Results 101 to 110 of about 30,228 (205)

Immunohistochemical expression of GDNF, p53 and Ki67 with TUNEL assay in canine non-neoplastic esophageal nodules induced by Spirocerca lupi

open access: yesMacedonian Veterinary Review
Spirocercosis caused by Spirocerca lupi has a global distribution and mainly infects dogs although other carnivores may be affected as well. The research aimed to ascertain the proportion of cellular proliferation/apoptosis within the parasiteinduced ...
Sara Amoorahim, Amir Amniattalab
doaj   +1 more source

Astrocyte Mechanobiology: Linking Biomechanical Forces to Biochemical Signaling in the Central Nervous System

open access: yesGlia, Volume 74, Issue 7, July 2026.
Astrocytes are key sensors and transducers of biomechanical stimuli within the central nervous system. Astrocyte development is highly dependent on mechanical stimuli such as surrounding tissue stiffness and biomechanical strain. Mechanosensory pathways including integrins, connexins and pannexins, and mechanosensitive channels regulate astrocyte ...
Ana N. Strat   +3 more
wiley   +1 more source

Human Platelet‐Derived Extracellular Vesicles Are Internalized by Human Induced Pluripotent Stem Cell‐Derived Neurons Under Control and Hypoxic Conditions

open access: yesJournal of Extracellular Biology, Volume 5, Issue 7, July 2026.
Human platelet‐derived extracellular vesicles (EVs) colocalize with cellular organelles, early endosomes and lysosomes, in neurons differentiated from human induced pluripotent stem cells, both in naïve and hypoxic conditions. Furthermore, the functional activity of neurons is changed by hypoxia and by pre‐ and post‐treatment with the EVs in hypoxic ...
Venla Harju   +4 more
wiley   +1 more source

Bridging Kidney Organoid Innovation and Regenerative Medicine: Current Advances and Future Directions

open access: yesCell Proliferation, Volume 59, Issue 7, July 2026.
This review outlines kidney organoid differentiation strategies, key developmental mechanisms, and engineering and multi‐omics approaches driving their progress toward regenerative medicine. ABSTRACT Chronic kidney disease (CKD) has emerged as a critical public health challenge worldwide, and organ donor shortages underscore the urgent need for ...
Bohong Guo   +9 more
wiley   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

open access: yesThe FEBS Journal, Volume 293, Issue 13, Page 3899-3953, July 2026.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard   +4 more
wiley   +1 more source

Parkinson's Disease Cell Transplantation Therapy: A New Dawn With Pluripotent Stem Cell–Based Therapy

open access: yesJournal of Neurochemistry, Volume 170, Issue 7, July 2026.
Parkinson's disease (PD) is characterized by the progressive loss of dopaminergic neurons in the midbrain. Cell transplantation, which aims to replace these lost neurons, has emerged as a promising approach. Early attempts using fetal ventral mesencephalic tissue showed proof‐of‐concept, with some patients achieving long‐term motor improvement. However,
Etsuro Nakanishi   +4 more
wiley   +1 more source

LRRK2 Mutation Alters Dopamine D2 Receptor Localization in Induced Pluripotent Stem Cells‐Derived Astrocytes From Parkinson's Disease Patients: Implications for Neuronal Damage

open access: yesJournal of Neurochemistry, Volume 170, Issue 7, July 2026.
In this study, human astrocytes were obtained from induced pluripotent stem cells (iPSCs) of Parkinson's disease (PD) patients carrying the G2019S LRRK2 mutation, the most common genetic cause of PD. These astrocytes display a reactive and inflammatory profile, with increased GFAP levels, elevated cytokine release, and reduced support for dopaminergic ...
Veronica Mutti   +13 more
wiley   +1 more source

Optimization of photobiomodulation therapy for spinal cord injury: A review

open access: yesPhotochemistry and Photobiology, Volume 102, Issue 4, Page 797-831, July/August 2026.
Photobiomodulation (PBM) therapy in the red and near‐infrared range can significantly modulate the secondary injury response and promote the reparative and regenerative potential of neural tissue after spinal cord injury (SCI). At present, due to the nature of delivery methods, the most effective dose and irradiance at the injury site to optimize ...
Isabella K. M. Drew   +3 more
wiley   +1 more source

Lifestyle and Clinical Predictors of Glial Cell Line-Derived Neurotrophic Factor Expression in Lumbosacral Stenosis-Related Ligamentum Flavum Degeneration

open access: yesBiomedicines
Background/Objectives: Degenerative spinal conditions, such as degenerative stenosis, have been linked to metabolic and lifestyle factors, including obesity, smoking, and diabetes.
Dawid Sobański   +8 more
doaj   +1 more source

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