Results 71 to 80 of about 598,888 (295)
The dopaminergic system in the aging brain of Drosophila
Frontiers in Neuroscience, 2010 Drosophila models of Parkinson’s disease are characterised by two principal phenotypes: the specific loss of dopaminergic neurons in the aging brain and defects in motor behavior.
Katherine E White +2 more
doaj +1 more source
Proteomic insights into the biology of dopaminergic neurons. [PDF]
Front Mol NeurosciDopaminergic neurons, primarily located in the substantia nigra, hypothalamus, and ventral tegmental area of the brain, play crucial roles in motor control, reward, motivation, and cognition. Alterations in their function are associated with numerous neurological and psychiatric disorders, such as Parkinson’s disease, but also Schizophrenia, substance ...
Cavarischia-Rega C +3 more
europepmc +4 more sources
Transcriptional regulation by nicotine in dopaminergic neurons [PDF]
Biochemical Pharmacology, 2013 Dopaminergic neurons in the substantia nigra pars compacta (SNc) degenerate in Parkinson's disease. These neurons robustly express several nicotinic acetylcholine receptor (nAChR) subtypes. Smoking appears to be neuroprotective for Parkinson's disease but the mechanism is unknown. To determine whether chronic nicotine-induced changes in gene expression
Henley, Beverley M. +7 more
openaire +4 more sources
Methods affecting neuronal differentiation of human adult and pluripotent stem cells [PDF]
, 2015 Stem cells have significant potential to treat many age-related degenerative disorders that affect increasing numbers of people globally. This thesis investigated the capacity for omnicytes and human pluripotent stem cells (hPSC) to undergo directed ...
Thwaites, JW
core
Parkinson Disease Subtype Stability and Eventual Convergence
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Previous research identified distinct Parkinson disease (PD) clinical subtypes of “Motor Only,” “Psychiatric & Motor,” and “Cognitive & Motor” based on comprehensive, multidomain classification. Whether these subtypes reflect distinct trajectories or progressive disease stages remains unknown.
Laura M. Rosok +10 more
wiley +1 more source
Functions of the Krüppel-like Factor 7 protein in cellular differentiation and neuronal morphogenesis [PDF]
, 2009 KLF7 is a transcription factor that is expressed during embryogenesis mostly in the nervous system and its inactivation in mice leads to perinatal lethality associated with multiple neuronal defects.
Caiazzo, Massimiliano
core +1 more source
Stem Cell Research, 2019 Parkinson's disease is associated with the loss of dopaminergic neurons in the midbrain. Clinical studies investigating replacement of these neurons with in vitro-generated neurons are currently underway.
Dominique Leitner +3 more
doaj +1 more source
Activation of CNTF/CNTFRα signaling pathway by hRheb(S16H) transduction of dopaminergic neurons in vivo. [PDF]
PLoS ONE, 2015 Ciliary neurotrophic factor (CNTF) is one of representative neurotrophic factors for the survival of dopaminergic neurons. Its effects are primarily mediated via CNTF receptor α (CNTFRα).
Kyoung Hoon Jeong +3 more
doaj +1 more source
The Role of Glutathione in Dopaminergic Neuronal Survival [PDF]
Journal of Neurochemistry, 1997 Abstract: An increased production of reactive oxygen species is thought to be critical to the pathogenesis of Parkinson's disease. At autopsy, patients with either presymptomatic or symptomatic Parkinson's disease have a decreased level of glutathione in the substantia nigra pars compacta.
K, Nakamura, W, Wang, U J, Kang
openaire +2 more sources
TOM40 Mediates Mitochondrial Dysfunction Induced by α-Synuclein Accumulation in Parkinson's Disease. [PDF]
, 2013 Alpha-synuclein (α-Syn) accumulation/aggregation and mitochondrial dysfunction play prominent roles in the pathology of Parkinson's disease. We have previously shown that postmortem human dopaminergic neurons from PD brains accumulate high levels of ...
Adame, Anthony +38 more
core +2 more sources