Results 41 to 50 of about 37,648 (242)

Identification of mesencephalic neural stem cells overexpressing GDNF (GDNF-mNCSs).

, 2013
(A) Fluorescence photomicrographs show that all neurospheres were immunoreactive for the NSCs marker nestin. The neurospheres of peGFPN1-GDNF-transfected mNSCs (termed GDNF-mNSCs) were strong immunopositive for GDNF compare to mNSCs transfected with ...
Deqiang Lei (492095), Zhongtang Feng (492096), Ru’en Liu (492092), Xiaobin Song (492094), Jiang Long (441275), Xingli Deng (492090), Yuanxin Liang (492091), Hua Lu (240206), Yu Li (183836), Zhiyong Yang (11266), Jinkun Wang (492093)   +10 more
core   +1 more source

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing.

, 2021
RET receptor tyrosine kinase plays vital developmental and neuroprotective roles in metazoans. GDNF family ligands (GFLs) when bound to cognate GFRα co-receptors recognize and activate RET stimulating its cytoplasmic kinase function.
Annabel Borg (9332051), Svend Kjær (9181919), Aaron J Borg (8265507), Francesca M Houghton (11165451), Sarah E Adams (11165445), Andrew G Purkiss (8117213), Phillip P Knowles (9331985), David C Briggs (9556640), Andrea Nans (5176226), Christopher P Earl (9622343), Kerry M Goodman (11165448), Pauline B McIntosh (9248357), Agata Nawrotek (4433671), Neil Q McDonald (8118887)   +13 more
core  

Alterations of DNA Methylation at GDNF Gene Promoter in the Ventral Tegmental Area of Adult Depression-Like Rats Induced by Maternal Deprivation

Frontiers in Psychiatry, 2019
Objective: To study the expression and DNA methylation of the Glial cell line-derived neurotrophic factor (GDNF) gene in the development of depression-like behaviors in rats experiencing maternal deprivation stress in early life.Methods: Newborn SD rats ...
Yi Zhang, Lei Wang, Xin Wang, Yuting Wang, Yuting Wang, Chuting Li, Xiongzhao Zhu   +6 more
doaj   +1 more source

Gestational Hypoxia Disrupts Medial Ganglionic Eminence Progenitor Dynamics and Interneuron Development in Schizophrenia

Advanced Science, EarlyView.
FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni, Qiancheng Zhang, Youhui Jiang, Huiying Yao, Chuqing Zhou, Xiaoyi Tian, Shiyingnan Gao, Jun Zhao, Xinyi Ren, Naxin Xu, Mengshan Fu, Liansheng Zhao, Xueyu Qi, Xueli Yu, Wanjun Guo, Sangmi Chung, Fan Guo, Tao Li   +17 more
wiley   +1 more source

Enteric ChAT‐Expressing Neurons Mediate the Protective Effect of Lactobacillus plantarum in Inflammatory Bowel Disease

Advanced Science, EarlyView.
In colitis patients and mice, reduced Lactobacillus abundance is observed. Experimental studies show that L. plantarum A736 metabolizes dietary tryptophan into indole‐3‐lactic acid (ILA), while both L. plantarum A736 and ILA impact ChAT‐expressing enteric neurons and acetylcholine levels, thereby regulating intestinal immune responses and alleviating ...
Bing Xia, Yuwei Sun, Jialin Wang, Yike Liu, Lu Wang, Shiqi Jiang, Gaiyan Bai, Ruijing Zhang, Yu Zhang, Rongwei Kou, Danna Wang, Beita Zhao, Junjie Yi, Yu Fu, Xiaoning Liu, Xuebo Liu   +15 more
wiley   +1 more source

Differentiation of PC-12 cells cultured with MB-GDNF.

, 2013
(A) MBs without GDNF. (B) MB-GDNF. (C) Purified rat recombinant GDNF.
Yun Chen (377354), Chengyu Sun (291981), Hairong Zheng (291979), Li Liu (75607), Feng Wang (44414), Youli Cai (291978), Jie Shi (130059), Fei Yan (128878), Shukun Lu (291982), Yu Shi (117923), Lin Lu (5759), Chao Zou (291980), Xin Liu (43569)   +12 more
core   +1 more source

TRANSGENIC GDNF POSITIVELY INFLUENCES PROLIFERATION, DIFFERENTIATION, MATURATION AND SURVIVAL OF MOTOR NEURONS PRODUCED FROM MOUSE EMBRYONIC STEM CELLS.

Frontiers in Cellular Neuroscience, 2016
Embryonic stem cells (ESC) are pluripotent and thus can differentiate into every cell type present in the body. Directed differentiation into motor neurons has been described for pluripotent cells. Although neurotrophic factors promote neuronal survival,
Daniel Édgar Cortés, Daniel Édgar Cortés, Yolanda Robledo-Arratia, Ricardo Hernández-Martínez, Itzel Escobedo-Avila, Jose Bargas, Ivan Velasco, Ivan Velasco   +7 more
doaj   +1 more source

A BSCB‐Penetrating Nanoplatform for Enhanced Luteolin Delivery in PRMT2‐Targeted Epigenetic Therapy of Spinal Cord Injury

Advanced Science, EarlyView.
In this work, MSN‐BO@LUT penetrates the blood‐spinal cord barrier for luteolin delivery in spinal cord injury. The nanodrug suppresses neuroinflammation and promotes functional recovery of the spinal cord. Mechanistically, luteolin targets protein arginine N‐methyltransferase (PRMT2) to decrease toll‐like receptor 4 (TLR4) methylation, thereby ...
Yixuan Wang, Bo Jin, Shipian Li, Qianxi Ouyang, Yu Xiao, Jiaxin Wen, Yehua Lai, Ping Wang, Yongjun Wang, Xuejun Cui, Weian Zhang, Min Yao   +11 more
wiley   +1 more source

ELISA GDNF and HIRmAb-GDNF standard curves, optical density (OD) versus concentration.

, 2013
ELISA GDNF and HIRmAb-GDNF standard curves, optical density (OD) versus concentration.
Viktoriya Bondarenko (319083), Sachiko Ohshima-Hosoyama (319073), Heather A. Simmons (319075), Valerie Joers (319079), Rebecca Velotta (319085), Laura D. Wood (319087), Marina E. Emborg (319089), Nichole Goecks (319077), Christine R. Swanson (319081), Kevin Brunner (197080), Ralph H. Hruban (265335)   +10 more
core   +1 more source