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Traumatic brain ischemia during neuro intensive care: myth rather than fact [PDF]

Arquivos de Neuro-Psiquiatria, 2001
In non-missile severe acute brain trauma, brain ischemia was a frequent finding in cadavers. Studies during neuro intensive care, however, have failed to disclose brain ischemia under most circumstances, except when cerebral hemodynamic and metabolic ...
Julio Cruz
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Hypoxia–ischemia in the immature brain [PDF]

Journal of Experimental Biology, 2004
SUMMARYThe immature brain has long been considered to be resistant to the damaging effects of hypoxia and hypoxia–ischemia (H/I). However, it is now appreciated that there are specific periods of increased vulnerability, which relate to the developmental stage at the time of the insult.
Susan J, Vannucci, Henrik, Hagberg
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Neutralizing anti-interleukin-1β antibodies modulate fetal blood–brain barrier function after ischemia

Neurobiology of Disease, 2015
We have previously shown that increases in blood–brain barrier permeability represent an important component of ischemia–reperfusion related brain injury in the fetus.
Xiaodi Chen, Grazyna B. Sadowska, Jiyong Zhang, Jeong-Eun Kim, Erin E. Cummings, Courtney A. Bodge, Yow-Pin Lim, Oleksandr Makeyev, Walter G. Besio, John Gaitanis, Steven W. Threlkeld, William A. Banks, Barbara S. Stonestreet   +12 more
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Pyrrolidine dithiocarbamate attenuates brain Aβ increase and improves long-term neurological outcome in rats after transient focal brain ischemia

Neurobiology of Disease, 2012
Evidence suggests an association between brain ischemia and Alzheimer's disease (AD) development. Amyloid plaques consisted of β-amyloid peptide (Aβ) in the brain are a pathological hallmark of AD. Little is known about how brain ischemia induces AD-like
Jiejie Li, Wenli Sheng, Chenzhuo Feng, Zhiyi Zuo   +3 more
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Brain tissue responses to ischemia [PDF]

Journal of Clinical Investigation, 2000
The brain is particularly vulnerable to ischemia. Complete interruption of blood flow to the brain for only 5 minutes triggers the death of vulnerable neurons in several brain regions, whereas 20–40 minutes of ischemia is required to kill cardiac myocytes or kidney cells.
J M, Lee, M C, Grabb, G J, Zipfel, D W, Choi   +3 more
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Populus tomentiglandulosa Extract Is Rich in Polyphenols and Protects Neurons, Astrocytes, and the Blood-Brain Barrier in Gerbil Striatum Following Ischemia-Reperfusion Injury

Molecules, 2021
Transient ischemia in brains causes neuronal damage, gliosis, and blood–brain barrier (BBB) breakdown, which is related to ischemia-induced brain dysfunction.
Tae-Kyeong Lee, Jae-Chul Lee, Jong-Dai Kim, Dae-Won Kim, Ji-Hyeon Ahn, Joon-Ha Park, Hyung-Il Kim, Jun-Hwi Cho, Soo-Young Choi, Moo-Ho Won, II-Jun Kang   +10 more
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Protective Action of Indapamide, a Thiazide-Like Diuretic, on Ischemia-Induced Injury and Barrier Dysfunction in Mouse Brain Microvascular Endothelial Cells

Journal of Pharmacological Sciences, 2007
The aim of the present study was to elucidate the effects of indapamide on ischemic damage to the blood-brain barrier (BBB) in vitro. The ischemia /reperfusion conditions employed here significantly decreased the viability of mouse brain capillary ...
Tsuyoshi Nishioku, Fuyuko Takata, Atsushi Yamauchi, Noriko Sumi, Ikumi Yamamoto, Akiko Fujino, Mikihiko Naito, Takashi Tsuruo, Hideki Shuto, Yasufumi Kataoka   +9 more
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Single-cell RNA sequencing unveils Lrg1's role in cerebral ischemia‒reperfusion injury by modulating various cells

Journal of Neuroinflammation, 2023
Background and purpose Cerebral ischemia‒reperfusion injury causes significant harm to human health and is a major contributor to stroke-related deaths worldwide. Current treatments are limited, and new, more effective prevention and treatment strategies
Zhaohui Ruan, Guosheng Cao, Yisong Qian, Longsheng Fu, Jinfang Hu, Tiantian Xu, Yaoqi Wu, Yanni Lv   +7 more
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The role of glycogen synthase kinase 3 beta in brain injury induced by myocardial ischemia/reperfusion injury in a rat model of diabetes mellitus

Neural Regeneration Research, 2017
Myocardial ischemia/reperfusion injury can lead to severe brain injury. Glycogen synthase kinase 3 beta is known to be involved in myo-cardial ischemia/reperfusion injury and diabetes mellitus. However, the precise role of glycogen synthase kinase 3 beta
Bo Zhao, Wen-wei Gao, Ya-jing Liu, Meng Jiang, Lian Liu, Quan Yuan, Jia-bao Hou, Zhong-yuan Xia   +7 more
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Quantitative EEG for the detection of brain ischemia [PDF]

Critical Care, 2012
Monitoring in most intensive care units (ICUs) is limited to continuous assessments of cardiopulmonary function, whereas brain monitoring has traditionally been limited to serial neurological examinations and infrequent imaging studies. Increasingly it is becoming clear that secondary neurological complications, such as seizures and brain ischemia, are
Foreman, Brandon, Claassen, Jan
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