Results 11 to 20 of about 116,827 (301)

Disinhibition Bursting of Dopaminergic Neurons [PDF]

Frontiers in Systems Neuroscience, 2011
Substantia nigra pars compacta (SNpc) dopaminergic neurons receive strong tonic inputs from GABAergic neurons in the substantia nigra pars reticulata (SNpr) and globus pallidus (GP), and glutamatergic neurons in the subthalamic nucleus.
Collin J Lobb, Todd W Troyer, Charles J Wilson, Carlos A Paladini   +3 more
doaj   +3 more sources

Inhibition of β-catenin dependent WNT signalling upregulates the transcriptional repressor NR0B1 and downregulates markers of an A9 phenotype in human embryonic stem cell-derived dopaminergic neurons: Implications for Parkinson's disease.

PLoS ONE, 2021
In this study we investigate how β-catenin-dependent WNT signalling impacts midbrain dopaminergic neuron (mDA) specification. mDA cultures at day 65 of differentiation responded to 25 days of the tankyrase inhibitor XAV969 (XAV, 100nM) with reduced ...
John M Haynes, Shanti M Sibuea, Alita A Aguiar, Fangwei Li, Joan K Ho, Colin W Pouton   +5 more
doaj   +1 more source

Urate and its transgenic depletion modulate neuronal vulnerability in a cellular model of Parkinson's disease. [PDF]

PLoS ONE, 2012
Urate is a major antioxidant as well as the enzymatic end product of purine metabolism in humans. Higher levels correlate with a reduced risk of developing Parkinson's disease (PD) and with a slower rate of PD progression.
Sara Cipriani, Cody A Desjardins, Thomas C Burdett, Yuehang Xu, Kui Xu, Michael A Schwarzschild   +5 more
doaj   +1 more source

SARS-CoV-2 infection causes dopaminergic neuron senescence [PDF]

Cell Stem Cell
Liuliu Yang, Shuibing Chen
exaly   +2 more sources

TGFβ3, dibutyryl cAMP and a notch inhibitor modulate phenotype late in stem cell-derived dopaminergic neuron maturation

Frontiers in Cell and Developmental Biology, 2023
The generation of midbrain dopaminergic neurons (mDAs) from pluripotent stem cells (hPSC) holds much promise for both disease modelling studies and as a cell therapy for Parkinson’s disease (PD).
Shanti Sibuea, Shanti Sibuea, Joan K. Ho, Colin W. Pouton, John M. Haynes   +4 more
doaj   +1 more source

Endoplasmic Reticulum Stress Is Associated with the Mesencephalic Dopaminergic Neuron Injury in Stressed Rats

Analytical Cellular Pathology, 2021
An increasing number of people are in a state of stress due to social and psychological pressures, which may result in mental disorders. Previous studies indicated that mesencephalic dopaminergic neurons are associated with not only reward-related ...
Shiba Niu, Weibo Shi, Yingmin Li, Shanyong Yi, Yang Li, Xia Liu, Bin Cong, Guanglong He   +7 more
doaj   +1 more source

Dopaminergic regulation of orexin neurons [PDF]

European Journal of Neuroscience, 2005
AbstractOrexin/hypocretin neurons in the lateral hypothalamus and adjacent perifornical area (LH/PFA) innervate midbrain dopamine (DA) neurons that project to corticolimbic sites and subserve psychostimulant‐induced locomotor activity. However, it is not known whether dopamine neurons in turn regulate the activity of orexin cells.
Bubser, Michael, Fadel, Jim R., Jackson, Lela L., Meador-Woodruff, James H., Jing, Deqiang, Deutch, Ariel Y.   +5 more
openaire   +3 more sources

Synergistic Effects of Combined Nurr1 Overexpression and Natural Inducers on the More Efficient Production of Dopaminergic Neuron-Like Cells From Stem Cells

Frontiers in Cellular Neuroscience, 2022
The development of dopaminergic (DA) neurons is a very complex process, and a combination of extrinsic and intrinsic factors involves their differentiation.
Reyhaneh Beiki, Mahsa Khaghani, Fariba Esmaeili, Fariba Dehghanian   +3 more
doaj   +1 more source

Deficient reinforcement learning in medial frontal cortex as a model of dopamine-related motivational deficits in ADHD [PDF]

, 2013
A
Barke, Edmund, Silvetti, Massimo, Verguts, Tom, Wiersema, Roeljan   +3 more
core   +2 more sources

Neuronal activity regulates neurotransmitter switching in the adult brain following light-induced stress. [PDF]

, 2018
Neurotransmitter switching in the adult mammalian brain occurs following photoperiod-induced stress, but the mechanism of regulation is unknown. Here, we demonstrate that elevated activity of dopaminergic neurons in the paraventricular nucleus of the ...
Deisseroth, Karl, Leutgeb, Stefan, Li, Hui-Quan, Meng, Da, Spitzer, Nicholas C   +4 more
core   +1 more source