Results 111 to 120 of about 37,648 (242)

UCSC screenshots of the candidate GDNF/GDNF-AS regions in dog (CanFam3 assembly) and in human (GRCh38 assembly).

, 2016
The upper panel represents the canine GDNF/GDNF-AS locus (chr4:70,8–71 Mb) with a subset of the variants identified by targeted sequencing in black and the AMS variant highlighted in green, the GDNF mRNA isoforms annotated by the BROAD institute [32] (in
David Silversides (3515558), Benoit Hédan (62240), Thomas Derrien (62244), Philippe Pilorge (3607337), Mark Samuels (77084), Christophe Hitte (2624), Manon Paradis (466273), Eric Guaguère (3607340), Nadine Botherel (3607349), Gilles Salbert (419806), Solenne Correard (3607331), Maud Bizot (3607346), Marie-Christine Cadiergues (3607328), Catherine André (2625), Jocelyn Plassais (564630), Rory Johnson (172986), Alix Pommier (3607334), Carme Arnan (3607325), Pascale Quignon (2618), Laetitia Lagoutte (465569), Agnès Méreau (3607343)   +20 more
core   +1 more source

Identification of Crucial Drug Targets and Pathways to Reprogram Drug Resistance Through Epigenetic Modulation in Advanced Lung Cancer Using Integrated Bioinformatics Approach

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Resistance to chemotherapy, which is demonstrated in almost every patient with advanced‐stage lung cancer (ALC), underscores an urgent need to unravel the underlying molecular mechanisms and identify novel strategies to overcome drug resistance. In the present study, an attempt was made to identify epigenetic targets and modulators that can be
Okibur Rahman, Mossammat Rima Akter, Nur Alam   +2 more
wiley   +1 more source

Sensor‐Detected Hypoglycaemia Is Associated With Inflammatory Protein and Immune Cell Alterations in People With Diabetes: Findings From the Hypo‐METRICS Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 12, Page 11496-11507, December 2026.
ABSTRACT Aims Experimental hypoglycaemia induces a persistent inflammatory response. We investigated whether real‐life sensor‐detected hypoglycaemia (SDH) is associated with immune parameters in people with Type 1 and Type 2 diabetes and explored potential differences between the groups.
Mandala Ajie, Namam Ali, Marijn S. Hendriksz, Patrick Divilly, Marloes J. Rietveld, Evertine J. Abbink, Pratik Choudhary, Julie Maria Bøggild Brøsen, Ulrik Pedersen‐Bjergaard, Rory J. McCrimmon, Mark Evans, Julia K. Mader, Bastiaan E. de Galan, Rinke Stienstra, Cees J. Tack, on behalf of the Hypo‐RESOLVE Consortium   +15 more
wiley   +1 more source

Endogeeninen GDNF keskiaivojen dopamiinihermosolujen säätelijänä [PDF]

, 2016
Midbrain dopamine neurons exert a powerful influence on behavior and their dysfunction is associated with many neurological and neuropsychiatric diseases, including Parkinson s disease (PD). Dopamine neurons are large, complex and sensitive cells. Hence,
Kopra, Jaakko
core  

GDNF‐Enriched Small Extracellular Vesicle‐Loaded ROS‐Scavenging Hydrogel Promotes Neural Regeneration After Spinal Cord Injury

Advanced Healthcare Materials, Volume 15, Issue 41, 6 November 2026.
A glial cell line‐derived neurotrophic factor (GDNF)‐enriched small extracellular vesicle‐loaded reactive oxygen species (ROS)‐scavenging hydrogel integrates sustained neurotrophic delivery with local modulation of oxidative and inflammatory stress after spinal cord injury. The composite hydrogel improves local vesicle retention, protects neural tissue,
Xingyu Zhu, Zhong Liu, Kewei Li, Yuhong Fan, Kangjia Yang, Xiaopeng Sun, Hang Shi, Lixuan Sun, Yang Lou, Min Wang, Peipei Wu, Hui Qian, Qiang Fu, Hua Ding   +13 more
wiley   +1 more source

Serum Insulin‐Like Growth Factor‐1 (IGF‐1) in Parkinson's Disease: A Systematic Review and Meta‐Analysis

Brain and Behavior, Volume 16, Issue 11, November 2026.
Abstract Background Parkinson's disease (PD) is a common neurodegenerative disorder characterized by progressive motor and non‐motor symptoms. Insulin‐like Growth Factor‐1 (IGF‐1), a neuroprotective hormone, has been proposed as a potential biomarker in PD. Objectives This study aimed to evaluate differences in serum IGF‐1 levels between people with PD
Sajjad Mahdavi, Shahryar Rajai Firouzabadi, Ida Mohammadi, Soroush Oraee, Mohammadreza Alinejadfard, Seyed Ali Mofidi, Mehri Salari, Ehsan Sharifipour   +7 more
wiley   +1 more source

GDNF activates transcriptional regulatory elements.

, 2018
(A) Heatmap depicting PRO-seq, H3K27ac, and H3K4me3 near 1,520 TREs uing dREG from PRO-seq data. (B) Motifs enriched in 1,036 TREs that changed following 1 hr of GDNF treatment compared with TREs that have consistent levels.
Chinatsu Mukai (406267), Scott A. Coonrod (148879), Charles G. Danko (396068), Tinyi Chu (5052032), Sachi Horibata (4051351), Edward J. Rice (4527289), Brooke A. Marks (5047733), Hui Zheng (58412)   +7 more
core   +1 more source

The Role of Astrocytes in the Inflammatory Response in Neurodiseases

MedComm, Volume 7, Issue 11, November 2026.
Reactive astrocyte‐mediated pathogenic mechanisms in neurodegenerative diseases Schematic representation of key astrocytic pathways contributing to pathology in the pathogenesis of AD, PD, ALS, and HD. In AD, astrocytes exhibit Aβ plaque‐associated activation characterized by GFAP/S100β upregulation, accompanied by impaired EAAT2‐mediated glutamate ...
Shijun Peng, Lepeng Wang, Jia Ouyang, Ruen Liu   +3 more
wiley   +1 more source

Neurodegenerative Diseases: Epidemiology, Risk Factors, Classification, Pathophysiology, Clinical Features, Diagnosis, and Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
Neurodegenerative diseases share convergent risk architectures and pathological mechanisms, yet diverge in selective vulnerability, clinical presentation, and therapeutic responsiveness. This review integrates cross‐disease epidemiology, pathophysiology, diagnosis, and treatment, highlighting the transition from symptomatic care toward biomarker‐guided
Zimeng He, Jingjing Zeng, Guoqing Wang, Yuxin Li, Feng Zhang   +4 more
wiley   +1 more source

Gastric Cancer: Epidemiology, Risk Factors, Pathogenesis, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
This comprehensive review summarizes gastric cancer epidemiology, multifactorial risk factors (like infectious, dietary, genetic), pathogenesis such as precancerous evolution, molecular alterations, and a focus on the bidirectional interactions between gastric cancer cells and macrophages in the tumor microenvironment.
Yixuan Xin, Xingya Wang, Yangtao Wu, Qian Liu, Qian Ren, Hui Wang, Jingbo Zhai   +6 more
wiley   +1 more source