Results 41 to 50 of about 2,097,140 (305)

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Comparing the Effect of Semi‐Immersive Virtual Reality, Computerized Cognitive Training, and Traditional Rehabilitation on Cognitive Function in Multiple Sclerosis: A Randomized Clinical Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio, Desiree Latella, Lilla Bonanno, Paulo Cezar Rocha dos Santos, Marcos Maldonado‐Díaz, Meir Plotnik, Rosaria De Luca, Angelo Quartarone, Rocco Salvatore Calabrò   +8 more
wiley   +1 more source

Isoflurane postconditioning reduces ischemia-induced nuclear factor-κB activation and interleukin 1β production to provide neuroprotection in rats and mice

Neurobiology of Disease, 2013
Application of isoflurane, a volatile anesthetic, after brain ischemia can reduce ischemic brain injury in rodents (isoflurane postconditioning). This study is designed to determine whether isoflurane postconditioning improves long-term neurological ...
Hong Li, Jinbo Yin, Liaoliao Li, Jiao Deng, Chenzhuo Feng, Zhiyi Zuo   +5 more
doaj   +1 more source

Cognitive function restoration in rats with chronic brain ischemia using Semax and hopantenic acid comprehensive administration

Journal of Education, Health and Sport, 2023
The relevance and importance of treating patients with ischemic brain lesions are indisputable. Chronic ischemic processes in the brain occur much more frequently than acute cerebral circulation disorders, leading to prolonged disability and being the ...
V. Kirchev
doaj   +1 more source

The role of endotoxin, the TNF family of cytokines and intracellular pH in perinatal hypoxic-ischemic brain injury [PDF]

, 2010
To explore the effect of endotoxin as a sensitising agent prior to neonatal hypoxiaischemia differing doses of endotoxin (E. coli lipopolysaccharide, LPS) were given to neonatal mice prior to hypoxia-ischemia, with sensitising effects noted at dosages ...
Kendall, G.
core  

[18F]DPA-714: Direct Comparison with [11C]PK11195 in a Model of Cerebral Ischemia in Rats [PDF]

, 2013
Purpose: Neuroinflammation is involved in several brain disorders and can be monitored through expression of the translocator protein 18 kDa (TSPO) on activated microglia.
Banister, S D, Julyan, P, Rothwell, N J, Alison Smigova (281869), Galea, James, Cawthorne, Christopher, Wilkinson, S M, Christian Prenant (281864), Herholz, K; id_orcid, Renaud Maroy (281866), Herholz, Karl, Michael Kassiou, Wilkinson, Shane M, Peter Julyan (281871), Maroy, Renaud, Gavin Brown, Samuel D Banister, Boutin, Hervé, Banister, Samuel D, Greenhalgh, A D, Wilkinson, Shane M., Karl Herholz, Prenant, Christian, Karl Herholz (281875), Boutin, H, Hervé Boutin (281863), Michael Kassiou (281876), Hervé Boutin, Christopher Cawthorne, Rothwell, Nancy J., Brown, G, Nancy J. Rothwell (281877), Banister, Samuel D., Kassiou, M, James Galea (281867), Alison Smigova, Julyan, Peter, Brown, Gavin, Smigova, Alison, Smigova, A, Andrew D. Greenhalgh (281868), Gavin Brown (281874), James Galea, Kassiou, Michael, Rothwell, Nancy J, Christian Prenant, Samuel D. Banister (281873), Christopher Cawthorne (281870), Renaud Maroy, Maroy, R, Peter Julyan, Prenant, C, Greenhalgh, Andrew D., Greenhalgh, Andrew D, Shane M. Wilkinson (281872), Boutin, Hervé; id_orcid, Andrew D Greenhalgh, Cawthorne, C, Nancy J Rothwell, Galea, J, Shane M Wilkinson, Wilkinson Shane M., Rothwell, N, Banister Samuel D., Maroy Renaud, Greenhalgh, A, Banister, S, Prenant Christian, Herholz, K, Greenhalgh Andrew D., Herholz Karl, Julyan Peter, Julyan, Peter J, Galea James, Boutin Hervé, Smigova Alison, Wilkinson, S, Brown Gavin, Cawthorne Christopher, Kassiou Michael, Rothwell Nancy J.   +80 more
core   +1 more source

Acute Kidney Injury After Mechanical Thrombectomy for Stroke in Patients With Pre‐Existing Renal Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk, Marcel Pilarek, Emilia Jaworska, Natalia Kardas, Oliwia Barnaś, Julia Woźniak, Iga Machała, Julia Węgrzynek‐Gallina, Joanna Siuda, Anna Hawrot‐Kawecka, Anetta Lasek‐Bal   +10 more
wiley   +1 more source

MicroRNA responses to focal cerebral ischemia in male and female mouse brain

Frontiers in Molecular Neuroscience, 2014
Stroke occurs with greater frequency in men than in women across diverse ethnic backgrounds and nationalities. Work from our lab and others have revealed a sex-specific sensitivity to cerebral ischemia whereby males exhibit a larger extent of brain ...
Theresa Ann Lusardi, Stephanie Jane Murphy, Jay Ian Phillips, Yingxin eChen, Catherine Monica Davis, Jennifer Marie Young, Simon John Thompson, Julie Anne Saugstad   +7 more
doaj   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng, Diego Z. Carvalho, Shahid Karim, Anwar Chahal, Virend K. Somers   +4 more
wiley   +1 more source

Hypothermia selectively protects the anterior forebrain mesocircuit during global cerebral ischemia

Neural Regeneration Research, 2022
Hypothermia is an important protective strategy against global cerebral ischemia following cardiac arrest. However, the mechanisms of hypothermia underlying the changes in different regions and connections of the brain have not been fully elucidated ...
Xiao-Hua Wang, Wei Jiang, Si-Yuan Zhang, Bin-Bin Nie, Yi Zheng, Feng Yan, Jian-Feng Lei, Tian-Long Wang   +7 more
doaj   +1 more source