Results 71 to 80 of about 7,532,121 (298)

Enlarged infarct volume and loss of BDNF mRNA induction following brain ischemia in mice lacking FGF-2 [PDF]

, 2006
FGF-2, a potent multifunctional and neurotrophic growth factor, is widely expressed in the brain and upregulated in cerebral ischemia. Previous studies have shown that intraventricularly or systemically administered FGF-2 reduces the size of cerebral ...
Kiprianova, Irina, Dono, Rosanna, Schindowski, Katharina, Krause, Sonja, Bohlen und Halbach, Oliver von, Schwaninger, Markus, Unsicker, Klaus   +6 more
core   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Pharmacology Of Neurotrophic Factors

, 2019
Neurotrophic factors (NTFs) are a relevant group of secreted proteins that modulate growth, differentiation, repair and survival of neurons. During development, NTFs prevent apoptosis and regulate the number of neurons innervating target tissues, in ...
Chebli, Ali
core  

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source

Neurotrophic factors and neuropathic pain

, 2001
Neuropathic pain is a debilitating consequence of nerve damage. Existing treatment is largely ineffective. Current models of neuropathic pain recognise the importance of ectopic activity in primary sensory neurones impinging on a sensitised central ...
Boucher, T J, McMahon, S B
core   +1 more source

Trophic and neurotrophic factors in human pituitary adenomas (Review) [PDF]

, 2017
The pituitary gland is an organ that functionally connects the hypothalamus with the peripheral organs. The pituitary gland is an important regulator of body homeostasis during development, stress, and other processes.
Taurone S., Altissimi G., Parnigotto, Pier Paolo, Mario Tombolini, Lia Bardella, Tombolini, Mario, Wierzbicki V., Spoletini, M, Enzo Agostinelli, Bardella L., Giangaspero F., Agostinelli, Enzo, Tombolini M., Agostinelli E., Felice Giangaspero, Pastore F. S., Taurone, Samanta, Altissimi, Giancarlo, Giangaspero, F, Artico, Marco, Wierzbicki, V, Pastore, Francesco Saverio, Tombolini, M, Marialuisa Spoletini, Spoletini, Marialuisa, Minni, A, Minni, Antonio, Giancarlo Altissimi, Pastore, FS, Bardella, Lia, Artico M., Pier Paolo Parnigotto, Venceslao Wierzbicki, Samanta Taurone, Parnigotto, PP, Antonio Minni, Artico, M, Altissimi, G, Parnigotto P. P., Bardella, L, Spoletini M., Wierzbicki, Venceslao, Agostinelli, E, Marco Artico, Francesco Saverio Pastore, Giangaspero, Felice, Minni A., Taurone, S   +47 more
core   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Diversity of Microglia-Derived Molecules with Neurotrophic Properties That Support Neurons in the Central Nervous System and Other Tissues

Molecules
Microglia, the brain immune cells, support neurons by producing several established neurotrophic molecules including glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF).
Kennedy R. Wiens, Naved Wasti, Omar Orlando Ulloa, Andis Klegeris   +3 more
doaj   +1 more source

High-Intensity Interval Exercise Regulates Neurotrophic Factors and Astrocyte Activity in the Hippocampus and Cerebral Cortex [PDF]

운동과학
PURPOSE Exercise training is widely recognized as a complementary intervention that provides both therapeutic and preventive benefits for neurodegenerative diseases, given its strong association with brain health.
Junyoung Hong, Seon-Hee Kim, Jiyeon Kim, Chang Sun Kim, Dong-Ho Park, Hye Jung Kim, Sang Won Park, Jong-Won Kim, Young Hyun Jung, Seung Pil Yun   +9 more
doaj   +1 more source

Impact of neurotrophic factors combination therapy on retinitis pigmentosa

Journal of International Medical Research, 2020
Objective We aimed to determine the location of neurotrophic receptors tropomyosin receptor kinase (Trk)B, TrkC, and ciliary neurotrophic factor receptor (CNTFR)α in the retina of retinal degeneration ( rd ) mice and to explore the dynamic changes of B ...
Xiaobei Yin, Ting He, Rui Chen, Hui Cui, Genlin Li   +4 more
doaj   +1 more source