Results 71 to 80 of about 50,531 (144)

α-Synuclein strain propagation is independent of cellular prion protein expression in a transgenic synucleinopathy mouse model.

PLoS Pathogens
The cellular prion protein, PrPC, has been postulated to function as a receptor for α-synuclein, potentially facilitating cell-to-cell spreading and/or toxicity of α-synuclein aggregates in neurodegenerative disorders such as Parkinson's disease ...
Raphaella W L So, Genki Amano, Erica Stuart, Aeen Ebrahim Amini, Adriano Aguzzi, Graham L Collingridge, Joel C Watts   +6 more
doaj   +1 more source

Elevated plasma levels of alpha-synuclein are dispensable for Parkinson’s disease pathology

npj Parkinson's Disease
Although α-synuclein levels are elevated in the blood plasma of Parkinson’s disease (PD) patients, it remains unclear whether blood-derived α-synuclein directly contributes to PD.
Jin-Young Jeong, Namsuk Kim, Yan Li, Doo-Jin Kim, Hyong Kyu Kim, Won-Jong Oh   +5 more
doaj   +1 more source

Low-density lipoprotein receptor–related protein 1 mediates α-synuclein transmission from the striatum to the substantia nigra in animal models of Parkinson’s disease

Neural Regeneration Research
α-Synuclein accumulation and transmission are vital to the pathogenesis of Parkinson’s disease, although the mechanisms underlying misfolded α-synuclein accumulation and propagation have not been conclusively determined.
Hanjiang Luo, Caixia Peng, Chengli Wu, Chengwei Liu, Qinghua Li, Shun Yu, Jia Liu, Min Chen   +7 more
doaj   +1 more source

Host-to-graft propagation of inoculated α-synuclein into transplanted human induced pluripotent stem cell-derived midbrain dopaminergic neurons

Regenerative Therapy
Introduction: Cell therapeutic clinical trials using fetal mesencephalic tissue provided a proof-of-concept for regenerative therapy in patients with Parkinson's disease.
Serina Gima, Kazuya Oe, Kaneyasu Nishimura, Takashi Ohgita, Haruka Ito, Hiroyuki Kimura, Hiroyuki Saito, Kazuyuki Takata   +7 more
doaj   +1 more source

The amplification of α-synuclein amyloid fibrils. [PDF]

Biochem Soc Trans
Buell AK.
europepmc   +1 more source

Protocol for using an ELISA to detect total α-synuclein levels in Drosophila melanogaster lines expressing human α-synuclein point mutations. [PDF]

STAR Protoc
Sciortino M, Velazquez R, Tillmon H, Banerjee S.   +3 more
europepmc   +1 more source

Fragmentation-Induced Disassembly and Reaggregation of α-Synuclein Amyloid Fibrils. [PDF]

ACS Chem Neurosci
Havemeister F, Halipi V, Ghaeidamini M, Esbjörner EK.   +3 more
europepmc   +1 more source

The NLRP3-α-Synuclein Circuit: A Core Driver and Therapeutic Target in Parkinson's Disease. [PDF]

J Inflamm Res
Liu K, He Z, Zhang L, Wu YM, Xiao L.
europepmc   +1 more source

Transient Interactions of α-Synuclein N- and C-Termini. [PDF]

ACS Chem Neurosci
Ortigosa-Pascual L, Ferrante Carrante N, Bernfur K, Makasewicz K, Sparr E, Linse S.   +5 more
europepmc   +1 more source

Propagation of α-synuclein pathology: models, mechanisms and future goals. [PDF]

Mol Neurodegener Adv
Zolin A, Weber SA, Xie YX, Burré J.
europepmc   +1 more source