Results 81 to 90 of about 122,423 (305)

Direct differentiation of adult ocular progenitors into striatal dopaminergic neurons.

, 2015
Parkinson\u27s disease, characterized by motor dysfunction due to the loss of nigrostriatal dopaminergic neurons, is one of the most prevalent age-related neurodegenerative disorders.
Destache, Christopher J., Balasubramanian, S., Parameswaran, S., Rodriguez-Sierra, J., Rodriguez-Sierra, J F., Thoreson, W. B., Destache, C. J., Zhao, X., Sorrentino, John, Parameswaran, Sowmya, Balasubramanian, Sudha, Sorrentino, J., Ahmad, Iqbal, Ahmad, Hiba, Zhao, Xing, Thoreson, Wallace B., Ahmad, H., Ahmad, I.   +17 more
core   +2 more sources

Dopaminergic neurons degenerate upon UVC exposure.

, 2023
(A) Representation of damage in dopaminergic neurons after UVC exposure. 3D reconstruction of confocal fluorescence from head dopamine neurons in a pdat-1::GFP transgenic line (TG2435).
Atsushi Higashitani (350427), Kaoru Okamoto Yoshiyama (14526661), Norihiko L. Okamoto (2233519), Jun Hidema (6056015)   +3 more
core   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Effects of Forskolin on Trefoil factor 1 expression in cultured ventral mesencephalic dopaminergic neurons

, 2015
Trefoil factor 1 (TFF1) belongs to a family of secreted peptides that are mainly expressed in the gastrointestinal tract. Notably, TFF1 has been suggested to operate as a neuropeptide, however, its specific cellular expression, regulation and function ...
Jensen, Pia, Widmer, H R, Meyer, Morten, Widmer, Hans Rudolf, Meyer, M, Ducray, A D, Jensen, P, Ducray, Angélique   +7 more
core   +1 more source

Characterizing Cutaneous α‐Synuclein Deposition and Seeding Activity in Parkinson's Disease Subtypes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cutaneous phosphorylated α‐synuclein (p‐syn) and α‐synuclein seeding activity are promising biomarkers for Parkinson's disease (PD), but their clinical value remains uncertain due to disease heterogeneity. This study evaluates these two biomarkers in PD patients to inform phenotype‐specific diagnosis and disease severity assessment ...
Yuting Jin, Tianyuan Yang, Minglei Liu, Haiyang Luo, Jing Yuan, Ke Zhang, Xinsheng Han, Jing Yang, Yuming Xu   +8 more
wiley   +1 more source

Culture of human iPSC-derived dopaminergic neurons.

, 2015
(A–D) Differentiation of human iPSC-derived neural progenitor cells into dopaminergic neurons from day 0 to 14 after seeding the cells on 96-well plates at 3 × 104 cells per well. (A) day 0 (B) day 1, (C) day 7, (D) day 14. (E) Human dopaminergic neurons
Tokujiro Uchida (436598), Hiroyuki Ito (339050), Koshi Makita (436604)   +2 more
core   +1 more source

Developing a Functional Polyelectrolyte Hybrid Layer Scaffold Coating and Evaluation of Its Performance for Interaction With Neural Cells

Advanced Materials Interfaces, EarlyView.
Polyelectrolyte scaffold coatings modified with Cu and Fe3O4 nanoparticles regulate neural stem cell behavior in vitro. Increased Fe3O4 content enhances mitochondrial activity and neuronal differentiation, whereas higher Cu levels reduce cell viability.
Anna Grzeczkowicz, Agata Lipko, Angelika Kwiatkowska, Marcin Strawski, Monika Drabik, Ludomira H. Granicka   +5 more
wiley   +1 more source

Negotiating in a Foreign Land: Understanding the Curious Interactions Between Intracellular Mitochondria and Internalized Nanoparticles

Advanced Materials Interfaces, EarlyView.
Therapeutic nano‐drug delivery systems interact with cellular mitochondria in a multitude of ways. While the complexity of such interactions disrupts the mitochondrial electron transport chain and increases reactive oxygen species production, thereby contributing to nanoparticle toxicity, they also present unique theranostic opportunities in diseases ...
Sourav Bhattacharjee
wiley   +1 more source

Vitexin protects dopaminergic neurons in MPTP-induced Parkinson’s disease through PI3K/Akt signaling pathway

, 2018
Ming Hu, Fangming Li, Weidong Wang Department of Neurology, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, China Abstract: Parkinson’s disease (PD) is a progressive neurodegenerative disease which is characterized by the ...
Li F, Hu M, Wang W
core  

An Accessible Microfluidic Platform for the Generation of Polarized Brain Organoids

Advanced Materials Technologies, EarlyView.
This study presents an accessible double‐gradient microfluidic device that enables controlled morphogen delivery and spatially polarized differentiation in brain organoids. By integrating a pump‐free design and stable fabrication method, the platform generates dorsal–ventral neuronal asymmetry, offering a reproducible and versatile approach to model ...
Daniel Pérez‐Calixto, Manuel Alejandro Vazquez Valle, Mitzi Pérez‐Calixto, Cindy Peto‐Gutiérrez, Iván Velasco, Genaro Vázquez‐Victorio, Itzel Escobedo‐Avila   +6 more
wiley   +1 more source