Results 41 to 50 of about 1,985,012 (310)

Paediatric traumatic Brain Injury: The relationship between Intracranial Pressure and Brain Oxygenation [PDF]

, 2009
Introduction: Intracranial pressure (ICP) monitoring is a cornerstone of care for patients with severe traumatic brain injury (TBI). The primary goal of ICP treatment is to preserve brain oxygenation, and since brain oxygenation is usually not measured ...
Rohlwink, Ursula Karin
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Pyrrolidine dithiocarbamate attenuates brain Aβ increase and improves long-term neurological outcome in rats after transient focal brain ischemia

Neurobiology of Disease, 2012
Evidence suggests an association between brain ischemia and Alzheimer's disease (AD) development. Amyloid plaques consisted of β-amyloid peptide (Aβ) in the brain are a pathological hallmark of AD. Little is known about how brain ischemia induces AD-like
Jiejie Li, Wenli Sheng, Chenzhuo Feng, Zhiyi Zuo   +3 more
doaj   +1 more source

Populus tomentiglandulosa Extract Is Rich in Polyphenols and Protects Neurons, Astrocytes, and the Blood-Brain Barrier in Gerbil Striatum Following Ischemia-Reperfusion Injury

Molecules, 2021
Transient ischemia in brains causes neuronal damage, gliosis, and blood–brain barrier (BBB) breakdown, which is related to ischemia-induced brain dysfunction.
Tae-Kyeong Lee, Jae-Chul Lee, Jong-Dai Kim, Dae-Won Kim, Ji-Hyeon Ahn, Joon-Ha Park, Hyung-Il Kim, Jun-Hwi Cho, Soo-Young Choi, Moo-Ho Won, II-Jun Kang   +10 more
doaj   +1 more source

Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration [PDF]

, 2010
Ischemic stroke is the second leading cause of death worldwide. Only one moderately effective therapy exists, albeit with contraindications that exclude 90% of the patients.
Shah, Ajay M., Sven G. Meuth, de Angelis, MH, Henrike Grund, Schmidt, HHHW, Grund, Henrike, Schuhmann, M.K., Hrabě de Angelis, M., Sabine Meurer, Schuhmann, Michael, Schrewe, A., Stoll, G., Peter Kraft, Martin Hrabé de Angelis, Barit, David, Barit, D., Schwarz, Tobias, de Angelis, Martin Hrabe, Stoll, Guido, Shah, AM, Klopstock, T., Weissmann, N, Schrewe, A, Mittal, M, Herrmann, A.M., Jones, Emma, Schmidt, Harald, Konstanze Barthel, Gailus-Durner, Valérie, Hrabé de Angelis, Martin, Kraft, Peter, Becker, L., Fuchs, H, Jandeleit-Dahm, Karin, Anja Schrewe, Harald H. H. W, Herrmann, AM, David Barit, Sven G Meuth, Meurer, S., Weissmann, Norbert, Schmidt, H.H., Michael K. Schuhmann, Kraft, P., Armitage, Melanie, Schuhmann, Michael K., Weissmann, N., Meuth, SG, Schwarz, T, Karin Jandeleit-Dahm, Barthel, Konstanze, Herrmann, Alexander M., Stoll, G, Meurer, Sabine, Schmidt, Harald H. H. W., Guido Stoll, Wingler, K., Christian Geis, Mittal, Manish, Lore Becker, Schrewe, Anja, Klopstock, Thomas, Fuchs, Helmut, Shah, A.M., Jandeleit-Dahm, K, Gailus-Durner, V, Barthel, K., Ajay M. Shah, Klopstock, T, Manish Mittal, Armitage, Melanie E., Meuth, S.G., Shah, Ajay, Norbert Weissmann, Harald H. H. W. Schmidt, Kraft, P, Michael K Schuhmann, Hrabe ́ De Angelis, Grund, H, Meuth, Sven, Meuth, Sven G., Jones, E., Thomas Klopstock, Geis, C, Schuhmann, MK, Tobias Schwarz, Grund, H., Kleinschnitz, Christoph, Melanie E Armitage, Barthel, K, Meurer, S, Kleinschnitz, C, Fuchs, H., Armitage, ME, Kleinschnitz, C., Kirstin Wingler, Valérie Gailus-Durner, Geis, Christian, Geis, C., Jones, E, Karin J, Gailus-Durner, V., Emma Jones, Becker, L, Jandeleit-Dahm, Karin A., Wingler, Kirstin, Helmut Fuchs, Mittal, M., Schwarz, T., Armitage, M.E., Er M. Herrmann, Jandeleit-Dahm, K., Harald H H W Schmidt, Becker, Lore, Ajay M Shah, de Angelis, Martin, Christoph Kleinschnitz, Herrmann, Alexander, Alexander M. Herrmann, Wingler, K, Alexander M Herrmann, Melanie E. Armitage, Barit, D, Kraft Peter, Mittal Manish, Klopstock Thomas, Meurer Sabine, Schwarz Tobias, Jones Emma, Schuhmann Michael K., Barit David, Barthel Konstanze, Geis Christian, Schmidt Harald H. H. W., de Angelis Martin Hrabé, Fuchs Helmut, Kleinschnitz Christoph, Armitage Melanie E., Kleinschnitz, C. ; Grund, H. ; Wingler, K. ; Armitage, M.E. ; Jones, E. ; Mittal, M. ; Barit, D. ; Schwarz, T. ; Geis, C. ; Kraft, P. ; Barthel, K. ; Schuhmann, M.K. ; Herrmann, A.M. ; Meuth, S.G. ; Stoll, G. ; Meurer, S. ; Schrewe, A. ; Becker, L. ; Gailus-Durner, V. ; Fuchs, H. ; Klopstock, T. ; Hrabé de Angelis, M. ; Jandeleit-Dahm, K. ; Shah, A.M. ; Weissmann, N. ; Schmidt, H.H., Wingler Kirstin, Stoll Guido, Weissmann Norbert, Schrewe Anja, Jandeleit-Dahm Karin, Meuth Sven G., Shah Ajay M., Herrmann Alexander M., Grund Henrike, Gailus-Durner Valérie, Becker Lore   +149 more
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Single-cell RNA sequencing unveils Lrg1's role in cerebral ischemia‒reperfusion injury by modulating various cells

Journal of Neuroinflammation, 2023
Background and purpose Cerebral ischemia‒reperfusion injury causes significant harm to human health and is a major contributor to stroke-related deaths worldwide. Current treatments are limited, and new, more effective prevention and treatment strategies
Zhaohui Ruan, Guosheng Cao, Yisong Qian, Longsheng Fu, Jinfang Hu, Tiantian Xu, Yaoqi Wu, Yanni Lv   +7 more
doaj   +1 more source

Involvement of Nitric Oxide in Microcirculatory Reactions after Ischemia-Reperfusion of the Rat Urinary Bladder [PDF]

, 2009
Background: Nitric oxide ( NO) plays a role in inflammation. Our aim was to investigate the role of NO in the microcirculatory changes after ischemia-reperfusion (I/R) of the bladder using intravital videomicroscopy (IVM).
Bajory, Z., Pajor László, Kiraly, I., Szabó Andrea, Messmer Konrad, Király István, Pajor, L., Bajory Zoltán, Messmer, K., Szabo, A.   +9 more
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The role of glycogen synthase kinase 3 beta in brain injury induced by myocardial ischemia/reperfusion injury in a rat model of diabetes mellitus

Neural Regeneration Research, 2017
Myocardial ischemia/reperfusion injury can lead to severe brain injury. Glycogen synthase kinase 3 beta is known to be involved in myo-cardial ischemia/reperfusion injury and diabetes mellitus. However, the precise role of glycogen synthase kinase 3 beta
Bo Zhao, Wen-wei Gao, Ya-jing Liu, Meng Jiang, Lian Liu, Quan Yuan, Jia-bao Hou, Zhong-yuan Xia   +7 more
doaj   +1 more source

Brain tissue responses to ischemia [PDF]

Journal of Clinical Investigation, 2000
The brain is particularly vulnerable to ischemia. Complete interruption of blood flow to the brain for only 5 minutes triggers the death of vulnerable neurons in several brain regions, whereas 20–40 minutes of ischemia is required to kill cardiac myocytes or kidney cells.
J M, Lee, M C, Grabb, G J, Zipfel, D W, Choi   +3 more
openaire   +2 more sources

Protective Action of Indapamide, a Thiazide-Like Diuretic, on Ischemia-Induced Injury and Barrier Dysfunction in Mouse Brain Microvascular Endothelial Cells

Journal of Pharmacological Sciences, 2007
The aim of the present study was to elucidate the effects of indapamide on ischemic damage to the blood-brain barrier (BBB) in vitro. The ischemia /reperfusion conditions employed here significantly decreased the viability of mouse brain capillary ...
Tsuyoshi Nishioku, Fuyuko Takata, Atsushi Yamauchi, Noriko Sumi, Ikumi Yamamoto, Akiko Fujino, Mikihiko Naito, Takashi Tsuruo, Hideki Shuto, Yasufumi Kataoka   +9 more
doaj   +1 more source

Attenuation of Focal Cerebral Ischemic Injury Following Post Ischemic Inhibition of Angiotensin Converting Enzyme (ACE) Activity in Normotensive Rat [PDF]

Central renin angiotensin system has an important role on the cerebral microcirculation and metabolism. Our previous work showed that inhibition of angiotensin converting enzyme (ACE) activity prior to induction of ischemia protected the brain from ...
دهقان, غلامعباس, پناهپور, حمداله   +1 more
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