Results 31 to 40 of about 823,827 (207)
Potassium channel activators protect the N-methyl-D-aspartate-induced cerebral vascular dilation after combined hypoxia and ischemia in piglets [PDF]
, 1998 Background and Purpose-Cerebral arteriolar dilation to N-methyl-D-aspartate (NMDA) is a neuronally mediated multistep process that is sensitive to cerebral hypoxia and ischemia (H/I).
Domoki, Ferenc +2 more
core +1 more source
Early changes in transient adenosine during cerebral ischemia and reperfusion injury. [PDF]
PLoS ONE, 2018 Adenosine is an important neuromodulator in the central nervous system, and tissue adenosine levels increase during ischemic events, attenuating excitotoxic neuronal injury.
Mallikarjunarao Ganesana, B Jill Venton
doaj +1 more source
microRNA-455-5p alleviates neuroinflammation in cerebral ischemia/reperfusion injury
Neural Regeneration Research, 2022 Neuroinflammation is a major pathophysiological factor that results in the development of brain injury after cerebral ischemia/reperfusion. Downregulation of microRNA (miR)-455-5p after ischemic stroke has been considered a potential biomarker and ...
Jian-Song Zhang +10 more
doaj +1 more source
Neural Regeneration Research, 2017 Ischemic preconditioning elicited by a non-fatal brief occlusion of blood flow has been applied for an experimental therapeutic strategy against a subsequent fatal ischemic insult.
In Hye Kim +12 more
doaj +1 more source
Pathophysiology of Cerebral Ischemia
Neurologia medico-chirurgica, 1998 The purpose of this manuscript is to briefly review the pathophysiology of cerebral ischemia. Ischemic thresholds are well-defined in lower animals. The concept of the ischemic penumbra may include regions of brain around deeper regions of ischemia but has also been defined in terms of brain salvageable by reperfusion or by pharmacological therapies ...
MACDONALD, R. Loch, STOODLEY, Marcus
openaire +2 more sources
A depletable pool of adenosine in area CA1 of the rat hippocampus [PDF]
, 2001 Adenosine plays a major modulatory and neuroprotective role in the mammalian CNS. During cerebral metabolic stress, such as hypoxia or ischemia, the increase in extracellular adenosine inhibits excitatory synaptic transmission onto vulnerable neurons via
Darren Caldwell +9 more
core +1 more source
Epigenetic Mechanisms in Cerebral Ischemia [PDF]
Journal of Cerebral Blood Flow & Metabolism, 2013 Treatment efficacy for ischemic stroke represents a major challenge. Despite fundamental advances in the understanding of stroke etiology, therapeutic options to improve functional recovery remain limited. However, growing knowledge in the field of epigenetics has dramatically changed our understanding of gene regulation in the last few decades ...
Schweizer, Sophie +2 more
openaire +2 more sources
[18F]DPA-714: Direct Comparison with [11C]PK11195 in a Model of Cerebral Ischemia in Rats [PDF]
, 2013 Purpose: Neuroinflammation is involved in several brain disorders and can be monitored through expression of the translocator protein 18 kDa (TSPO) on activated microglia.
Banister, S D +80 more
core +1 more source
Cav3.2 channel regulates cerebral ischemia/reperfusion injury: a promising target for intervention
Neural Regeneration ResearchCalcium influx into neurons triggers neuronal death during cerebral ischemia/reperfusion injury. Various calcium channels are involved in cerebral ischemia/reperfusion injury. Cav3.2 channel is a main subtype of T-type calcium channels.
Feibiao Dai +9 more
doaj +1 more source
MicroRNA-670 aggravates cerebral ischemia/reperfusion injury via the Yap pathway
Neural Regeneration Research, 2021 Apoptosis is an important programmed cell death process involved in ischemia/reperfusion injury. MicroRNAs are considered to play an important role in the molecular mechanism underlying the regulation of cerebral ischemia and reperfusion injury. However,
Shi-Jia Yu +4 more
doaj +1 more source