Results 101 to 110 of about 928,578 (204)

Low-density lipoprotein receptor–related protein 1 mediates α-synuclein transmission from the striatum to the substantia nigra in animal models of Parkinson’s disease

Neural Regeneration Research
α-Synuclein accumulation and transmission are vital to the pathogenesis of Parkinson’s disease, although the mechanisms underlying misfolded α-synuclein accumulation and propagation have not been conclusively determined.
Hanjiang Luo, Caixia Peng, Chengli Wu, Chengwei Liu, Qinghua Li, Shun Yu, Jia Liu, Min Chen   +7 more
doaj   +1 more source

MOESM1 of CXCL12 is involved in α-synuclein-triggered neuroinflammation of Parkinson’s disease

, 2019
Additional file 1: Figure S1. Location and standardized of SN position from mouse brain. Figure S2. Levels of inflammatory factors in α-synuclein and ADM3100 treated primary microglia. Figure S3. Expression of CXCR4 in BV-2 cells. (a) Western bolt showed
Aonan Zhao (8121878), Liche Zhou (6716747), Liming Lu (505047), Xiongwei Zhu (21077), Zhichun Chen (4901431), Jun Liu (42548), Yuanyuan Li (18671), Wenyan Kang (6716756), Ningdi Luo (6716744), Mengyue Niu (4816368)   +9 more
core   +1 more source

A53T-alpha-synuclein-overexpression in the mouse nigrostriatal pathway leads to early increase of 14-3-3 epsilon and late increase of GFAP [PDF]

, 2011
Parkinson’s disease (PD) is a neurodegenerative disorder frequent at old age characterized by atrophy of the nigrostriatal projection. Overexpression and A53T-mutation of the presynaptic, vesicle-associated chaperone alpha-synuclein are known to cause ...
Oliver Schmidt, Meyer, Helmut E., Gispert, Suzana, Kurz, Alexander, May, Caroline, Helmut E. Meyer, Suzana Gispert, Marcus, Katrin, Christian Stephan, Georg Auburger, Müller, Thorsten, Auburger, Georg, Caroline May, Katrin Marcus, Alexander Kurz, Schmidt, Oliver, Thorsten Müller, Stephan, Christian   +17 more
core   +1 more source

Machine‐Learning‐Assisted Impedance Component Analysis Enables Standardizable Surface Protein Analysis of Extracellular Vesicles Using Engineered Nanovesicles

Advanced Science, EarlyView.
This study establishes a universally applicable framework for vesicle surface analysis by combining engineered amyloid‐β‐displaying nanovesicles with machine‐learning‐optimized impedance spectroscopy. Equivalent‐circuit modeling reveals that membrane capacitance correlates with the surface protein states, enabling label‐free quantification of vesicle ...
Jaeyoon Song, Neethu Ramakrishnan, Sehyeon Kim, Huiseop Lee, Youngeun Kwon, Jinsik Kim   +5 more
wiley   +1 more source

Lack of pathogenic potential of peripheral α-synuclein aggregates from Parkinson’s disease patients

Acta Neuropathologica Communications, 2018
In Parkinson’s disease (PD) there is widespread accumulation in the brain of abnormal α-synuclein aggregates forming intraneuronal Lewy bodies (LB). It is now well established that LB-type α-synuclein aggregates also occur in the peripheral autonomic ...
Ariadna Recasens, Iria Carballo-Carbajal, Annabelle Parent, Jordi Bové, Ellen Gelpi, Eduardo Tolosa, Miquel Vila   +6 more
doaj   +1 more source

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Metal Oxides Catalyze Formation of Dehydroamino Acids by Phosphate β‐Elimination Under Physiological Conditions

Angewandte Chemie, EarlyView.
Dehydroamino acids (DHAA) are atypical electrophilic sites that lead to crosslinked proteins in Alzheimer's disease (AD) brains. No catalyst for their formation has been known in humans. We report that metal oxides catalyze β‐elimination of phosphoserine and phosphothreonine in model peptides at pH 7.5°C and 37°C, yielding DHAAs.
Samuel W. Markovich, Brian L. Frey, Mark Scalf, Lloyd M. Smith   +3 more
wiley   +2 more sources

Interplay between α-synuclein, lipid membrane and DOPAC: A tripartite system against the progression of Parkinson disease

, 2022
reservedParkinson's disease (PD) is a neurodegenerative disorder associated with the degeneration of dopaminergic neurons in the substantia nigra pars-compacta. It is characterized by the presence of Lewis Bodies (LBs) inclusions.
RIZZOTTO, ELENA
core  

β-Synuclein exhibits chaperone activity more efficiently than α-synuclein [PDF]

, 2004
β-Synuclein exhibits high sequence homology and structural similarity with α-synuclein, a protein implicated in the pathogenesis of Parkinson's disease.
Choi, Kwan Yong, Lee, Daekyun, Paik, Seung R.   +2 more
core   +1 more source

Probing the Energy Landscape of α‐Synuclein Amyloid Fibril Formation by Systematic K‐to‐Q Mutagenesis

Advanced Science, EarlyView.
We use lysine‐to‐glutamine mutations to study the effect of electrostatics on the kinetics and thermodynamics of alpha‐synuclein amyloid fibril formation. We find that mutational effects map on their structural context within fibrils and identify residues that modulate the energy landscape of alpha‐synuclein self‐assembly. Our work outlines a scalable,
Antonin Kunka, Azad Farzadfard, Jacob Aunstrup Larsen, Rasmus Krogh Norrild, Federica Saraceno, Celia Fricke, Hossein Mohammad‐Beigi, Ahmed Sadek, Jonas Folke, Susana Aznar, Alexander K. Buell   +10 more
wiley   +1 more source