Results 21 to 30 of about 65,347 (261)

LncRNA-T199678 Mitigates α-Synuclein-Induced Dopaminergic Neuron Injury via miR-101-3p

Frontiers in Aging Neuroscience, 2020
Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by dopaminergic neuron death and the abnormal accumulation and aggregation of α-synuclein (α-Syn) in the substantia nigra (SN). Although the abnormal accumulation
Lu-Lu Bu, Lu-Lu Bu, Ying-Yu Xie, Ying-Yu Xie, Dan-Yu Lin, Ying Chen, Ying Chen, Xiu-Na Jing, Xiu-Na Jing, Yan-Ran Liang, Yan-Ran Liang, Su-Dan Peng, Su-Dan Peng, Kai-Xun Huang, En-Xiang Tao, En-Xiang Tao   +15 more
doaj   +1 more source

Selective dopaminergic vulnerability in Parkinson’s disease: new insights into the role of DAT

Frontiers in Neuroscience, 2023
One of the hallmarks of Parkinson’s disease (PD) is the progressive loss of dopaminergic neurons and associated dopamine depletion. Several mechanisms, previously considered in isolation, have been proposed to contribute to the pathophysiology of ...
Maged M. Harraz, Maged M. Harraz
doaj   +1 more source

Integrin α5β1 expression on dopaminergic neurons is involved in dopaminergic neurite outgrowth on striatal neurons [PDF]

Scientific Reports, 2017
AbstractDuring development, dopaminergic neurons born in the substantia nigra extend their axons toward the striatum. However, the mechanisms by which the dopaminergic axons extend the striatum to innervate their targets remain unclear. We previously showed that paired-cultivation of mesencephalic cells containing dopaminergic neurons with striatal ...
Izumi, Yasuhiko, Wakita, Seiko, Kanbara, Chisato, Nakai, Toshie, Akaike, Akinori, Kume, Toshiaki   +5 more
openaire   +2 more sources

An Intrinsic Neuronal Oscillator Underlies Dopaminergic Neuron Bursting [PDF]

The Journal of Neuroscience, 2009
Dopaminergic neurons of the ventral midbrain fire high-frequency bursts when animals are presented with unexpected rewards, or stimuli that predict reward. To identify the afferents that can initiate bursting and establish therapeutic strategies for diseases affected by altered bursting, a mechanistic understanding of bursting is ...
Christopher A, Deister, Mark A, Teagarden, Charles J, Wilson, Carlos A, Paladini   +3 more
openaire   +2 more sources

Suppressed microRNA-96 inhibits iNOS expression and dopaminergic neuron apoptosis through inactivating the MAPK signaling pathway by targeting CACNG5 in mice with Parkinson’s disease

Molecular Medicine, 2018
Background There have been a number of reports implicating the association of microRNAs (miRs) and the MAPK signaling pathway with the dopaminergic neuron, which is involved in the development of Parkinson’s disease (PD).
Yue Dong, Li-Li Han, Zhong-Xin Xu
doaj   +1 more source

Suppression of abnormal α-synuclein expression by activation of BDNF transcription ameliorates Parkinson’s disease-like pathology

Molecular Therapy: Nucleic Acids, 2022
Parkinson’s disease (PD) is characterized by the formation of Lewy bodies (LBs) in the brain. LBs are mainly composed of phosphorylated and aggregated α-synuclein (α-Syn).
Qianqian Cao, Shilin Luo, Wei Yao, Youge Qu, Nanbu Wang, Jian Hong, Shigeo Murayama, Zhentao Zhang, Jiaxu Chen, Kenji Hashimoto, Qi Qi, Ji-chun Zhang   +11 more
doaj   +1 more source

SARS-CoV-2 Infection Causes Dopaminergic Neuron Senescence [PDF]

Cell Stem Cell
Shuibing Chen, Liuliu Yang, Wilma D J van de Berg   +2 more
exaly   +2 more sources

Discovery of nigral dopaminergic neurogenesis in adult mice

Neural Regeneration Research, 2016
Parkinson′s disease is characterized by the loss of dopaminergic neurons in the substantia nigra. As a result, intensive efforts have focused upon mechanisms that facilitate the death of mature dopaminergic neurons. Unfortunately, these efforts have been
Brad E Morrison
doaj   +1 more source

Endogenous GDNF Is Unable to Halt Dopaminergic Injury Triggered by Microglial Activation

Cells, 2023
Overactivation of microglial cells seems to play a crucial role in the degeneration of dopaminergic neurons occurring in Parkinson’s disease. We have previously demonstrated that glial cell line-derived neurotrophic factor (GDNF) present in astrocytes ...
Julieta Mendes-Oliveira, Filipa L. Campos, Susana A. Ferreira, Diogo Tomé, Carla P. Fonseca, Graça Baltazar   +5 more
doaj   +1 more source

Dopaminergic Neurons Intrinsic to the Primate Striatum [PDF]

The Journal of Neuroscience, 1997
Intrinsic, striatal tyrosine hydroxylase-immunoreactive (TH-i) cells have received little consideration. In this study we have characterized these neurons and their regulatory response to nigrostriatal dopaminergic deafferentation. TH-i cells were observed in the striatum of both control and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated ...
R, Betarbet, R, Turner, V, Chockkan, M R, DeLong, K A, Allers, J, Walters, A I, Levey, J T, Greenamyre   +7 more
openaire   +2 more sources