Results 11 to 20 of about 65,347 (261)
Urate and its transgenic depletion modulate neuronal vulnerability in a cellular model of Parkinson's disease. [PDF]
PLoS ONE, 2012 Urate is a major antioxidant as well as the enzymatic end product of purine metabolism in humans. Higher levels correlate with a reduced risk of developing Parkinson's disease (PD) and with a slower rate of PD progression.
Sara Cipriani +5 more
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Disinhibition Bursting of Dopaminergic Neurons [PDF]
Frontiers in Systems Neuroscience, 2011 Substantia nigra pars compacta (SNpc) dopaminergic neurons receive strong tonic inputs from GABAergic neurons in the substantia nigra pars reticulata (SNpr) and globus pallidus (GP), and glutamatergic neurons in the subthalamic nucleus. The presence of these tonic inputs raises the possibility that phasic disinhibition may trigger phasic bursts in ...
Lobb, Collin J. +3 more
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Dopaminergic regulation of orexin neurons [PDF]
European Journal of Neuroscience, 2005 AbstractOrexin/hypocretin neurons in the lateral hypothalamus and adjacent perifornical area (LH/PFA) innervate midbrain dopamine (DA) neurons that project to corticolimbic sites and subserve psychostimulant‐induced locomotor activity. However, it is not known whether dopamine neurons in turn regulate the activity of orexin cells.
Bubser, Michael +5 more
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Frontiers in Cell and Developmental Biology, 2023 The generation of midbrain dopaminergic neurons (mDAs) from pluripotent stem cells (hPSC) holds much promise for both disease modelling studies and as a cell therapy for Parkinson’s disease (PD).
Shanti Sibuea +4 more
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Analytical Cellular Pathology, 2021 An increasing number of people are in a state of stress due to social and psychological pressures, which may result in mental disorders. Previous studies indicated that mesencephalic dopaminergic neurons are associated with not only reward-related ...
Shiba Niu +7 more
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Frontiers in Cellular Neuroscience, 2022 The development of dopaminergic (DA) neurons is a very complex process, and a combination of extrinsic and intrinsic factors involves their differentiation.
Reyhaneh Beiki +3 more
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Primary Culture of Mouse Dopaminergic Neurons [PDF]
Journal of Visualized Experiments, 2014 Dopaminergic neurons represent less than 1% of the total number of neurons in the brain. This low amount of neurons regulates important brain functions such as motor control, motivation, and working memory. Nigrostriatal dopaminergic neurons selectively degenerate in Parkinson's disease (PD).
Gaven, Florence +2 more
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Decreased Sirtuin Deacetylase Activity in LRRK2 G2019S iPSC-Derived Dopaminergic Neurons
Stem Cell Reports, 2017 Summary: Mitochondrial changes have long been implicated in the pathogenesis of Parkinson's disease (PD). The glycine to serine mutation (G2019S) in leucine-rich repeat kinase 2 (LRRK2) is the most common genetic cause for PD and has been shown to impair
Andrew J. Schwab +5 more
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Parkinson's Disease, 2021 Human bone marrow mesenchymal stem cells (h-BMSCs) have the potential to differentiate into dopaminergic neuron-like cells to treat Parkinson’s disease.
Jinhua Zhang +8 more
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Basic and Clinical Neuroscience, 2022 Introduction: The induction of human umbilical cord-derived mesenchymal stem cells (HUC-MSCs) toward dopaminergic neurons is a major challenge in tissue engineering and experimental and clinical treatments of various neurodegenerative diseases, including
Ardeshir Moayeri +9 more
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