Results 31 to 40 of about 7,894,191 (193)

Absence of Ret signaling in mice causes progressive and late degeneration of the nigrostriatal system [PDF]

, 2007
Support of ageing neurons by endogenous neurotrophic factors such as glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) may determine whether the neurons resist or succumb to neurodegeneration.
Aron, Liviu, Edgar R Kramer, Zhuang, Xiaoxi, Klein, R., Klaus Beyer, Geert M J Ramakers, Smidt, Marten P., Kramer, E., Ramakers, Geert M. J., Klein, Rüdiger, Beyer, K., Seitz, S., Marten P Smidt, Ramakers, G., Xiaoxi Zhuang, Beyer, Klaus, Zhuang, X., Liviu Aron, Sabine Seitz, Rüdiger Klein, Smidt, M., Seitz, Sabine, Kramer, Edgar R., Aron, L., Kramer Edgar R, Ramakers, Geert M. J, Smidt Marten P, Ramakers Geert M. J, Seitz Sabine, Aron Liviu, Zhuang Xiaoxi, Beyer Klaus, Klein Rüdiger   +32 more
core   +2 more sources

AMSCs secreted neurotrophic factors in vitro.

, 2022
The ability of AMSCs to secrete trophic factors was evaluated using ELISA. Neurotrophic factors such as (A) BDNF, (B) VEGF, and (C) b-FGF were significantly secreted from AMSCs compared with the control medium.
Sho Yamaguchi (5309186), Shunsuke Ohnishi (167269), Masahito Kawabori (13021466), Kazuyoshi Yamazaki (7387250), Toshitaka Seki (13021472), Kotaro Konno (534026), Khin Khin Tha (13021475), Miki Fujimura (7244756), Koji Yamamoto (505190), Soichiro Takamiya (13021463), Kiyohiro Houkin (562861), Aki Tanimori (13021469), Daigo Hashimoto (13021478), Masahiko Watanabe (47746)   +13 more
core   +1 more source

Neurotrophic factors in the testis [PDF]

, 1999
Neurotrophic factors, interacting with neurons to affect their growth, are a subset of the polypeptide growth factors. There is increasing evidence for a broader physiological role of these factors which includes effects on a variety of nonneuronal ...
Davidoff, Michail S.; University of Hamburg, Mutter, Dieter; University of Hamburg, Middendorff, Ralf; University of Hamburg   +2 more
core   +1 more source

Collagen scaffold loaded allogeneic neural stem cells promoted locomotion recovery of spinal cord injury mainly through secreting neurotrophic factors

Materials & Design, 2022
The combination of biological scaffold and neural stem cells (NSCs) is a promising treatment strategy for spinal cord injury (SCI). But adverse niche at injures spinal cord severe hamper the transplanted NSCs to preferentially differentiate neurons.
Shuo Liu, Caixia Fan, Yuanyuan Xie, Liudi Wang, Yanyan Cui, Bin Wang   +5 more
doaj   +1 more source

A Neurotrophic Model of the Development of the Retinogeniculocortical Pathway Induced by Spontaneous Retinal Waves

, 1999
The development of the retinogeniculate pathway or the geniculocortical pathway, or both, occurs either before birth or before eye opening in many species.
Shadbolt, N. R, Terry Elliott, Elliott, T, Nigel R. Shadbolt   +3 more
core   +2 more sources

Neurotrophins and Other Growth Factors in the Pathogenesis of Alzheimer’s Disease

Life, 2023
The involvement of the changed expression/function of neurotrophic factors in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (AD), has been suggested.
Tadahiro Numakawa, Ryutaro Kajihara
doaj   +1 more source

Neurotrophic factor-based pharmacological approaches in neurological disorders

Neural Regeneration Research, 2023
Aging is a physiological event dependent on multiple pathways that are linked to lifespan and processes leading to cognitive decline. This process represents the major risk factor for aging-related diseases such as Alzheimer’s disease, Parkinson’s ...
Margherita Alfonsetti, Michele d’Angelo, Vanessa Castelli   +2 more
doaj   +1 more source

Neurotrophic factors in tension-type headache

Arquivos de Neuro-Psiquiatria, 2015
Neurotrophic factors (NF) are involved in pain regulation and a few studies have suggested that they may play a pathophysiological role in primary headaches. The aim of this study was to investigate NF levels in patients with tension type headache (TTH).
Renan B. Domingues, Halina Duarte, Natália P. Rocha, Antonio L. Teixeira   +3 more
doaj   +1 more source

Brain-Derived Neurotrophic Factor and Nerve Growth Factor Therapeutics for Brain Injury: The Current Translational Challenges in Preclinical and Clinical Research

Neural Plasticity, 2022
Ischemic stroke and traumatic brain injury (TBI) are among the leading causes of death and disability worldwide with impairments ranging from mild to severe.
Serena-Kaye Sims, Brynna Wilken-Resman, Crystal J. Smith, Ashley Mitchell, Lilly McGonegal, Catrina Sims-Robinson   +5 more
doaj   +1 more source

Neurotrophic signaling in liver cancers: mechanisms and potential therapeutic targets [PDF]

Exploration of Digestive Diseases
Recent studies demonstrate that peripheral innervation and Schwann cells (SCs) activity within the tumor microenvironment (TME) have a significant influence on liver cancer, specifically hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (
Lorenzo Mainardi, Fabio Marra, Chiara Raggi   +2 more
doaj   +1 more source