Results 11 to 20 of about 359,925 (305)

CNS-border associated macrophages respond to acute ischemic stroke attracting granulocytes and promoting vascular leakage

open access: yesActa Neuropathologica Communications, 2018
The central nervous system (CNS) contains several types of immune cells located in specific anatomic compartments. Macrophages reside at the CNS borders surrounding the brain vessels, in leptomeningeal spaces and the choroid plexus, where they interact ...
Jordi Pedragosa   +13 more
doaj   +1 more source

Wide therapeutic time window for nimesulide neuroprotection in a model of transient focal cerebral ischemia in the rat [PDF]

open access: yes, 2004
Results from several studies indicate that cyclooxygenase-2 (COX-2) is involved ischemic brain injury. The purpose of this study was to evaluate the neuroprotective effects of the selective COX-2 inhibitor nimesulide on cerebral infarction and ...
Candelario-Jalil, Eduardo   +4 more
core   +1 more source

Metabolism of biogenic amines in acute cerebral ischemia: Influence of systemic hyperglycemia [PDF]

open access: yesActa Veterinaria, 2012
Dopamine, norepinephrine and serotonin are biogenic amines which are transmitters of the central nervous system. The effects of ischemia on the brain parenchyma depends on many factors, such is the mechanism of blood flow interruption, velocity of the
Milovanović Aleksandar   +7 more
doaj   +1 more source

Protective Effect of Adenosine A2B Receptor Agonist, BAY60-6583, Against Transient Focal Brain Ischemia in Rat

open access: yesFrontiers in Pharmacology, 2021
Cerebral ischemia is a multifactorial pathology characterized first by an acute injury, due to excitotoxicity, followed by a secondary brain injury that develops hours to days after ischemia.
Ilaria Dettori   +8 more
doaj   +1 more source

Barrier mechanisms in neonatal stroke. [PDF]

open access: yes, 2014
Clinical data continue to reveal that the incidence of perinatal stroke is high, similar to that in the elderly. Perinatal stroke leads to significant morbidity and severe long-term neurological and cognitive deficits, including cerebral palsy ...
Chip, Sophorn   +2 more
core   +2 more sources

Parkinsonian Neurotoxins Impair the Pro-inflammatory Response of Glial Cells

open access: yesFrontiers in Molecular Neuroscience, 2019
In the case of Parkinson’s disease (PD), epidemiological studies have reported that pesticide exposure is a risk factor for its pathology. It has been suggested that some chemical agents, such as rotenone and paraquat, that inhibit the mitochondrial ...
Neus Rabaneda-Lombarte   +5 more
doaj   +1 more source

Transplantation of human neural stem/progenitor cells overexpressing galectin-1 improves functional recovery from focal brain ischemia in the mongolian gerbil

open access: yesMolecular Brain, 2011
Transplantation of human neural stem/progenitor cells (hNSPCs) is a promising method to regenerate tissue from damage and recover function in various neurological diseases including brain ischemia.
Yamane Junichi   +10 more
doaj   +1 more source

Effects and Mechanisms of Exosomes from Different Sources in Cerebral Ischemia

open access: yesCells, 2022
Cerebral ischemia refers to the symptom of insufficient blood supply to the brain. Cells of many different origins participate in the process of repairing damage after cerebral ischemia occurs, in which exosomes secreted by the cells play important roles.
Ruoxi Xie   +4 more
doaj   +1 more source

Review on herbal medicine on brain ischemia and reperfusion

open access: yesAsian Pacific Journal of Tropical Biomedicine, 2015
Brain ischemia and reperfusion is the leading cause of serious and long-range disability in the world. Clinically significant changes in central nervous system function are observed following brain ischemia and reperfusion.
Nahid Jivad, Zahra Rabiei
doaj   +1 more source

Ischemic postconditioning protects against ischemic brain injury by up-regulation of acid-sensing ion channel 2a

open access: yesNeural Regeneration Research, 2016
Ischemic postconditioning renders brain tissue tolerant to brain ischemia, thereby alleviating ischemic brain injury. However, the exact mechanism of action is still unclear.
Wang-sheng Duanmu   +5 more
doaj   +1 more source

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