Results 1 to 10 of about 772,922 (307)
MicroRNAs in Cerebral Ischemia [PDF]
Stroke Research and Treatment, 2013 The risk of ischemic stroke increases substantially with age, making it the third leading cause of death and the leading cause of long-term disability in the world. Numerous studies demonstrated that genes, RNAs, and proteins are involved in the occurrence and development of stroke. Current studies found that microRNAs (miRNAs or miRs) are also closely
Yang Wang, Yongting Wang, Guo-Yuan Yang
openaire +3 more sources
Neural Regeneration Research, 2015 Cell therapy using stem cell transplantation against cerebral ischemia has been reported. However, it remains controversial regarding the optimal time for cell transplantation and the transplantation route.
Seyed Mojtaba Hosseini +4 more
doaj +1 more source
microRNA-455-5p alleviates neuroinflammation in cerebral ischemia/reperfusion injury
Neural Regeneration Research, 2022 Neuroinflammation is a major pathophysiological factor that results in the development of brain injury after cerebral ischemia/reperfusion. Downregulation of microRNA (miR)-455-5p after ischemic stroke has been considered a potential biomarker and ...
Jian-Song Zhang +10 more
doaj +1 more source
CaMKII in cerebral ischemia [PDF]
Acta Pharmacologica Sinica, 2011 Ischemic insults on neurons trigger excessive, pathological glutamate release that causes Ca²⁺ overload resulting in neuronal cell death (excitotoxicity). The Ca²⁺/calmodulin (CaM)-dependent protein kinase II (CaMKII) is a major mediator of physiological excitatory glutamate signals underlying neuronal plasticity and learning. Glutamate stimuli trigger
Steven J, Coultrap +4 more
openaire +2 more sources
MicroRNA-670 aggravates cerebral ischemia/reperfusion injury via the Yap pathway
Neural Regeneration Research, 2021 Apoptosis is an important programmed cell death process involved in ischemia/reperfusion injury. MicroRNAs are considered to play an important role in the molecular mechanism underlying the regulation of cerebral ischemia and reperfusion injury. However,
Shi-Jia Yu +4 more
doaj +1 more source
Neural Regeneration Research, 2017 Ischemic preconditioning elicited by a non-fatal brief occlusion of blood flow has been applied for an experimental therapeutic strategy against a subsequent fatal ischemic insult.
In Hye Kim +12 more
doaj +1 more source
Neuroprotective Effect of Physical Activity in Ischemic Stroke: Focus on the Neurovascular Unit
Frontiers in Cellular Neuroscience, 2022 Cerebral ischemia is one of the major diseases associated with death or disability among patients. To date, there is a lack of effective treatments, with the exception of thrombolytic therapy that can be administered during the acute phase of ischemic ...
Hui Zhang, Qi Xie, Juan Hu
doaj +1 more source
Pathophysiology of Cerebral Ischemia
Neurologia medico-chirurgica, 1998 The purpose of this manuscript is to briefly review the pathophysiology of cerebral ischemia. Ischemic thresholds are well-defined in lower animals. The concept of the ischemic penumbra may include regions of brain around deeper regions of ischemia but has also been defined in terms of brain salvageable by reperfusion or by pharmacological therapies ...
MACDONALD, R. Loch, STOODLEY, Marcus
openaire +2 more sources
Epigenetic Mechanisms in Cerebral Ischemia [PDF]
Journal of Cerebral Blood Flow & Metabolism, 2013 Treatment efficacy for ischemic stroke represents a major challenge. Despite fundamental advances in the understanding of stroke etiology, therapeutic options to improve functional recovery remain limited. However, growing knowledge in the field of epigenetics has dramatically changed our understanding of gene regulation in the last few decades ...
Schweizer, Sophie +2 more
openaire +2 more sources
Cav3.2 channel regulates cerebral ischemia/reperfusion injury: a promising target for intervention
Neural Regeneration ResearchCalcium influx into neurons triggers neuronal death during cerebral ischemia/reperfusion injury. Various calcium channels are involved in cerebral ischemia/reperfusion injury. Cav3.2 channel is a main subtype of T-type calcium channels.
Feibiao Dai +9 more
doaj +1 more source