Results 51 to 60 of about 83,002 (289)

Integrin CD11b mediates α-synuclein-induced activation of NADPH oxidase through a Rho-dependent pathway

Redox Biology, 2018
The activation of microglial NADPH oxidase (NOX2) induced by α-synuclein has been implicated in Parkinson's disease (PD) and other synucleinopathies. However, how α-synuclein activates NOX2 remains unclear. Previous study revealed that both toll-like receptor 2 (TLR2) and integrin play important roles in α-synuclein-induced microglial activation.
Liyan Hou, Xiuqi Bao, Caixia Zang, Hanyu Yang, Fuqiang Sun, Yuning Che, Xuefei Wu, Shao Li, Dan Zhang, Qingshan Wang   +9 more
openaire   +3 more sources

CD4 T cells react to local increase of α-synuclein in a pathology-associated variant-dependent manner and modify brain microglia in absence of brain pathology

Heliyon, 2018
We have previously shown that immunological processes in the brain during α-synuclein-induced neurodegeneration vary depending on the presence or absence of cell death.
Mads N. Olesen, Josefine R. Christiansen, Steen Vang Petersen, Poul Henning Jensen, Wojciech Paslawski, Marina Romero-Ramos, Vanesa Sanchez-Guajardo   +6 more
doaj   +1 more source

Design, Synthesis and Biological Evaluation of α-Synuclein Proteolysis-Targeting Chimeras

Molecules, 2023
α-Synuclein aggregation under pathological conditions is one of the causes of related neurodegenerative diseases. PROTACs (proteolysis targeting chimeras) are bifunctional small molecules that induce a post-translational erasure of proteins via the ...
Tianzhi Wen, Jian Chen, Wenqian Zhang, Jiyan Pang   +3 more
doaj   +1 more source

Optimizing Western Blots for the Detection of Endogenous α-Synuclein in the Enteric Nervous System [PDF]

, 2015
Background:Alpha-synuclein containing inclusions in neurons, the characteristic pathological lesions of Parkinson’s disease (PD), are not limited to the central nervous system, but also affect the enteric nervous system (ENS).
A.G. Corbillé, C. Preterre, F. Letournel, G. Balloy, M. Neunlist, P. Derkinderen   +5 more
core   +3 more sources

MOESM3 of α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb

, 2019
Additional file 3. Examples of pser129-positive inclusions at high and low magnifications.
Rey, Nolwen, Bousset, Luc, George, Sonia, Madaj, Zachary, Meyerdirk, Lindsay, Schulz, Emily, Steiner, Jennifer, Melki, Ronald, Brundin, Patrik   +8 more
openaire   +1 more source

Clearing extracellular alpha-synuclein from cerebrospinal fluid: A new therapeutic strategy in parkinson’s disease [PDF]

, 2018
This concept article aims to show the rationale of targeting extracellular α-Synuclein (α-Syn) from cerebrospinal fluid (CSF) as a new strategy to remove this protein from the brain in Parkinson’s disease (PD). Misfolding and intracellular aggregation of
Fernández García, Benjamín, Menéndez González, Manuel, Padilla Zambrano, H. S., Tomás Zapico, Cristina   +3 more
core   +3 more sources

MOESM6 of α-Synuclein conformational strains spread, seed and target neuronal cells differentially after injection into the olfactory bulb

, 2019
Additional file 6. Microglial morphology analysis reveals no differences in microglial activation between groups.
Rey, Nolwen, Bousset, Luc, George, Sonia, Madaj, Zachary, Meyerdirk, Lindsay, Schulz, Emily, Steiner, Jennifer, Melki, Ronald, Brundin, Patrik   +8 more
openaire   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds

Acta Neuropathologica Communications, 2021
Peripheral administration (oral, intranasal, intraperitoneal, intravenous) of assembled A53T α-synuclein induced synucleinopathy in heterozygous mice transgenic for human mutant A53T α-synuclein (line M83).
Jennifer A. Macdonald, John L. Chen, Masami Masuda-Suzukake, Manuel Schweighauser, Zane Jaunmuktane, Thomas Warner, Janice L. Holton, Annabelle Grossman, Richard Berks, Isabelle Lavenir, Michel Goedert   +10 more
doaj   +1 more source

Structures of fibrils formed by α-synuclein hereditary disease mutant H50Q reveal new polymorphs. [PDF]

, 2019
Deposits of amyloid fibrils of α-synuclein are the histological hallmarks of Parkinson's disease, dementia with Lewy bodies and multiple system atrophy, with hereditary mutations in α-synuclein linked to the first two of these conditions.
Boyer, David R, Eisenberg, David S, Fan, Weijia, Jiang, Lin, Li, Binsen, Sawaya, Michael R, Sun, Chuanqi   +6 more
core