Results 121 to 130 of about 122,423 (305)

GABAergic inhibition and disinhibition of midbrain dopaminergic neurons

, 2010
This item is available only to currently enrolled UTSA students, faculty or staff. To download, navigate to Log In in the top right-hand corner of this screen, then select Log in with my UTSA ID.Midbrain dopaminergic neurons are strongly implicated in ...
Lobb, Collin J.
core  

Functionalized Biomimetic Scaffolds for Human‐Derived Auditory Neural Circuit Construction

Advanced Science, EarlyView.
In Vitro Auditory Circuit Model. ABSTRACT Damage to auditory circuits results in sensorineural hearing loss. However, the scarcity of human inner ear tissue significantly hinders the development of therapies to preserve auditory function, creating a critical need for reliable in vitro models.
Pan Feng, Qian Zhu, Yusong Wang, Hao Rong, Xu Zhang, Fuchun Wang, Tianqi Yu, Wenxuan Wang, Jing Li, Lei Tian, Menghui Liao, Renjie Chai, Yangnan Hu   +12 more
wiley   +1 more source

Deficiency of orexin receptor type 1 in dopaminergic neurons increases novelty-induced locomotion and exploration

eLife
Orexin signaling in the ventral tegmental area and substantia nigra promotes locomotion and reward processing, but it is not clear whether dopaminergic neurons directly mediate these effects.
Xing Xiao, Gagik Yeghiazaryan, Fynn Eggersmann, Anna Lena Cremer, Heiko Backes, Peter Kloppenburg, Anne Christine Hausen   +6 more
doaj   +1 more source

Automating AI Discovery for Biomedicine Through Knowledge Graphs and Large Language Models Agents

Advanced Intelligent Discovery, EarlyView.
This work proposes a novel framework that automates biomedical discovery by integrating knowledge graphs with multiagent large language models. A biologically aligned graph exploration strategy identifies hidden pathways between biomedical entities, and specialized agents use this pathway to iteratively design AI predictors and wet‐lab validation ...
Naafey Aamer, Muhammad Nabeel Asim, Shan Munir, Andreas Dengel   +3 more
wiley   +1 more source

Noradrenergic excitation of dopaminergic neurons

, 2012
This item is available only to currently enrolled UTSA students, faculty or staff. To download, navigate to Log In in the top right-hand corner of this screen, then select Log in with my UTSA ID.Dopaminergic neurons located in the ventral midbrain play a
Goertz, Richard Brandon
core  

Ets96B required in dopaminergic neurons.

, 2016
(A-C) Ets96B was knocked down throughout development (Ets96BRNAi1 or Ets96BRNAi2) specifically in dopaminergic neurons using the ple-GAL4 driver and the transcript level of genes (A) ple, (B) Vmat and (C) DAT was measured.
Mehwish Akram (2825990), Robert Fredriksson (27811), Sarah Voisin (695350), Rohit Dnyansagar (2825996), Lyle Wiemerslage (2825999), Anna Kasagiannis (2825987), Anders Eriksson (226060), Helgi B. Schiöth (152210), Sania Kheder (2825993), Valerie Ambrosi (2825984), Michael J. Williams (189446), Anica Klockars (177212), Emilie Hallqvist (2826002)   +12 more
core   +1 more source

Driver Behavior Modeling with Subjective Risk‐Driven Inverse Reinforcement Learning

Advanced Intelligent Systems, EarlyView.
A subjective risk‐driven inverse reinforcement learning framework is proposed to model driver decision‐making. It infers drivers' risk perception and risk tolerance from driving data. A learnable risk threshold is used to regulate decisions, enabling interpretable and human‐like driving behavior decisions.
Yang Liang, Zichao Wang, Zhiwei He, Qingquan Wei, Yong Zuo, Linzhen Nie, Zhishuai Yin   +6 more
wiley   +1 more source

Identification of senescence‐related genes in Parkinson's disease reveals candidate therapeutic targets and pathological processes

Animal Models and Experimental Medicine, EarlyView.
At the genomic level, a large number of differentially expressed genes (DEGs) and aging‐related DEGs have been screened. Ten hub genes, such as IFNγ and IRF7, have been identified and shown potential value in the diagnosis of PD, holding promise as novel biomarkers to facilitate early and precise diagnosis.
Haojie Wu, Tingting Liu, Xiangshu Cheng, Jianshe Wei   +3 more
wiley   +1 more source

Crosstalk of parkin and Ret in dopaminergic neurons

Oncotarget, 2015
Recent genetic and functional studies have revealed striking similarities in the protein networks and molecular mechanisms altered in cancer and Parkinson's disease, as illustrated here for the converging signaling pathways of parkin and Ret [1]. These similarities may guide our thinking about potential therapies for both diseases.
openaire   +2 more sources

Shotgun Metagenomic Profiling of the Gut Virome in Prodromal and Confirmed Parkinson's Disease

Annals of Neurology, EarlyView.
We conducted a nested case‐control study within the Nurses’ Health Study and the Health Professionals Follow‐up Study to examine the role of the gut virome (GV) in Parkinson's disease (PD). We applied a novel metagenomic virome profiling approach, Bioinformatic Application for Quantification and Labeling of Viral taxonomy (BAQLaVa), to prospectively ...
Deepika Dinesh, Xochitl C. Morgan, Jordan Jensen, Kjetil Bjornevik, Michael A. Schwarzschild, Alberto Ascherio, Curtis Huttenhower, Natalia Palacios   +7 more
wiley   +1 more source