Results 21 to 30 of about 116,827 (301)

Effect of NTN and Lmx1α on the Notch Signaling Pathway during the Differentiation of Human Bone Marrow Mesenchymal Stem Cells into Dopaminergic Neuron-Like Cells

Parkinson's Disease, 2021
Human bone marrow mesenchymal stem cells (h-BMSCs) have the potential to differentiate into dopaminergic neuron-like cells to treat Parkinson’s disease.
Jinhua Zhang, Bo Yang, Lilin Luo, Linhui Li, Xuantao Yang, Juanjuan Zhang, Yuxin Xie, Wanpu Wang, Shuaiyao Lu   +8 more
doaj   +1 more source

GGC expansions in NOTCH2NLC contribute to Parkinson disease and dopaminergic neuron degeneration [PDF]

European Journal of Neurology
Xun Zhou, Qiao Xiao, Tian Tu
exaly   +2 more sources

Decreased Sirtuin Deacetylase Activity in LRRK2 G2019S iPSC-Derived Dopaminergic Neurons

Stem Cell Reports, 2017
Summary: Mitochondrial changes have long been implicated in the pathogenesis of Parkinson's disease (PD). The glycine to serine mutation (G2019S) in leucine-rich repeat kinase 2 (LRRK2) is the most common genetic cause for PD and has been shown to impair
Andrew J. Schwab, Samantha L. Sison, Michael R. Meade, Katarzyna A. Broniowska, John A. Corbett, Allison D. Ebert   +5 more
doaj   +1 more source

Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons. [PDF]

, 2017
Increased α-synuclein (αsyn) and mitochondrial dysfunction play central roles in the pathogenesis of Parkinson's disease (PD), and lowering αsyn is under intensive investigation as a therapeutic strategy for PD. Increased αsyn levels disrupt mitochondria
Bendor, Jacob T, Berthet, Amandine, Edwards, Robert H, Manfredsson, Fredric P, Nakamura, Ken, Nguyen, Mai K, Orr, Adam L, Pathak, Divya, Sellnow, Rhyomi C, Yu, Katharine   +9 more
core   +1 more source

Primary Culture of Mouse Dopaminergic Neurons [PDF]

Journal of Visualized Experiments, 2014
Dopaminergic neurons represent less than 1% of the total number of neurons in the brain. This low amount of neurons regulates important brain functions such as motor control, motivation, and working memory. Nigrostriatal dopaminergic neurons selectively degenerate in Parkinson's disease (PD).
Gaven, Florence, Marin, Philippe, Claeysen, Sylvie   +2 more
openaire   +2 more sources

Cellular mechanisms underlying burst firing in substantia nigra dopamine neurons [PDF]

, 2009
Burst firing of substantia nigra dopamine (SN DA) neurons is believed to represent an important teaching signal that instructs synaptic plasticity and associative learning.
Atherton, J.F., Bevan, M.D., Blythe, S.N., Wokosin, D.   +3 more
core   +1 more source

Transdifferentiation of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Dopaminergic Neurons in a Three-Dimensional Culture

Basic and Clinical Neuroscience, 2022
Introduction: The induction of human umbilical cord-derived mesenchymal stem cells (HUC-MSCs) toward dopaminergic neurons is a major challenge in tissue engineering and experimental and clinical treatments of various neurodegenerative diseases, including
Ardeshir Moayeri, Rafieh Alizadeh, Hatef Ghasemi Hamidabadi, Maryam Nazm Bojnordi, Ali Niapour, Azim Hedayatpour, Marzieh Darvishi, Fatemeh Heidari, Maryam Soleimani, Leila Elyasi   +9 more
doaj  

Phenotypic Reprogramming of Striatal Neurons into Dopaminergic Neuron-like Cells in the Adult Mouse Brain

Stem Cell Reports, 2018
Summary: Neuronal subtype is largely fixed in the adult mammalian brain. Here, however, we unexpectedly reveal that adult mouse striatal neurons can be reprogrammed into dopaminergic neuron-like cells (iDALs). This in vivo phenotypic reprogramming can be
Wenze Niu, Tong Zang, Lei-Lei Wang, Yuhua Zou, Chun-Li Zhang   +4 more
doaj   +1 more source

Enteric dysfunctions in experimental Parkinson's disease: alterations of excitatory cholinergic neurotransmission regulating colonic motility in rats [PDF]

, 2016
Parkinson's disease (PD) is frequently associated with gastrointestinal symptoms, mostly represented by constipation and defecatory dysfunctions.
Al Harraq, Zainab, Antonioli, Luca, Ballabeni, Vigilio, Barocelli, Elisabetta, Bernardini, Nunzia, Blandini, Fabio, Blandizzi, Corrado, Cerri, Silvia, Colucci, ROCCHINA LUCIA, Fornai, Matteo, Ippolito, Chiara, Levandis, Giovanna, Pellegrini, Carolina, Segnani, Cristina, Vegezzi, Gaia   +14 more
core   +1 more source

Cortical and Striatal Circuits in Huntington's Disease

, 2020
Huntington's disease (HD) is a hereditary neurodegenerative disorder that typically manifests in midlife with motor, cognitive, and/or psychiatric symptoms.
Blumenstock, S., Dudanova, I.
core   +1 more source