automated Microfluidics Feedback Control [PDF]

, 2019
Aggregation of α-synuclein and formation of inclusions are hallmarks of Parkinson's disease (PD). Aggregate formation is affected by cellular environment, but it has been studied almost exclusively in cell-free systems.
di Bernardo D., Perrino G, Santorelli M, Wilson C   +3 more
core   +1 more source

MOESM5 of α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb

, 2019
Additional file 5. Negative binomial mixed-effects model analysis of pser129 quantifications.
Rey, Nolwen, Bousset, Luc, George, Sonia, Madaj, Zachary, Meyerdirk, Lindsay, Schulz, Emily, Steiner, Jennifer, Melki, Ronald, Brundin, Patrik   +8 more
openaire   +1 more source

Clinical Neuropathology image 5-2014: α-synuclein pathology in the ependyma in Parkinson’s disease [PDF]

Clinical Neuropathology, 2014
Not available.
openaire   +2 more sources

Ser129D mutant alpha-synuclein induces earlier motor dysfunction while S129A results in distinctive pathology in a rat model of Parkinson's disease

Neurobiology of Disease, 2013
Alpha-synuclein phosphorylated at serine 129 (S129) is highly elevated in Parkinson's disease patients where it mainly accumulates in the Lewy bodies. Several groups have studied the role of phosphorylation at the S129 in α-synuclein in a rat model for ...
Fabia Febbraro, Gurdal Sahin, Aina Farran, Sofia Soares, Poul H. Jensen, Deniz Kirik, Marina Romero-Ramos   +6 more
doaj   +1 more source

Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson's disease model.

, 2019
Parkinson's disease (PD) is characterized by the presence of α-synuclein aggregates known as Lewy bodies and Lewy neurites, whose formation is linked to disease development. The causal relation between α-synuclein aggregates and PD is not well understood.
Anichtchik, O., Ashery, U., Bar-On, D., Calo’, L., Dalley, J., Giese, A., Griesinger, C., Iovino, M., Leonov, A., Ryazanov, S., Spillantini, M., Wegrzynowicz, M., Xia, J.   +12 more
core   +1 more source

MOESM2 of α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb

, 2019
Additional file 2. List of antibodies, references and working concentrations.
Rey, Nolwen, Bousset, Luc, George, Sonia, Madaj, Zachary, Meyerdirk, Lindsay, Schulz, Emily, Steiner, Jennifer, Melki, Ronald, Brundin, Patrik   +8 more
openaire   +1 more source

Alpha-synuclein increases in rodent and human spinal cord injury and promotes inflammation and tissue loss

Scientific Reports, 2021
Synucleinopathies are neurodegenerative diseases in which α-synuclein protein accumulates in neurons and glia. In these diseases, α-synuclein forms dense intracellular aggregates that are disease hallmarks and actively contribute to tissue pathology ...
Andrew D. Sauerbeck, Evan Z. Goldstein, Anthony N. Alfredo, Michael Norenberg, Alexander Marcillo, Dana M. McTigue   +5 more
doaj   +1 more source

Modelling α-synuclein processing in primary patient cells for pharmacological intervention

Exploration of Medicine, 2023
Aim: Parkinson’s disease (PD) is a complex, chronic neurodegenerative disorder with predominately sporadic etiology. Intricate genetic-environmental interactions lead to the hallmarks of the disease: degeneration of dopaminergic neurons and the ...
Jessica K. Smith, George D. Mellick, Alex M. Sykes   +2 more
doaj   +1 more source

MOESM4 of α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb

, 2019
Additional file 4. List of the abbreviations of brain regions used in the figures.
Rey, Nolwen, Bousset, Luc, George, Sonia, Madaj, Zachary, Meyerdirk, Lindsay, Schulz, Emily, Steiner, Jennifer, Melki, Ronald, Brundin, Patrik   +8 more
openaire   +1 more source