Results 61 to 70 of about 83,002 (289)

Pramipexole reduces phosphorylation of α-Synuclein at Serine-129 [PDF]

, 2013
α-Synuclein is a central component of the pathogenesis of Parkinson's disease (PD). Phosphorylation at serine-129 represents an important post-translational modification and constitutes the major form of the protein in Lewy bodies.
Chau, KY, Cooper, JM, Schapira, AH
core   +1 more source

MOESM1 of α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb

, 2019
Additional file 1. Quality control of the assemblies.
Rey, Nolwen, Bousset, Luc, George, Sonia, Madaj, Zachary, Meyerdirk, Lindsay, Schulz, Emily, Steiner, Jennifer, Melki, Ronald, Brundin, Patrik   +8 more
openaire   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Differential microglial responses to structurally distinct alpha-synuclein polymorphs

Molecular Brain
Synucleinopathies are age-related neurological disorders which include dementia with Lewy bodies (DLB), Parkinson’s disease (PD), and multiple system atrophy (MSA).
Katherine Chang, Jina Kim, Michiyo Iba, Jae-Hyeon Park, Alexandria Beilina, Zulfeqhar A. Syed, Valentina Baena, Liam Horan-Portelance, Mark R. Cookson, Sungyong You, Changyoun Kim   +10 more
doaj   +1 more source

α-Synuclein pathology from the body to the brain: so many seeds so close to the central soil

Neural Regeneration Research
α-Synuclein is a protein that mainly exists in the presynaptic terminals. Abnormal folding and accumulation of α-synuclein are found in several neurodegenerative diseases, including Parkinson’s disease.
Yunying Yang, Zhentao Zhang
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

The role of autophagy in synucleinopathy: clearance versus spread of α-synuclein

Autophagy Reports
Emerging evidence suggests that the propagation of α-synuclein pathology underlies the progression of Parkinson’s disease and supports the hypothesis that transmission of α-synuclein aggregates contributes to dopaminergic degeneration.
Emily Birnbaum, Zhenyu Yue
doaj   +1 more source

GM1 Ganglioside Modifies α-Synuclein Toxicity and is Neuroprotective in a Rat α-Synuclein Model of Parkinson\u27s Disease. [PDF]

, 2019
While GM1 may interact with α-synuclein in vitro to inhibit aggregation, the ability of GM1 to protect against α-synuclein toxicity in vivo has not been investigated.
Aras, Radha, Brotchie, Jonathan M., Koprich, James B., Schneider, Jay S., Singh, Vikrant, Williams, Courtney K.   +5 more
core   +1 more source

Proteinopathy, oxidative stress and mitochondrial dysfunction: cross talk in alzheimer’s disease and parkinson’s disease [PDF]

, 2017
Alzheimer's disease and Parkinson's disease are two common neurodegenerative diseases of the elderly people that have devastating effects in terms of morbidity and mortality.
Chakrabarti, S., Chatterjee, U., Ganguly, G., Saso, L.   +3 more
core   +3 more sources

Additional file 1: of Immature-like molecular expression patterns in the hippocampus of a mouse model of dementia with Lewy body-linked mutant β-synuclein

, 2018
Materials and Methods. Table S1. Raw data of qPCR analysis (average Cq value). Figure S1. Immunohistochemical images used for quantitative analysis in this study. (DOCX 25253 kb)
Hagihara, Hideo, Fujita, Masayo, Juzoh Umemori, Hashimoto, Makoto, Miyakawa, Tsuyoshi   +4 more
openaire   +1 more source