Results 51 to 60 of about 50,531 (144)

α-Synuclein pathology from the body to the brain: so many seeds so close to the central soil

Neural Regeneration Research
α-Synuclein is a protein that mainly exists in the presynaptic terminals. Abnormal folding and accumulation of α-synuclein are found in several neurodegenerative diseases, including Parkinson’s disease.
Yunying Yang, Zhentao Zhang
doaj   +1 more source

β-synuclein regulates the phase transitions and amyloid conversion of α-synuclein

Nature Communications
Parkinson’s disease (PD) and Dementia with Lewy Bodies (DLB) are neurodegenerative disorders characterized by the accumulation of α-synuclein aggregates. α-synuclein forms droplets via liquid-liquid phase separation (LLPS), followed by liquid-solid phase
Xi Li, Linwei Yu, Xikai Liu, Tianyi Shi, Yu Zhang, Yushuo Xiao, Chen Wang, Liangliang Song, Ning Li, Xinran Liu, Yuchen Chen, Robert B. Petersen, Xiang Cheng, Weikang Xue, Yanxun V. Yu, Li Xu, Ling Zheng, Hong Chen, Kun Huang   +18 more
doaj   +1 more source

Effect of the micro-environment on α-synuclein conversion and implication in seeded conversion assays

Translational Neurodegeneration, 2020
Background α-Synuclein is a small soluble protein, whose physiological function in the healthy brain is poorly understood. Intracellular inclusions of α-synuclein, referred to as Lewy bodies (LBs), are pathological hallmarks of α-synucleinopathies, such ...
Niccolo Candelise, Matthias Schmitz, Katrin Thüne, Maria Cramm, Alberto Rabano, Saima Zafar, Erik Stoops, Hugo Vanderstichele, Anna Villar-Pique, Franc Llorens, Inga Zerr   +10 more
doaj   +1 more source

Inhibition of copper transporter 1 prevents α-synuclein pathology and alleviates nigrostriatal degeneration in AAV-based mouse model of Parkinson's disease

Redox Biology, 2021
The formation of α-synuclein aggregates is a major pathological hallmark of Parkinson's disease. Copper promotes α-synuclein aggregation and toxicity in vitro.
De-Hai Gou, Ting-Ting Huang, Wen Li, Xin-Di Gao, Caroline Haikal, Xin-He Wang, Dong-Yan Song, Xin Liang, Lin Zhu, Yong Tang, Chen Ding, Jia-Yi Li   +11 more
doaj   +1 more source

Alcohol consumers with liver pathology rarely display α-synuclein pathology

Acta Neuropathologica
AbstractIt has been suggested that alcohol consumption protects against Parkinson's disease (PD). Here we assessed postmortem tissue samples from the brains and livers of 100 subjects with ages at death ranging from 51 to 93. Twenty percent of these subjects were demented.
Sylwia Libard, Fredrik Tamsen, Irina Alafuzoff   +2 more
openaire   +3 more sources

Differential expression of alpha-synuclein in hippocampal neurons.

PLoS ONE, 2014
α-Synuclein is the major pathological component of synucleinopathies including Parkinson's disease and dementia with Lewy bodies. Recent studies have demonstrated that α-synuclein also plays important roles in the release of synaptic vesicles and ...
Katsutoshi Taguchi, Yoshihisa Watanabe, Atsushi Tsujimura, Harutsugu Tatebe, Seiji Miyata, Takahiko Tokuda, Toshiki Mizuno, Masaki Tanaka   +7 more
doaj   +1 more source

Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds

Acta Neuropathologica Communications, 2021
Peripheral administration (oral, intranasal, intraperitoneal, intravenous) of assembled A53T α-synuclein induced synucleinopathy in heterozygous mice transgenic for human mutant A53T α-synuclein (line M83).
Jennifer A. Macdonald, John L. Chen, Masami Masuda-Suzukake, Manuel Schweighauser, Zane Jaunmuktane, Thomas Warner, Janice L. Holton, Annabelle Grossman, Richard Berks, Isabelle Lavenir, Michel Goedert   +10 more
doaj   +1 more source

DEAD-box RNA helicase Dbp4/DDX10 is an enhancer of α-synuclein toxicity and oligomerization.

PLoS Genetics, 2021
Parkinson's disease is a neurodegenerative disorder associated with misfolding and aggregation of α-synuclein as a hallmark protein. Two yeast strain collections comprising conditional alleles of essential genes were screened for the ability of each ...
Blagovesta Popova, Dan Wang, Christina Pätz, Dagmar Akkermann, Diana F Lázaro, Dajana Galka, Miriam Kolog Gulko, Markus T Bohnsack, Wiebke Möbius, Katherine E Bohnsack, Tiago F Outeiro, Gerhard H Braus   +11 more
doaj   +1 more source

Cofilin 1 promotes the pathogenicity and transmission of pathological α-synuclein in mouse models of Parkinson’s disease

npj Parkinson's Disease, 2022
The pathological hallmark of Parkinson’s disease (PD) is the presence of Lewy bodies (LBs) with aggregated α-synuclein being the major component. The abnormal α-synuclein aggregates transfer between cells, recruit endogenous α-synuclein into toxic LBs ...
Mingmin Yan, Min Xiong, Lijun Dai, Xingyu Zhang, Yunhong Zha, Xiaorong Deng, Zhui Yu, Zhentao Zhang   +7 more
doaj   +1 more source

Plasma and Serum Alpha-Synuclein as a Biomarker of Diagnosis in Patients With Parkinson's Disease

Frontiers in Neurology, 2020
Background: Parkinson's disease (PD) is the second most common neurodegenerative disease, and α-synuclein plays a critical role in the pathogenesis of PD.
Chun-Wei Chang, Shieh-Yueh Yang, Che-Chuan Yang, Chia-Wen Chang, Yih-Ru Wu, Yih-Ru Wu   +5 more
doaj   +1 more source