Results 21 to 30 of about 216,705 (266)

Hyperglycemia and Focal Brain Ischemia [PDF]

Journal of Cerebral Blood Flow & Metabolism, 1999
The influence of hyperglycemic ischemia on tissue damage and cerebral blood flow was studied in rats subjected to short-lasting transient middle cerebral artery (MCA) occlusion. Rats were made hyperglycemic by intravenous infusion of glucose to a blood glucose level of about 20 mmol/L, and MCA occlusion was performed with the ...
L, Gisselsson, M L, Smith, B K, Siesjö
openaire   +2 more sources

Hypoxia–ischemia in the immature brain [PDF]

Journal of Experimental Biology, 2004
SUMMARYThe immature brain has long been considered to be resistant to the damaging effects of hypoxia and hypoxia–ischemia (H/I). However, it is now appreciated that there are specific periods of increased vulnerability, which relate to the developmental stage at the time of the insult.
Susan J, Vannucci, Henrik, Hagberg
openaire   +2 more sources

Neutralizing anti-interleukin-1β antibodies modulate fetal blood–brain barrier function after ischemia

Neurobiology of Disease, 2015
We have previously shown that increases in blood–brain barrier permeability represent an important component of ischemia–reperfusion related brain injury in the fetus.
Xiaodi Chen, Grazyna B. Sadowska, Jiyong Zhang, Jeong-Eun Kim, Erin E. Cummings, Courtney A. Bodge, Yow-Pin Lim, Oleksandr Makeyev, Walter G. Besio, John Gaitanis, Steven W. Threlkeld, William A. Banks, Barbara S. Stonestreet   +12 more
doaj   +1 more source

Populus tomentiglandulosa Extract Is Rich in Polyphenols and Protects Neurons, Astrocytes, and the Blood-Brain Barrier in Gerbil Striatum Following Ischemia-Reperfusion Injury

Molecules, 2021
Transient ischemia in brains causes neuronal damage, gliosis, and blood–brain barrier (BBB) breakdown, which is related to ischemia-induced brain dysfunction.
Tae-Kyeong Lee, Jae-Chul Lee, Jong-Dai Kim, Dae-Won Kim, Ji-Hyeon Ahn, Joon-Ha Park, Hyung-Il Kim, Jun-Hwi Cho, Soo-Young Choi, Moo-Ho Won, II-Jun Kang   +10 more
doaj   +1 more source

Brain tissue responses to ischemia [PDF]

Journal of Clinical Investigation, 2000
The brain is particularly vulnerable to ischemia. Complete interruption of blood flow to the brain for only 5 minutes triggers the death of vulnerable neurons in several brain regions, whereas 20–40 minutes of ischemia is required to kill cardiac myocytes or kidney cells.
J M, Lee, M C, Grabb, G J, Zipfel, D W, Choi   +3 more
openaire   +2 more sources

Pyrrolidine dithiocarbamate attenuates brain Aβ increase and improves long-term neurological outcome in rats after transient focal brain ischemia

Neurobiology of Disease, 2012
Evidence suggests an association between brain ischemia and Alzheimer's disease (AD) development. Amyloid plaques consisted of β-amyloid peptide (Aβ) in the brain are a pathological hallmark of AD. Little is known about how brain ischemia induces AD-like
Jiejie Li, Wenli Sheng, Chenzhuo Feng, Zhiyi Zuo   +3 more
doaj   +1 more source

Single-cell RNA sequencing unveils Lrg1's role in cerebral ischemia‒reperfusion injury by modulating various cells

Journal of Neuroinflammation, 2023
Background and purpose Cerebral ischemia‒reperfusion injury causes significant harm to human health and is a major contributor to stroke-related deaths worldwide. Current treatments are limited, and new, more effective prevention and treatment strategies
Zhaohui Ruan, Guosheng Cao, Yisong Qian, Longsheng Fu, Jinfang Hu, Tiantian Xu, Yaoqi Wu, Yanni Lv   +7 more
doaj   +1 more source

The role of glycogen synthase kinase 3 beta in brain injury induced by myocardial ischemia/reperfusion injury in a rat model of diabetes mellitus

Neural Regeneration Research, 2017
Myocardial ischemia/reperfusion injury can lead to severe brain injury. Glycogen synthase kinase 3 beta is known to be involved in myo-cardial ischemia/reperfusion injury and diabetes mellitus. However, the precise role of glycogen synthase kinase 3 beta
Bo Zhao, Wen-wei Gao, Ya-jing Liu, Meng Jiang, Lian Liu, Quan Yuan, Jia-bao Hou, Zhong-yuan Xia   +7 more
doaj   +1 more source

Protective Action of Indapamide, a Thiazide-Like Diuretic, on Ischemia-Induced Injury and Barrier Dysfunction in Mouse Brain Microvascular Endothelial Cells

Journal of Pharmacological Sciences, 2007
The aim of the present study was to elucidate the effects of indapamide on ischemic damage to the blood-brain barrier (BBB) in vitro. The ischemia /reperfusion conditions employed here significantly decreased the viability of mouse brain capillary ...
Tsuyoshi Nishioku, Fuyuko Takata, Atsushi Yamauchi, Noriko Sumi, Ikumi Yamamoto, Akiko Fujino, Mikihiko Naito, Takashi Tsuruo, Hideki Shuto, Yasufumi Kataoka   +9 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source