Results 41 to 50 of about 116,827 (301)
Punishment Prediction by Dopaminergic Neurons in Drosophila [PDF]
Current Biology, 2005 The temporal pairing of a neutral stimulus with a reinforcer (reward or punishment) can lead to classical conditioning, a simple form of learning in which the animal assigns a value (positive or negative) to the formerly neutral stimulus. Olfactory classical conditioning in Drosophila is a prime model for the analysis of the molecular and neuronal ...
Riemensperger, Thomas +4 more
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Molecular Medicine, 2018 Background There have been a number of reports implicating the association of microRNAs (miRs) and the MAPK signaling pathway with the dopaminergic neuron, which is involved in the development of Parkinson’s disease (PD).
Yue Dong, Li-Li Han, Zhong-Xin Xu
doaj +1 more source
eLife, 2021 Escaping aversive stimuli is essential for complex organisms, but prolonged exposure to stress leads to maladaptive learning. Stress alters neuronal activity and neuromodulatory signaling in distributed networks, modifying behavior.
Mingzheng Wu +5 more
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Task-load-dependent activation of dopaminergic midbrain areas in the absence of reward [PDF]
, 2011 Dopamine release in cortical and subcortical structures plays a central role in reward-related neural processes. Within this context, dopaminergic inputs are commonly assumed to play an activating role, facilitating behavioral and cognitive operations ...
Böhler, Nico +6 more
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Discovery of nigral dopaminergic neurogenesis in adult mice
Neural Regeneration Research, 2016 Parkinson′s disease is characterized by the loss of dopaminergic neurons in the substantia nigra. As a result, intensive efforts have focused upon mechanisms that facilitate the death of mature dopaminergic neurons. Unfortunately, these efforts have been
Brad E Morrison
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Dopaminergic Neurons Intrinsic to the Primate Striatum [PDF]
The Journal of Neuroscience, 1997 Intrinsic, striatal tyrosine hydroxylase-immunoreactive (TH-i) cells have received little consideration. In this study we have characterized these neurons and their regulatory response to nigrostriatal dopaminergic deafferentation. TH-i cells were observed in the striatum of both control and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated ...
R, Betarbet +7 more
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Acquisition of the Midbrain Dopaminergic Neuronal Identity [PDF]
International Journal of Molecular Sciences, 2020 The mesodiencephalic dopaminergic (mdDA) group of neurons comprises molecularly distinct subgroups, of which the substantia nigra (SN) and ventral tegmental area (VTA) are the best known, due to the selective degeneration of the SN during Parkinson’s disease.
Simone Mesman, Marten P. Smidt
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TDP-43 is a potential marker of dopaminergic neuronal damage caused by atrazine exposure
Ecotoxicology and Environmental Safety, 2023 Atrazine (ATR) is one of the herbicides widely used worldwide. Meanwhile, it is an environmental endocrine disruptor that can cross the blood-brain barrier and cause damage to the endocrine-nervous system, especially by affecting the normal secretion of ...
Guoliang Li +5 more
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Parkinson's Disease, 2018 Parkinson’s disease (PD) is the second most common neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra.
Minrui Weng +5 more
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Neurobiology of Disease, 2009 Toxicity of HIV-1 envelope glycoprotein (gp120) for substantia nigra (SN) neurons may contribute to the Parkinsonian manifestations often seen in HIV-1-associated dementia (HAD).
Jean-Pierre Louboutin +4 more
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