Results 101 to 110 of about 598,888 (295)

Machine Learning‐Driven Design of Multicomponent Bone Inorganic Matrix Mimicking Scaffolds for Osteogenesis Enhanced by Neurogenesis

Advanced Science, EarlyView.
Schematic illustration of development of experimental datasets and algorithm models, screening and preparation of the scaffolds and their applications in vivo. ABSTRACT Bone defects require materials with osteogenic, neurogenic, and angiogenic activity, yet designing such materials within high‐dimensional compositional spaces remains challenging. Here,
Kunlu Lin, Ying Yang, Chuyao Zhou, Hanyue Mao, Zhiquan Zhang, Libangxi Liu, Xiaoying Yu, Haoming Liu, Long Liu, Xiaoyan Wang   +9 more
wiley   +1 more source

TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease

Advanced Science, EarlyView.
In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao, Zimeng Huang, Jianing Gao, Aolan Li, Huizhi Wang, Yingchuan Chen, Guanyu Zhu, Xin Zhang, Yin Jiang, Moxuan Zhang, Fangang Meng, Jianguo Zhang, Tingting Du   +12 more
wiley   +1 more source

Spatial and temporal distribution of dopaminergic neurons during development in zebrafish

Frontiers in Neuroanatomy, 2016
As one of the model organisms of Parkinson’s disease (PD) research, the zebrafish has its advantages, such as the 87% homology with human genome and transparent embryos which make it possible to observe the development of dopaminergic neurons in real ...
Yuchen Du, Qiang Guo, Minghui Shan, Yongmei Wu, Sizhou Huang, Haixia Zhao, Huarong Hong, Ming Yang, Xi Yang, Liyi Ren, Jiali Peng, Jing Sun, Hongli Zhou, Shurong Li, Shurong Li, Bingyin Su, Bingyin Su   +16 more
doaj   +1 more source

Necrostatin-1 protection of dopaminergic neurons

Neural Regeneration Research, 2015
Necroptosis is characterized by programmed necrotic cell death and autophagic activation and might be involved in the death process of dopaminergic neurons in Parkinson's disease. We hypothesized that necrostatin-1 could block necroptosis and give protection to dopaminergic neurons.
Jing-ru Wu, Jie Wang, Sheng-kui Zhou, Long Yang, Jia-le Yin, Jun-ping Cao, Yan-bo Cheng   +6 more
openaire   +3 more sources

The Adipose‐Sympathetic Nerve Crosstalk: FSTL1 as an Adipocyte‐Derived Neurotrophic Factor for WAT Browning

Advanced Science, EarlyView.
As a novel adipose‐derived neurotrophic factor, Follistatin‐like 1 is endocytosed by sympathetic neurons primarily via tropomyosin‐related kinase B. This process promotes sympathetic innervation in adipose tissue and norepinephrine release, leading to white adipose tissue browning, enhanced thermogenesis, and anti‐obesity effects in mice.
Xiao‐Wei Jia, Jia‐Xin Liu, Rui‐Ping Wang, Xue‐Qin Wu, Yao Che, Mu‐Chen Wu, Hong‐Wei Shang, Xin Lu, Tao Lu, Lu‐Lu Wang, Chun‐Yan Jiang, Dong‐Liang Fang, Chun Yang, Yan Gao   +13 more
wiley   +1 more source

TGF-β promotes survival on mesencephalic dopaminergic neurons in cooperation with Shh and FGF-8

Neurobiology of Disease, 2004
Impaired neuronal survival is a key event in the development of degenerative diseases, such as Parkinson's disease (PD). Here we show that transforming growth factor beta (TGF-β) acts directly on rat E14 midbrain dopaminergic neurons in vitro, its ...
Eleni Roussa, Lilla M Farkas, Kerstin Krieglstein   +2 more
doaj   +1 more source

Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend or foe?

, 2017
Exposure to psychological stress is known to seriously disrupt the operation of the substantia nigra (SN) and may in fact initiate the loss of dopaminergic neurons within the SN.
Ong, Lin Kooi, Zalewska, Katarzyna, Zhao, Zidan, Dickson, Phillip W., Walker, Frederick R., TeBay, Clifford, Nilsson, Michael, Kluge, Murielle, Johnson, Sarah J.   +8 more
core   +1 more source

The Role of Pesticide-Induced Aldehyde Dehydrogenase Inhibition in the Pathogenesis of Parkinson’s Disease [PDF]

, 2012
Parkinson’s disease (PD) is a neurodegenerative disorder particularly characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta. Its etiology is unknown but likely includes both genetic and environmental factors.
Fitzmaurice, Arthur Gerald, III
core   +1 more source

Abstract Representation of Movement Parameters in Basal Ganglia Output

Advanced Science, EarlyView.
The basal ganglia output provides a scalable velocity/position signal across behavioral contexts, supporting the idea that these variables are represented in the brain as abstract entities rather than as fixed changes in joint angles or specific sets of body effectors.
Ana Silvia Báez‐Cordero, Diana I. Ortega‐Romero, Claudia I. Pérez‐Díaz, Pavel E. Rueda‐Orozco   +3 more
wiley   +1 more source

Activity of neurochemically heterogeneous dopaminergic neurons in the substantia nigra during spontaneous and driven changes in brain state. [PDF]

, 2016
Dopaminergic neurons of the substantia nigra (SN) and ventral tegmental area (VTA) are collectively implicated in motor- and reward-related behaviors.

core   +1 more source