Results 41 to 50 of about 50,531 (144)

Integrin CD11b mediates α-synuclein-induced activation of NADPH oxidase through a Rho-dependent pathway

Redox Biology, 2018
The activation of microglial NADPH oxidase (NOX2) induced by α-synuclein has been implicated in Parkinson's disease (PD) and other synucleinopathies. However, how α-synuclein activates NOX2 remains unclear. Previous study revealed that both toll-like receptor 2 (TLR2) and integrin play important roles in α-synuclein-induced microglial activation.
Liyan Hou, Xiuqi Bao, Caixia Zang, Hanyu Yang, Fuqiang Sun, Yuning Che, Xuefei Wu, Shao Li, Dan Zhang, Qingshan Wang   +9 more
openaire   +3 more sources

Modelling α-synuclein processing in primary patient cells for pharmacological intervention

Exploration of Medicine, 2023
Aim: Parkinson’s disease (PD) is a complex, chronic neurodegenerative disorder with predominately sporadic etiology. Intricate genetic-environmental interactions lead to the hallmarks of the disease: degeneration of dopaminergic neurons and the ...
Jessica K. Smith, George D. Mellick, Alex M. Sykes   +2 more
doaj   +1 more source

Additional file 1: of Immature-like molecular expression patterns in the hippocampus of a mouse model of dementia with Lewy body-linked mutant β-synuclein

, 2018
Materials and Methods. Table S1. Raw data of qPCR analysis (average Cq value). Figure S1. Immunohistochemical images used for quantitative analysis in this study. (DOCX 25253 kb)
Hagihara, Hideo, Fujita, Masayo, Umemori, Juzoh, Hashimoto, Makoto, Miyakawa, Tsuyoshi   +4 more
openaire   +1 more source

Alpha-synuclein increases in rodent and human spinal cord injury and promotes inflammation and tissue loss

Scientific Reports, 2021
Synucleinopathies are neurodegenerative diseases in which α-synuclein protein accumulates in neurons and glia. In these diseases, α-synuclein forms dense intracellular aggregates that are disease hallmarks and actively contribute to tissue pathology ...
Andrew D. Sauerbeck, Evan Z. Goldstein, Anthony N. Alfredo, Michael Norenberg, Alexander Marcillo, Dana M. McTigue   +5 more
doaj   +1 more source

Design, Synthesis and Biological Evaluation of α-Synuclein Proteolysis-Targeting Chimeras

Molecules, 2023
α-Synuclein aggregation under pathological conditions is one of the causes of related neurodegenerative diseases. PROTACs (proteolysis targeting chimeras) are bifunctional small molecules that induce a post-translational erasure of proteins via the ...
Tianzhi Wen, Jian Chen, Wenqian Zhang, Jiyan Pang   +3 more
doaj   +1 more source

Single-Channel Electrophysiology Reveals a Distinct and Uniform Pore Complex Formed by α-Synuclein Oligomers in Lipid Membranes

PLoS ONE, 2012
Synucleinopathies such as Parkinson's disease, multiple system atrophy and dementia with Lewy bodies are characterized by deposition of aggregated α-synuclein. Recent findings indicate that pathological oligomers rather than fibrillar aggregates may represent the main toxic protein species.
Schmidt, Felix, Levin, Johannes, Kamp, Frits, Kretzschmar, Hans, Giese, Armin, Botzel, Kai   +5 more
openaire   +7 more sources

CD4 T cells react to local increase of α-synuclein in a pathology-associated variant-dependent manner and modify brain microglia in absence of brain pathology

Heliyon, 2018
We have previously shown that immunological processes in the brain during α-synuclein-induced neurodegeneration vary depending on the presence or absence of cell death.
Mads N. Olesen, Josefine R. Christiansen, Steen Vang Petersen, Poul Henning Jensen, Wojciech Paslawski, Marina Romero-Ramos, Vanesa Sanchez-Guajardo   +6 more
doaj   +1 more source

Limited effects of dysfunctional macroautophagy on the accumulation of extracellularly derived α-synuclein in oligodendroglia: implications for MSA pathogenesis

BMC Neuroscience, 2018
Background The progressive neurodegenerative disorder multiple system atrophy (MSA) is characterized by α-synuclein-positive (oligodendro-) glial cytoplasmic inclusions (GCIs).
Lisa Fellner, Edith Buchinger, Dominik Brueck, Regina Irschick, Gregor K. Wenning, Nadia Stefanova   +5 more
doaj   +1 more source

Differential microglial responses to structurally distinct alpha-synuclein polymorphs

Molecular Brain
Synucleinopathies are age-related neurological disorders which include dementia with Lewy bodies (DLB), Parkinson’s disease (PD), and multiple system atrophy (MSA).
Katherine Chang, Jina Kim, Michiyo Iba, Jae-Hyeon Park, Alexandria Beilina, Zulfeqhar A. Syed, Valentina Baena, Liam Horan-Portelance, Mark R. Cookson, Sungyong You, Changyoun Kim   +10 more
doaj   +1 more source

The role of autophagy in synucleinopathy: clearance versus spread of α-synuclein

Autophagy Reports
Emerging evidence suggests that the propagation of α-synuclein pathology underlies the progression of Parkinson’s disease and supports the hypothesis that transmission of α-synuclein aggregates contributes to dopaminergic degeneration.
Emily Birnbaum, Zhenyu Yue
doaj   +1 more source