Results 91 to 100 of about 928,578 (204)

Targeting α-synuclein as possible approach to combat Parkinson's disease

, 2022
reservedLa malattia di Parkinson (PD) è una comune patologia neurodegenerativa caratterizzata da sintomi di tipo motorio e non motorio. I segni tipici di questo morbo sono la degenerazione dei neuroni dopaminergici a livello della substantia nigra pars ...
INCIARDI, ILENIA
core  

Intranasal Delivery of Gallium–Quercetin Nanoparticles for Multi‐Target Ferroptosis Inhibition in Parkinson's Disease

Advanced Science, EarlyView.
Leveraging the chemical similarity between Ga3+ and Fe3+ as well as the antioxidant properties of quercetin, gallium–quercetin nanoparticles (GQNPs) were prepared to integrate iron homeostasis regulation, oxidative stress suppression, and mitochondrial protection for multi‐target ferroptosis inhibition in Parkinson's Disease.
Keyang Xu, Dandan Kou, Xiao Xiao, Bingbing Bai, Caide Liu, Mengyao Wu, Yadan Shi, Mengdan Xu, Xiaoyi Cao, Haodi Qi, Shuhua Wu, Jianfeng Zeng, Mingyuan Gao   +12 more
wiley   +1 more source

Genetic background modifies phenotypic and transcriptional responses in a C. elegans model of α-synuclein toxicity [PDF]

, 2019
Background: Accumulation of protein aggregates are a major hallmark of progressive neurodegenerative disorders such as Parkinson’s disease and Alzheimer’s disease.
Sterken, M., Harvey, S., Stastna, J., Wang, Y., Snoek, B., Riksen, J., Kammenga, J.   +6 more
core   +1 more source

RNA Promotes Synapsin Condensates That Organize Synaptic Vesicles in Live Neurons and Enable Localized Translation in Reconstituted System

Advanced Science, EarlyView.
Condensates at synapses organize synaptic vesicles (SVs) and are crucial for efficient neurotransmitter release, yet how RNA contributes to this mesoscale architecture remains poorly understood. Here we uncover that RNA modulates synapsin–driven condensates.
Branislava Rankovic, Zachary M. Geisterfer, Akshita Chhabra, Vladimir M. Jovanovic, Ian Seim, Christian Hoffmann, Antonela Condric, Gerard Aguilar Pérez, Rinse de Boer, Lars T. Hofstede, Jingao Sun, Kiara Freitag, Katja Nowick, Marina Jendrach, Frank L. Heppner, Vladimir Despic, Michaela Müller‐McNicoll, Stephan Sigrist, Geert van den Bogaart, Sofiia Reshetniak, Amy S. Gladfelter, Dragomir Milovanovic   +21 more
wiley   +1 more source

Intracellular Catalytic Photooxygenation of α‐Synuclein Amyloid

ChemistryEurope
The amyloid aggregation of α‐synuclein is a central pathological hallmark of various synucleinopathies, including Parkinson disease. Consequently, developing strategies to eliminate α‐synuclein amyloids represents a promising therapeutic approach.
Atsushi Iwai, Youhi Hwang, Hiroki Umeda, Taka Sawazaki, Ikumi Tomizawa, Maiko Ono, Makoto Higuchi, Youhei Sohma, Yukiko Hori, Taisuke Tomita, Harunobu Mitsunuma, Motomu Kanai   +11 more
doaj   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Parkin deficiency delays motor decline and disease manifestation in a mouse model of synucleinopathy. [PDF]

, 2009
In synucleinopathies, including Parkinson's disease, partially ubiquitylated alpha-synuclein species phosphorylated on serine 129 (P(S129)-alpha-synuclein) accumulate abnormally.
Goujet-Zalc Cécile, Paleologou Katerina, Vitte Jérémie, Duchateau, René, Corti, Olga, Hamon Michel, Perez-Diaz, Fernando, Fournier Margot, Fernando Perez-Diaz, Saurini, Françoise, Traver, Sabine, Katerina Paleologou, Joubert, Chantal, Hilal A Lashuel, Christian Haass, Philipp J Kahle, Jean-Philippe Dullin, Charles Duyckaerts, Joubert Chantal, Garrigue Jérôme, Ardila-Osorio Héctor, Langui, Dominique, Michel Hamon, Jérémie Vitte, Margot Fournier, Cornilleau Fabien, Paleologou, Katerina, Duyckaerts Charles, Hanoun Naïma, Françoise Saurini, Corti Olga, Cécile Goujet-Zalc, Kahle Philipp J., Fabien Cornilleau, Haass Christian, Alexis Brice, Naïma Hanoun, Kahle, Philipp J., Cohen-Salmon, Charles, Dullin, Jean-Philippe, Fournier, Margot, Olga Corti, Hamon, Michel, Chantal Joubert, Vitte, Jérémie, René Duchateau, Cohen-Salmon Charles, Dominique Langui, Héctor Ardila-Osorio, Kahle, Philipp J, Traver Sabine, Cornilleau, Fabien, Lashuel Hilal A., Duchateau René, Jérôme Garrigue, Ardila-Osorio, Héctor, Langui Dominique, Garrigue, Jérôme, Haass, Christian, Lashuel, Hilal A., Brice Alexis, Duyckaerts, Charles, Brice, Alexis, Charles Cohen-Salmon, Perez-Diaz Fernando, Sabine Traver, Lashuel, Hilal A, Saurini Françoise, Goujet-Zalc, Cécile, Dullin Jean-Philippe, Hanoun, Naïma   +70 more
core   +3 more sources

α‐Synuclein Forms Distinct Micelle‐Like Assemblies at Low Ionic Strengths

Advanced Science, EarlyView.
At high ionic strength, α‐synuclein forms diverse assemblies, including oligomers, fibrils, and condensates. Here, we show that at low ionic strength, α‐synuclein adopts a distinct, low‐abundance assembly state. These assemblies maintain a constant size above a critical concentration and do not coalesce, suggesting a micelle‐like organization ...
Sophie Hertel, Soumik Ray, Federica Saraceno, Giacomo Nisini, Georgia Nasi, Thomas Oliver Mason, Antonin Kunka, Effrosyni Agrimaki, Dannie Juul Olesen, Francesco Simone Ruggeri, Alexander K. Buell   +10 more
wiley   +1 more source

Elevated plasma levels of alpha-synuclein are dispensable for Parkinson’s disease pathology

npj Parkinson's Disease
Although α-synuclein levels are elevated in the blood plasma of Parkinson’s disease (PD) patients, it remains unclear whether blood-derived α-synuclein directly contributes to PD.
Jin-Young Jeong, Namsuk Kim, Yan Li, Doo-Jin Kim, Hyong Kyu Kim, Won-Jong Oh   +5 more
doaj   +1 more source

Phase Separation, Material State, and Condensate Fate in Mammalian Autophagy

Advanced Science, EarlyView.
ABSTRACT Biomolecular phase separation has emerged as a key organizing principle in macroautophagy (hereafter autophagy). In mammalian cells, phase‐separated condensates not only serve as substrates for selective degradation, but also act as dynamic platforms for cargo recognition, signaling integration, and autophagosome assembly.
Yuanqiang Lin, Mingran Dai, Enyong Dai, Rui Kang, Daniel J. Klionsky, Daolin Tang, Yu Sun, Ningning Lv, Junnan Jiang   +8 more
wiley   +1 more source