Results 1 to 10 of about 229,240 (269)
Neuroprotective effects of zonisamide on cerebral ischemia injury via inhibition of neuronal apoptosis [PDF]
Brazilian Journal of Medical and Biological Research, 2021 It is known that neuronal apoptosis contributes to pathology of cerebral ischemia injury. Zonisamide (ZNS) has shown anti-apoptosis effects in recent studies.
Junna He +6 more
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Journal of Neuroinflammation, 2021 Background It is suggested that neuroinflammation, in which activated microglial cells play a relevant role, contributes to the development of Parkinson’s disease (PD).
Neus Rabaneda-Lombarte +5 more
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npj Parkinson's Disease, 2022 Neuroinflammation, in which activated microglia are involved, appears to contribute to the development of Parkinson’s disease (PD). However, the role of microglial activation and the mechanisms governing this process remain uncertain.
Neus Rabaneda-Lombarte +8 more
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Thrombolysis for Cerebral Ischemia [PDF]
Frontiers in Neurology, 2010 The care for patients with acute ischemic stroke has been revolutionized by the clinical application of fibrinolysis. Intravenous recombinant tissue plasminogen activator (rt-PA) has been proven to improve functional outcomes following acute ischemic stroke and can be administered to a select group of patients up to 4.5 h after symptom onset. Time from
Fugate, Jennifer E. +2 more
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Effects and Mechanisms of Exosomes from Different Sources in Cerebral Ischemia
Cells, 2022 Cerebral ischemia refers to the symptom of insufficient blood supply to the brain. Cells of many different origins participate in the process of repairing damage after cerebral ischemia occurs, in which exosomes secreted by the cells play important roles.
Ruoxi Xie +4 more
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The transcriptome of cerebral ischemia [PDF]
Brain Research Bulletin, 2012 The molecular causality and response to stroke is complex. Yet, much of the literature examining the molecular response to stroke has focused on targeted pathways that have been well-characterized. Consequently, our understanding of stroke pathophysiology has made little progress by way of clinical therapeutics since tissue plasminogen activator was ...
Reyna L, VanGilder +3 more
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The Alterations in Mitochondrial Dynamics Following Cerebral Ischemia/Reperfusion Injury
Antioxidants, 2021 Cerebral ischemia results in a poor oxygen supply and cerebral infarction. Reperfusion to the ischemic area is the best therapeutic approach. Although reperfusion after ischemia has beneficial effects, it also causes ischemia/reperfusion (I/R) injury ...
Jirapong Vongsfak +5 more
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Sirt1 in cerebral ischemia [PDF]
Brain Circulation, 2015 Cerebral ischemia is among the leading causes of death worldwide. It is characterized by a lack of blood flow to the brain that results in cell death and damage, ultimately causing motor, sensory, and cognitive impairments. Today, clinical treatment of cerebral ischemia, mostly stroke and cardiac arrest, is limited and new neuroprotective therapies are
Kevin B Koronowski +1 more
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Journal of Medical Science, 2021 Aim. Measure of the histological changes in neurons in the parietal cortex and hippocampus of rats with partial, subtotal, stepwise subtotal, and total cerebral ischemia. Material and Methods. Studies were performed on 84 rats. Partial cerebral ischemia
Lizaveta I. Bon, Nataliya Y. Maksimovich
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Establishment and Evaluation of a Monkey Acute Cerebral Ischemia Model [PDF]
Clinics, 2020 OBJECTIVES: Cerebral ischemia seriously threatens human health and is characterized by high rates of incidence, disability and death. Developing an ideal animal model of cerebral ischemia that reflects the human clinical features is critical for ...
Li Yan +11 more
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