Results 101 to 110 of about 83,002 (289)

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

α-Synuclein interacts directly but reversibly with psychosine: implications for α-synucleinopathies

Scientific Reports, 2018
Aggregation of α-synuclein, the hallmark of α-synucleinopathies such as Parkinson’s disease, occurs in various glycosphingolipidoses. Although α-synuclein aggregation correlates with deficiencies in the lysosomal degradation of glycosphingolipids (GSL ...
Hazem Abdelkarim, Michael S. Marshall, Giuseppe Scesa, Rachael A. Smith, Emily Rue, Jeffrey Marshall, Vince Elackattu, Monika Stoskute, Yazan Issa, Marta Santos, Duc Nguyen, Zane Hauck, Richard van Breemen, Maria S. Celej, Vadim Gaponenko, Ernesto R. Bongarzone   +15 more
doaj   +1 more source

αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson’s disease [PDF]

, 2017
The etiology of Parkinson’s disease (PD) converges on a common pathogenic pathway of mitochondrial defects in which α-Synuclein (αSyn) is thought to play a role.
Alloatti, Matías, Cromberg, Lucas Eneas, Dimopoulos, Nicolás, Falzone, Tomas Luis, Marin Burgin, Antonia, Otero, Maria Gabriela, Pardi, María Belén, Pozo Devoto, Victorio Martin, Saez, Trinidad María de Los Milagros, Scassa, Maria Elida, Schinder, Alejandro Fabián, Sevlever, Gustavo, Stokin, Gorazd B.   +12 more
core   +1 more source

Optoelectrical Devices for Neural Interfacing: Engineering Integration, Stability, and Multimodal Sensing

Advanced Healthcare Materials, EarlyView.
Implantable optoelectrical devices are an effective resource for the modulation and monitoring of neural activity with high spatiotemporal resolution. This review discusses current challenges faced by these devices and outlines future perspectives for the development of next‐generation neural interfaces targeting chronic, multisite, and multimodal ...
Stella Aslanoglou, Barbara Spagnolo, Antonio Balena, Massimo De Vittorio, Ferruccio Pisanello   +4 more
wiley   +1 more source

Metabolic Investigations of the Molecular Mechanisms Associated with Parkinson's Disease. [PDF]

, 2017
Parkinson's disease (PD) is a neurodegenerative disorder characterized by fibrillar cytoplasmic aggregates of α-synuclein (i.e., Lewy bodies) and the associated loss of dopaminergic cells in the substantia nigra.
Anandhan, Annadurai, Cerny, Ronald, Dodds, Eric, Franco, Rodrigo, Huang, Yuting, Lei, Shulei, Marshall, Darrell, Panagiotidis, Mihalis, Pappa, Aglaia, Powers, Robert, Worley, Bradley   +10 more
core   +2 more sources

Designed Liquid Crystalline Nanoassemblies From Clinically Validated Polyunsaturated Lipids for Combined Antioxidant, Anti‐Apoptotic, and Neurotrophic Treatments

Advanced Healthcare Materials, EarlyView.
Ionizable lipid nanoparticles target multiple pathological pathways in neurodegeneration. The designed self‐assembled materials undergo a pH‐triggered structural transformation from a cubosome/hexosome coexistence to a hexosome phase, enhancing intracellular delivery of a multi‐target phytochemical formulation. The antioxidant‐loaded pH‐responsive LNPs
Thelma Akanchise, Fucen Luo, Borislav Angelov, Yuru Deng, Angelina Angelova   +4 more
wiley   +1 more source

Label‐Free SERS Fingerprinting of Neuroprotein Conformational Dynamics in Human Saliva

Advanced Materials, EarlyView.
Galvanic molecular entrapment (GME) is a label‐free method for detecting and quantifying neuroprotein conformational states. This technique enables direct surface binding and in situ hotspot generation around molecules, effectively overcoming challenges related to target localization and mismatched hotspot geometries.
Muhammad Shalahuddin Al Ja'farawy, Jun‐Yeong Yang, Chaewon Mun, Seunghun Lee, Chul Bum Cho, Yoo Hyun Um, Min‐Young Lee, Sung‐Gyu Park, Dong‐Ho Kim, Seung Ho Yang, Ho Sang Jung   +10 more
wiley   +1 more source

The E46K mutation modulates α-synuclein prion replication in transgenic mice

PLoS Pathogens, 2022
In multiple system atrophy (MSA), the α-synuclein protein misfolds into a self-templating prion conformation that spreads throughout the brain, leading to progressive neurodegeneration.
Sara A. M. Holec, Jisoo Lee, Abby Oehler, Lyn Batia, Aryanna Wiggins-Gamble, Jeffrey Lau, Felicia K. Ooi, Gregory E. Merz, Man Wang, Daniel A. Mordes, Steven H. Olson, Amanda L. Woerman   +11 more
doaj  

Plasma and Serum Alpha-Synuclein as a Biomarker of Diagnosis in Patients With Parkinson's Disease

Frontiers in Neurology, 2020
Background: Parkinson's disease (PD) is the second most common neurodegenerative disease, and α-synuclein plays a critical role in the pathogenesis of PD.
Chun-Wei Chang, Shieh-Yueh Yang, Che-Chuan Yang, Chia-Wen Chang, Yih-Ru Wu, Yih-Ru Wu   +5 more
doaj   +1 more source

γ-synuclein is a novel player in the control of body lipid metabolism [PDF]

, 2013
Peer reviewedPublisher ...
Buchman, Vladimir L, Millership, Steven, Ninkina, Natalia, Rochford, Justin J   +3 more
core   +1 more source