Results 111 to 120 of about 598,888 (295)
Advanced Science, EarlyView.Organic electrochemical transistors bridge biological ionic signaling and neuromorphic computation through volumetric electrochemical gating. This review connects Organic mixed ionic–electronic conductor materials, device architectures, and manufacturing technologies to show how geometry, ion transport, and fabrication strategies program plasticity ...
Hyunjin Lee +5 more
wiley +1 more source
Ih gene is expressed in dopaminergic neurons.
, 2012 (A) Confocal projection of adult brain showing dopaminergic neurons labeled with GFP using the Tyrosine Hydroxilase Gal4 driver (THG4;UAS:GFP). D, dorsal, L, lateral, OE, oesophagus, OL, optic lobe. (B) RT-PCR amplification of Ih (112 bp) and ple (133 bp)
Laura Torroja (166381) +5 more
core +1 more source
Advanced Science, EarlyView.Immune checkpoint inhibition (ICI) reshapes the hippocampal neuroimmune niche. Spatial transcriptomic profiling and human brain histological analyses identify neuroinflammation and altered neuronal and glial programs. Notably, T cell depletion prevents ICI‐driven microglial activation, establishing the T cell–microglia crosstalk axis as a driving ...
Devyani Swami +7 more
wiley +1 more source
Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence. [PDF]
, 2014 We found that optogenetic burst stimulation of hippocampal dopaminergic fibers from midbrain neurons in mice exploring novel environments enhanced the reactivation of pyramidal cell assemblies during subsequent sleep/rest.
Natalia Campo-Urriza +4 more
core +1 more source
PLXDC2 siRNA‐Mediated Intervention Attenuates Microglial Senescence Through cGAS‐STING Signaling
Advanced Science, EarlyView.PLXDC2 was identified as a microglial target in Parkinson's disease through human and mouse single‐cell analyses. Ferritin‐armed biomimetic nanovesicles delivered PLXDC2 siRNA, deferoxamine, and CeO2 nanoparticles across the blood–brain barrier, reducing cGAS‐STING activation, iron burden, oxidative stress, and senescence in microglia, thereby ...
Heyue Lu +13 more
wiley +1 more source
Crosstalk of parkin and Ret in dopaminergic neurons
Oncotarget, 2015 Recent genetic and functional studies have revealed striking similarities in the protein networks and molecular mechanisms altered in cancer and Parkinson's disease, as illustrated here for the converging signaling pathways of parkin and Ret [1]. These similarities may guide our thinking about potential therapies for both diseases.
openaire +2 more sources
Specific infection and destruction of dopaminergic neurons in the substantia nigra by Theiler's virus [PDF]
, 1997 Theiler's murine encephalomyelitis virus was stereotaxically inoculated unilaterally into the substantia nigra of the mouse brain. Virus specifically infected tyrosine hydroxylase-positive neurons and spread rostrocaudally throughout this subpopulation ...
Brennan, P, Oliver, K R, Fazakerley, J K
core
Differentiation of human dopaminergic neurons.
, 2014 A) hiPS cells were directed to differentiate into dopaminergic neurons. Following midbrain patterning, neural progenitor cells were manually passaged (day 16+). Dopaminergic neurons were matured for a total of 6–10 weeks before experimentation. B) RT-PCR
Sally A. Cowley (208103) +6 more
core +1 more source
Advanced Science, EarlyView.An injectable, self‐healing COPRP hydrogel integrates structurally defined oxidized Polygonati rhizoma polysaccharide with carboxymethyl chitosan through dynamic Schiff‐base crosslinking. The bioactive matrix scavenges reactive oxygen species, suppresses neuroinflammation, protects dopaminergic neurons, and supports sustained levodopa release.
Peng Dai +10 more
wiley +1 more source
eLifeOrexin signaling in the ventral tegmental area and substantia nigra promotes locomotion and reward processing, but it is not clear whether dopaminergic neurons directly mediate these effects.
Xing Xiao +6 more
doaj +1 more source