Results 71 to 80 of about 928,578 (204)

α-Synuclein interacts directly but reversibly with psychosine: implications for α-synucleinopathies

Scientific Reports, 2018
Aggregation of α-synuclein, the hallmark of α-synucleinopathies such as Parkinson’s disease, occurs in various glycosphingolipidoses. Although α-synuclein aggregation correlates with deficiencies in the lysosomal degradation of glycosphingolipids (GSL ...
Hazem Abdelkarim, Michael S. Marshall, Giuseppe Scesa, Rachael A. Smith, Emily Rue, Jeffrey Marshall, Vince Elackattu, Monika Stoskute, Yazan Issa, Marta Santos, Duc Nguyen, Zane Hauck, Richard van Breemen, Maria S. Celej, Vadim Gaponenko, Ernesto R. Bongarzone   +15 more
doaj   +1 more source

Mesenchymal Stem Cells Inhibit Transmission of α-Synuclein by Modulating Clathrin-Mediated Endocytosis in a Parkinsonian Model

Cell Reports, 2016
Ample evidence suggests that α-synuclein is released from cells and propagated from one area of the brain to others via cell-to-cell transmission. In terms of their prion-like behavior, α-synuclein propagation plays key roles in the pathogenesis and ...
Se Hee Oh, Ha Na Kim, Hyun Jung Park, Jin Young Shin, Eun-Jin Bae, Mun Kyung Sunwoo, Seung-Jae Lee, Phil Hyu Lee   +7 more
doaj   +1 more source

Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice [PDF]

, 2012
Mutations in, or elevated dosage of, SNCA, the gene for α-synuclein (α-syn), cause familial Parkinson's disease (PD). Mouse lines overexpressing the mutant human A53Tα-syn may represent a model of early PD.
Auburger, G, Gispert, Suzana, Stephanie J Cragg, Suzana Gispert, Auburger Georg, Cragg, Stephanie J., Cragg Stephanie J., Georg Auburger, Gispert, S, Platt Nicola J., Auburger, Georg, Platt, NJ, Cragg, Stephanie, Nicola J Platt, Gispert Suzana, Platt, Nicola J.   +15 more
core   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

Neuroprotective function of Omi to α-synuclein-induced neurotoxicity

Neurobiology of Disease, 2020
Astract: The main pathological hallmark of Parkinson's disease (PD) is the presence of Lewy bodies, which mainly consist of aggregated α-synuclein. Based on the neurotoxicity of oligomeric α-synuclein and its significance in the aetiology of PD, there ...
Hea-Jong Chung, Md. Saidul Islam, Md. Mashiar Rahman, Seong-Tshool Hong   +3 more
doaj   +1 more source

Gene Correction Enhances Dopaminergic Cell Therapy in a Nonhuman Primate Model of Parkinson's Disease

Advanced Science, EarlyView.
LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan, Chongchong Xu, Jiangmei Gao, Pu Wang, Qingling Wu, Ying Jin, Binyan Lu, Mu Li, Mingting Shao, Bihai Li, Zhenghui Su, Yijng Zhang, Jianhuan Chen, Haojie An, Mengyao Huang, Xiaoji Zhuang, Yuhui Shen, Fenglin Wang, Nana Xu, Yiyan Liu, Lei Tang, Xiuling Zhong, Minyan Zhong, Jiecong Chen, Zhenhuang Wang, Xingrong Luo, Sheng Liu, RuiFeng Liu, Ling Zhang, Junhua Rao   +29 more
wiley   +1 more source

DDX39A unwinds viral RNA G-quadruplexes to limit α-Synuclein amyloidogenesis

Cell Reports
Summary: Amyloid aggregates of α-Synuclein are hallmarks of Parkinson’s disease (PD) and related neurodegenerative disorders. Literature suggests that mRNA G-quadruplexes (rG4s) bind to α-Synuclein, facilitating its amyloidogenesis.
Aanchal Jain, Shreya Tripathi, Cheshta Agarwal, Anubhab Biswas, Poojitha Sai Potharaju, Aratrika De, Shemin Mansuri, Arindam Mondal, Krishnan H. Harshan, Swasti Raychaudhuri   +9 more
doaj   +1 more source

Structural Polymorphism of polyG Inclusions Revealed by In Situ Cryo‐Electron Tomography

Advanced Science, EarlyView.
Correlative cryo‐electron tomography in primary cortical neurons and NIID mouse brain tissue reveals that polyG inclusions are interconnected ribbon‐like assemblies rather than canonical amyloid fibrils. Multiple compartment‐specific ribbon states show distinct 26S proteasome accessibility, while cytoplasmic ribbons contact and deform ER‐like ...
Yunwen Qian, Yalan Wan, Chen Chen, Xiaoyu Zheng, Wenjing Du, Junhan Yang, Zhihao Quan, Biyu Yang, Jiaxi Yu, Jie Zheng, Zhaoxia Wang, Jianwen Deng, Qiang Guo   +12 more
wiley   +1 more source

Plasma and Serum Alpha-Synuclein as a Biomarker of Diagnosis in Patients With Parkinson's Disease

Frontiers in Neurology, 2020
Background: Parkinson's disease (PD) is the second most common neurodegenerative disease, and α-synuclein plays a critical role in the pathogenesis of PD.
Chun-Wei Chang, Shieh-Yueh Yang, Che-Chuan Yang, Chia-Wen Chang, Yih-Ru Wu, Yih-Ru Wu   +5 more
doaj   +1 more source

α-Synuclein binding activity of the plant growth promoter asterubine

, 2022
Preventing the aggregation of certain amyloid proteins has the potential to slow down the progression of diseases like Alzheimer’s, Parkinson’s, and type 2 diabetes mellitus. During a high-throughput screen of 300 Australian marine invertebrate extracts,
Prebble, Dale W, Ekins, Merrick G, Hlushchuk, Irena, Mellick, George D, Er, Safak, Domanskyi, Andrii, Airavaara, Mikko, Carroll, Anthony R   +7 more
core   +1 more source