Results 51 to 60 of about 7,532,121 (298)

Cross‐talk between motor neurons and myotubes via endogenously secreted neural and muscular growth factors

open access: yesPhysiological Reports, 2021
Neuromuscular junction (NMJ) research is vital to advance the understanding of neuromuscular patho‐physiology and development of novel therapies for diseases associated with NM dysfunction.
Jasdeep Saini   +8 more
doaj   +1 more source

EFFECT OF GLYPROLINES ON THE LEVEL OF APOPTOTIC AND NEUROTROPHIC FACTORS UNDER CONDITIONS OF “SOCIAL” STRESS

open access: yesФармация и фармакология (Пятигорск), 2021
The aim of the article was to study the effect of glyproline neuropeptide compounds Thr–Lys–Pro–Arg–Pro–Gly–Pro (Selank), Pro–Gly–Pro and Pro–Gly–Pro–Leu, on the level of apoptotic factors (caspase-3, caspase-8, the tumor necrosis factor) and ...
A. L. Yasenyavskaya   +5 more
doaj   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

open access: yesAdvanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu   +4 more
wiley   +1 more source

Local supplementation of FGF-2 and BDNF in the epileptogenic hippocampus. Effects and delivery strategies [PDF]

open access: yes, 2011
Among the epileptic syndromes, temporal lobe epilepsy (TLE) is the most common form in adults. It is the consequence of a brain damage (viral infection, stroke, trauma, cancer ...), capable of triggering a cascade of events culminating in the ...
Bovolenta, Roberta
core  

Biointegrated Battery‐Based Electroceuticals

open access: yesAdvanced Materials, EarlyView.
Biointegrated batteries go beyond passive power to serve as active therapeutic platforms for delivering programmable electrical cues and bioactive agents. This review examines their mechanisms and applications and provides a framework to guide battery‐based therapeutic design and clinical translation.
Yan Zhou   +6 more
wiley   +1 more source

Enhanced neurotrophic distribution, cell signaling and neuroprotection following substantia nigral versus striatal delivery of AAV2-NRTN (CERE-120)

open access: yesNeurobiology of Disease, 2013
This paper reassesses the currently accepted viewpoint that targeting the terminal fields (i.e. striatum) of degenerating nigrostriatal dopamine neurons with neurotrophic factors in Parkinson's disease (PD) is sufficient for achieving an optimal ...
Christopher D. Herzog   +7 more
doaj   +1 more source

Benefits of physical activity in neurotrophic factors [PDF]

open access: yes, 2018
This work is a review with a main objective: to develop knowledge about physical activity in neurotrophic factors. We have outlined three objectives within the affective, psychomotor and cognitive domains.
Santos, Jorge   +4 more
core   +1 more source

Bioengineered Interfaces for Peripheral Nerve Sensory Restoration

open access: yesAdvanced Materials, EarlyView.
Half of amputees abandon their prosthetics for lack of feeling. This review charts the full path from peripheral nerve injury to restored sensation, through surgical, regenerative, noninvasive, and implanted approaches, and shows how injury type and interface material properties determine which strategy can deliver naturalistic feedback, and why ...
Sydney Swedick   +4 more
wiley   +1 more source

Expression of hippocampal brain-derived neurotrophic factor and its receptors in Stanley consortium brains [PDF]

open access: yes, 2009
Several lines of evidence implicate BDNF in the pathophysiology of psychiatric illness. BDNF polymorphisms have also been associated with the risk of schizophrenia and mood disorders.
Dunham, Jason S.   +12 more
core   +1 more source

Bottom‐Up Engineering of a Human Neuromuscular System for Modeling Activity‐Induced Remodeling, Metabolic Stress, and Endothelial‐Modulated Excitability

open access: yesAdvanced Materials, EarlyView.
Using a bottom‐up approach, we engineered a human neuromuscular microchip to investigate distinct adaptive responses to neural stimulation and metabolic stress. Further integration of endothelial cells revealed their critical role in modulating neuromuscular excitability, establishing a comprehensive neurovascular‐muscular model.
Jinchul Ahn   +17 more
wiley   +1 more source

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