Results 61 to 70 of about 50,531 (144)
npj Parkinson's Disease, 2021 Olfactory dysfunction is an early pre-motor symptom of Parkinson’s disease (PD) but the neural mechanisms underlying this dysfunction remain largely unknown. Aggregation of α-synuclein is observed in the olfactory bulb (OB) during the early stages of PD,
Fengjiao Chen +6 more
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The E46K mutation modulates α-synuclein prion replication in transgenic mice
PLoS Pathogens, 2022 In multiple system atrophy (MSA), the α-synuclein protein misfolds into a self-templating prion conformation that spreads throughout the brain, leading to progressive neurodegeneration.
Sara A. M. Holec +11 more
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Molecular ageing of alpha- and Beta-synucleins: protein damage and repair mechanisms. [PDF]
PLoS ONE, 2013 Abnormal α-synuclein aggregates are hallmarks of a number of neurodegenerative diseases. Alpha synuclein and β-synucleins are susceptible to post-translational modification as isoaspartate protein damage, which is regulated in vivo by the action of the ...
Vasanthy Vigneswara +5 more
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α-Synuclein interacts directly but reversibly with psychosine: implications for α-synucleinopathies
Scientific Reports, 2018 Aggregation of α-synuclein, the hallmark of α-synucleinopathies such as Parkinson’s disease, occurs in various glycosphingolipidoses. Although α-synuclein aggregation correlates with deficiencies in the lysosomal degradation of glycosphingolipids (GSL ...
Hazem Abdelkarim +15 more
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Cell Reports, 2016 Ample evidence suggests that α-synuclein is released from cells and propagated from one area of the brain to others via cell-to-cell transmission. In terms of their prion-like behavior, α-synuclein propagation plays key roles in the pathogenesis and ...
Se Hee Oh +7 more
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Neuroprotective function of Omi to α-synuclein-induced neurotoxicity
Neurobiology of Disease, 2020 Astract: The main pathological hallmark of Parkinson's disease (PD) is the presence of Lewy bodies, which mainly consist of aggregated α-synuclein. Based on the neurotoxicity of oligomeric α-synuclein and its significance in the aetiology of PD, there ...
Hea-Jong Chung +3 more
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Intracellular Catalytic Photooxygenation of α‐Synuclein Amyloid
ChemistryEuropeThe amyloid aggregation of α‐synuclein is a central pathological hallmark of various synucleinopathies, including Parkinson disease. Consequently, developing strategies to eliminate α‐synuclein amyloids represents a promising therapeutic approach.
Atsushi Iwai +11 more
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Lack of pathogenic potential of peripheral α-synuclein aggregates from Parkinson’s disease patients
Acta Neuropathologica Communications, 2018 In Parkinson’s disease (PD) there is widespread accumulation in the brain of abnormal α-synuclein aggregates forming intraneuronal Lewy bodies (LB). It is now well established that LB-type α-synuclein aggregates also occur in the peripheral autonomic ...
Ariadna Recasens +6 more
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npj Parkinson's Diseaseα-Synuclein proximity ligation assay (PLA) has proved a sensitive technique for detection of non-Lewy body α-synuclein aggregate pathology. Here, we describe the MJF-14 PLA, a new PLA towards aggregated α-synuclein with unprecedented specificity, using ...
Nanna Møller Jensen +14 more
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Polo-like kinase 2 modulates α-synuclein protein levels by regulating its mRNA production
Neurobiology of Disease, 2017 Variations in the α-synuclein-encoding SNCA gene represent the greatest genetic risk factor for Parkinson's disease (PD), and duplications/triplications of SNCA cause autosomal dominant familial PD.
Rikke H. Kofoed +9 more
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